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J. Gattuso, M. Glasby, S. Gschmeissner, R. Norris (1989)
A comparison of immediate and delayed repair of peripheral nerves using freeze-thawed autologous skeletal muscle grafts--in the rat.British journal of plastic surgery, 42 3
Bain, S. Mackinnon, D. Hunter (1989)
Functional Evaluation of Complete Sciatic, Peroneal, and Posterior Tibial Nerve Lesions in the RatPlastic and Reconstructive Surgery, 83
SM Ojagh, MA Rezaei, SH Razavi, SMH Hosseini (2010)
Development and evaluation of a novel biodegradable film made from chitosan and cinnamon essential oil with low affinity toward waterFood Chem, 122
M. Bervar (2000)
Video analysis of standing — an alternative footprint analysis to assess functional loss following injury to the rat sciatic nerveJournal of Neuroscience Methods, 102
C. Grothe, K. Heese, C. Meisinger, K. Wewetzer, D. Kunz, P. Cattini, U. Otten (2000)
Expression of interleukin-6 and its receptor in the sciatic nerve and cultured Schwann cells: relation to 18-kD fibroblast growth factor-2Brain Research, 885
D. Smith (2013)
FDA approved guidance conduits and wraps for peripheral nerve injury: A review of materials and efficacyYearbook of Plastic and Aesthetic Surgery, 2013
J. Aitken (1949)
The effect of peripheral connexions on the maturation of regenerating nerve fibres.Journal of anatomy, 83 Pt 1
Gan Wang, G. Lu, Q. Ao, Y. Gong, Xiufang Zhang (2009)
Preparation of cross-linked carboxymethyl chitosan for repairing sciatic nerve injury in ratsBiotechnology Letters, 32
J. Fraher, P. Dockery (1998)
A strong myelin thickness‐axon size correlation emerges in developing nerves despite independent growth of both parametersJournal of Anatomy, 193
C. Grothe, G. Nikkhah (2001)
The role of basic fibroblast growth factor in peripheral nerve regenerationAnatomy and Embryology, 204
R. Quarles (2002)
Myelin sheaths: glycoproteins involved in their formation, maintenance and degenerationCellular and Molecular Life Sciences CMLS, 59
R. Tanzer (1971)
Sensory-nerve-conduction velocity and two-point discrimination in sutured nervesPlastic and Reconstructive Surgery, 47
M. Rosales-Cortés, J. Peregrina-Sandoval, J. Bañuelos-Pineda, R. Sarabia-Estrada, C. Gómez-Rodiles, E. Albarrán-Rodríguez, G. Zaitseva, M. Pita-López (2003)
Immunological Study of a Chitosan Prosthesis in the Sciatic Nerve Regeneration of the Axotomized DogJournal of Biomaterials Applications, 18
M. Sendtner, K. Stöckli, H. Thoenen (1992)
Synthesis and localization of ciliary neurotrophic factor in the sciatic nerve of the adult rat after lesion and during regenerationThe Journal of Cell Biology, 118
Kazuya Matsumoto, Katsunori Ohnishi, T. Kiyotani, T. Sekine, H. Ueda, Tatsuo Nakamura, K. Endo, Y. Shimizu (2000)
Peripheral nerve regeneration across an 80-mm gap bridged by a polyglycolic acid (PGA)–collagen tube filled with laminin-coated collagen fibers: a histological and electrophysiological evaluation of regenerated nervesBrain Research, 868
P. Dinh, A. Hazel, Winnie Palispis, Sourabh Suryadevara, Ranjan Gupta (2009)
Functional assessment after sciatic nerve injury in a rat modelMicrosurgery, 29
A. Varejão, P. Melo-Pinto, M. Meek, V. Filipe, J. Bulas-Cruz (2004)
Methods for the experimental functional assessment of rat sciatic nerve regenerationNeurological Research, 26
A. Dellon, S. Mackinnon (1989)
Sciatic nerve regeneration in the rat. Validity of walking track assessment in the presence of chronic contracturesMicrosurgery, 10
Aijun Wang, Q. Ao, Yujun Wei, K. Gong, Xuesong Liu, N. Zhao, Y. Gong, Xiufang Zhang (2007)
Physical properties and biocompatibility of a porous chitosan-based fiber-reinforced conduit for nerve regenerationBiotechnology Letters, 29
E Almquist, O Eeg-Olofsson (1970)
Sensory-nerve-conduction velocity and two-point discrimination in sutured nervesJ Bone Joint Surg Am, 52
M. Rezaei, S. Ojagh, S. Razavi, S. Hosseini (2010)
Development and evaluation of a novel biodegradable film made from chitosan and cinnamon essential oil with low affinity toward waterJournal of Biotechnology, 150
Yi-lo Lin, J. Jen, S. Hsu, I. Chiu (2008)
Sciatic nerve repair by microgrooved nerve conduits made of chitosan-gold nanocomposites.Surgical neurology, 70 Suppl 1
G. Benedetto, G. Zura, R. Mazzucchelli, A. Santinelli, M. Scarpelli, A. Bertani (1998)
Nerve regeneration through a combined autologous conduit (vein plus acellular muscle grafts).Biomaterials, 19 1-3
W. Dunnen, I. Stokroos, E. Blaauw, A. Holwerda, Aj Pennings, P. Robinson, J. Schakenraad (1996)
Light-microscopic and electron-microscopic evaluation of short-term nerve regeneration using a biodegradable poly(DL-lactide-epsilon-caprolacton) nerve guide.Journal of biomedical materials research, 31 1
George Yancopoulos, P. Maisonpierre, Nancy Ip, T. Aldrich, Leonardo Belluscio, T. Boulton, Melanie Cobb, Stephen Squinto, Mark Furth (1990)
Neurotrophic factors, their receptors, and the signal transduction pathways they activate.Cold Spring Harbor symposia on quantitative biology, 55
S. Mackinnon, A. Hudson, D. Hunter (1985)
Histologic Assessment of Nerve Regeneration in the RatPlastic and Reconstructive Surgery, 75
K. Tucker, M. Meyer, Y. Barde (2001)
Neurotrophins are required for nerve growth during developmentNature Neuroscience, 4
G. Evans (2001)
Peripheral nerve injury: A review and approach to tissue engineered constructsThe Anatomical Record, 263
M. Meek, J. Coert (2008)
US Food and Drug Administration/Conformit Europe-Approved Absorbable Nerve Conduits for Clinical Repair of Peripheral and Cranial NervesAnnals of Plastic Surgery, 60
R. Gadient, U. Otten (1996)
Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory gangliaBrain Research, 724
By Aitken, M. Sharman, J. Young (1947)
Maturation of regenerating nerve fibres with various peripheral connexions.Journal of anatomy, 81 Pt 1
E. Almquist, O. Eeg‐Olofsson (1970)
Family violence: tools for the orthopaedic surgeon.Journal of Bone and Joint Surgery, American Volume, 52
Hisham Fansa, T. Dodic, Gerald Wolf, W. Schneider, G. Keilhoff (2003)
Tissue engineering of peripheral nerves: Epineurial grafts with application of cultured Schwann cellsMicrosurgery, 23
A. Höke, Chu Cheng, D. Zochodne (2000)
Expression of glial cell line‐derived neurotrophic factor family of growth factors in peripheral nerve injury in ratsNeuroReport, 11
Ninjiang Shen, Jia-kai Zhu (1995)
Application of sciatic functional index in nerve functional assessmentMicrosurgery, 16
M. Zimmermann (1983)
Ethical guidelines for investigations of experimental pain in conscious animalsPain, 16
F. Kanaya, J. Firrell, W. Breidenbach (1996)
Sciatic Function Index, Nerve Conduction Tests, Muscle Contraction, and Axon Morphometry as Indicators of RegenerationPlastic and Reconstructive Surgery, 98
W. Ngeow (2010)
Scar less: a review of methods of scar reduction at sites of peripheral nerve repair.Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 109 3
F. Castañeda, R. Kinne (2002)
Omental graft improves functional recovery of transected peripheral nerveMuscle & Nerve, 26
D. Basso, M. Beattie, J. Bresnahan (1995)
A sensitive and reliable locomotor rating scale for open field testing in rats.Journal of neurotrauma, 12 1
J. Boyd, T. Gordon (2003)
Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injuryMolecular Neurobiology, 27
Xiaoxia Li, Wei Wang, Guoqiang Wei, Guanxiong Wang, Wei-guo Zhang, Xiao-jun Ma (2010)
Immunophilin FK506 loaded in chitosan guide promotes peripheral nerve regenerationBiotechnology Letters, 32
W. Ngeow (2010)
ERRATUM to “Scar less: a review of methods of scar reduction at sites of peripheral nerve repair” [Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010;109:357-66]Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 110
S. Korsching (1993)
The neurotrophic factor concept: a reexamination, 13
L. Medinaceli, W. Freed, R. Wyatt (1982)
An index of the functional condition of rat sciatic nerve based on measurements made from walking tracksExperimental Neurology, 77
Chun-Jung Chen, Y. Ou, Su-Lan Liao, Wen-Ying Chen, Shih-Yun Chen, Ching-Wen Wu, Chun-Chiang Wang, Wen-yi Wang, Yong-San Huang, S. Hsu (2007)
Transplantation of bone marrow stromal cells for peripheral nerve repairExperimental Neurology, 204
S. Geuna, D. Gigo‐Benato, A. Rodrigues (2004)
On sampling and sampling errors in histomorphometry of peripheral nerve fibersMicrosurgery, 24
Nooshin Ghayemi, A. Haghighat, K. Amini, R. Mohammadi (2014)
Functional effect of local administration of glial derived neurotrophic factor combined with inside-out artery graft on sciatic nerve regeneration in rat.International journal of surgery, 12 5
P. Robinson, A. Loescher, Keith Smith (2000)
A prospective, quantitative study on the clinical outcome of lingual nerve repair.The British journal of oral & maxillofacial surgery, 38 4
Technological advances in diagnostic imaging, neurosurgical instrumentation, and the use of a surgical microscope have resulted in pronounced improvements in the diagnosis and repair of transected peripheral nerves. Effect of local fibroblast growth factor (FGF) on nerve regeneration was assessed. Eighty male Wistar rats were divided into four experimental groups (n = 20), randomly: In transected group, left sciatic nerve was transected and stumps were fixed in adjacent muscle. In treatment group, defect was bridged using a chitosan conduit filled with 10 μL FGF. In chitosan conduit (CHIT) group, the conduit was filled with phosphate-buffered saline. In normal control group, sciatic nerve was exposed and manipulated. Each group was subdivided into four subgroups of five animals each and nerve fibers were studied in a 12-week period. Behavioral, functional, electrophysiological, and gastrocnemius muscle mass findings and morphometric indices confirmed faster recovery of regenerated axons in CHIT/FGF than in CHIT group (p < 0.05). Immunohistochemical reactions to S-100 in CHIT/FGF were more positive than that in CHIT group. FGF improved functional recovery and morphometric indices of sciatic nerve. It could be considered as an effective treatment for peripheral nerve repair in practice.
Comparative Clinical Pathology – Springer Journals
Published: Aug 7, 2014
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