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Effect of Cyclooxygenase Inhibitors Etoricoxib and Diclofenac Sodium and Their Combinations with Mexidol on Blood Pressure and Hematological Indices in Rats

Effect of Cyclooxygenase Inhibitors Etoricoxib and Diclofenac Sodium and Their Combinations with... —The effect on blood pressure (BP), hematological indices, and body weight of rats was evaluated for nonselective cyclooxygenase (COX) inhibitor diclofenac sodium (1 and 5 mg/kg) and selective COX-2 inhibitor etoricoxib (1 and 10 mg/kg), 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol, 25 mg/kg) and combinations of these nonsteroidal anti-inflammatory drugs (NSAIDs, 1 mg/kg) with mexidol administered per os as a 2- and 3-week daily course. BP increase was observed in rats after 3 weeks of NSAID administration. Specifically, etoricoxib at both doses increased the systolic and diastolic pressures, while diclofenac sodium at a dose of 5 mg/kg only affected the diastolic pressure. Mexidol prevented the BP increase when taken together with etoricoxib. The administration of NSAIDs at maximum doses for 2 weeks was associated with an increase in certain leukocyte type counts. Furthermore, diclofenac sodium increased the number of platelets and induced iron-deficiency anemia, indicating the NSAID-induced enteropathy. Both NSAIDs were shown to negatively affect the dynamics of weight gain in rats, with diclofenac sodium having a more pronounced effect. The combination of diclofenac sodium and etoricoxib with mexidol did not enhance the negative effects of NSAIDs on hematological parameters and weight gain in rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Moscow University Biological Sciences Bulletin Springer Journals

Effect of Cyclooxygenase Inhibitors Etoricoxib and Diclofenac Sodium and Their Combinations with Mexidol on Blood Pressure and Hematological Indices in Rats

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References (20)

Publisher
Springer Journals
Copyright
Copyright © Allerton Press, Inc. 2022. ISSN 0096-3925, Moscow University Biological Sciences Bulletin, 2022, Vol. 77, No. 1, pp. 18–24. © Allerton Press, Inc., 2022. Russian Text © The Author(s), 2022, published in Vestnik Moskovskogo Universiteta, Seriya 16: Biologiya, 2022, Vol. 77, No. 1, pp. 22–28.
ISSN
0096-3925
eISSN
1934-791X
DOI
10.3103/s0096392522010059
Publisher site
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Abstract

—The effect on blood pressure (BP), hematological indices, and body weight of rats was evaluated for nonselective cyclooxygenase (COX) inhibitor diclofenac sodium (1 and 5 mg/kg) and selective COX-2 inhibitor etoricoxib (1 and 10 mg/kg), 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol, 25 mg/kg) and combinations of these nonsteroidal anti-inflammatory drugs (NSAIDs, 1 mg/kg) with mexidol administered per os as a 2- and 3-week daily course. BP increase was observed in rats after 3 weeks of NSAID administration. Specifically, etoricoxib at both doses increased the systolic and diastolic pressures, while diclofenac sodium at a dose of 5 mg/kg only affected the diastolic pressure. Mexidol prevented the BP increase when taken together with etoricoxib. The administration of NSAIDs at maximum doses for 2 weeks was associated with an increase in certain leukocyte type counts. Furthermore, diclofenac sodium increased the number of platelets and induced iron-deficiency anemia, indicating the NSAID-induced enteropathy. Both NSAIDs were shown to negatively affect the dynamics of weight gain in rats, with diclofenac sodium having a more pronounced effect. The combination of diclofenac sodium and etoricoxib with mexidol did not enhance the negative effects of NSAIDs on hematological parameters and weight gain in rats.

Journal

Moscow University Biological Sciences Bulletin – Springer Journals

Published: Mar 1, 2022

Keywords: diclofenac sodium; etoricoxib; mexidol; blood pressure; hematological indices; rats

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