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Effect of glyprolines PGP and N-acetyl-PGP on the expression of cytokine genes during stress- and acetate-induced ulceration

Effect of glyprolines PGP and N-acetyl-PGP on the expression of cytokine genes during stress- and... We have studied the effects of glyprolines PGP and N-acetyl-PGP on cytokine gene expression during stress and acetate-induced ulceration. Levels of RNA in mononuclear cells in circulating blood were evaluated using reverse transcription polymerase chain reaction. Intranasal administration of PGP (3.7 μmol/kg) has had a significant protective effect against stress-induced (59.4%) and acetate-induced (78.5%) ulceration in rats. N-acetyl-PGP has not changed the area of stress-induced damage, but it tended to inhibit the development of acetate ulcers. We found that stress-induced damage of gastric mucosa is accompanied by an increase in TNFα transcription and a decrease in IL-4 transcription. The development of acetate ulcers is accompanied by a decrease in expression of a number of cytokines: IFNα, IFNγ, IL-2, IL-4, IL-6, IL-12, and TNFα. The protective effect of PGP is accompanied by an increase in expression of IL-6. When N-acetyl-PGP is administered, an increase in the expression of Th-1 and Th-2 cytokines have been observed: IFNα, IFNγ, and IL-4. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Moscow University Biological Sciences Bulletin Springer Journals

Effect of glyprolines PGP and N-acetyl-PGP on the expression of cytokine genes during stress- and acetate-induced ulceration

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References (17)

Publisher
Springer Journals
Copyright
Copyright © 2014 by Allerton Press, Inc.
Subject
Life Sciences; Biochemistry, general; Cell Biology; Life Sciences, general; Plant Sciences; Zoology
ISSN
0096-3925
eISSN
1934-791X
DOI
10.3103/S0096392514040105
Publisher site
See Article on Publisher Site

Abstract

We have studied the effects of glyprolines PGP and N-acetyl-PGP on cytokine gene expression during stress and acetate-induced ulceration. Levels of RNA in mononuclear cells in circulating blood were evaluated using reverse transcription polymerase chain reaction. Intranasal administration of PGP (3.7 μmol/kg) has had a significant protective effect against stress-induced (59.4%) and acetate-induced (78.5%) ulceration in rats. N-acetyl-PGP has not changed the area of stress-induced damage, but it tended to inhibit the development of acetate ulcers. We found that stress-induced damage of gastric mucosa is accompanied by an increase in TNFα transcription and a decrease in IL-4 transcription. The development of acetate ulcers is accompanied by a decrease in expression of a number of cytokines: IFNα, IFNγ, IL-2, IL-4, IL-6, IL-12, and TNFα. The protective effect of PGP is accompanied by an increase in expression of IL-6. When N-acetyl-PGP is administered, an increase in the expression of Th-1 and Th-2 cytokines have been observed: IFNα, IFNγ, and IL-4.

Journal

Moscow University Biological Sciences Bulletin – Springer Journals

Published: Jan 4, 2015

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