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Effect of CMC Concentration on Cell Growth Behavior of PVA/CMC Hydrogel

Effect of CMC Concentration on Cell Growth Behavior of PVA/CMC Hydrogel Polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC) hydrogels containing various CMC concentration of 2 to 10 wt% are prepared using cyclic freezing/thawing and subsequent γ-ray irradiation to evaluate the effect of CMC content on cell growth rate of the hydrogels. A 3-D porous network structure is successfully formed via physical and chemical crosslinking. The pore size and the metronidazole drug release rate of the PVA/CMC hydrogels increase with raising the CMC concentration from 2 to 10 wt%, however, the structural integrity is severely damaged. The highest compressive strength of 99.2 ± 9.6 kPa and the fastest cell growth determined by scratch assay and enzyme-linked immunosorbent assay are observed for the irradiated PVA/6 wt% CMC hydrogels, indicating that they are highly suitable for wound dressing requiring fast regeneration.[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "Macromolecular Research" Springer Journals

Effect of CMC Concentration on Cell Growth Behavior of PVA/CMC Hydrogel

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References (26)

Publisher
Springer Journals
Copyright
Copyright © The Polymer Society of Korea and Springer 2020
ISSN
1598-5032
eISSN
2092-7673
DOI
10.1007/s13233-020-8106-0
Publisher site
See Article on Publisher Site

Abstract

Polyvinyl alcohol (PVA)/carboxymethyl cellulose (CMC) hydrogels containing various CMC concentration of 2 to 10 wt% are prepared using cyclic freezing/thawing and subsequent γ-ray irradiation to evaluate the effect of CMC content on cell growth rate of the hydrogels. A 3-D porous network structure is successfully formed via physical and chemical crosslinking. The pore size and the metronidazole drug release rate of the PVA/CMC hydrogels increase with raising the CMC concentration from 2 to 10 wt%, however, the structural integrity is severely damaged. The highest compressive strength of 99.2 ± 9.6 kPa and the fastest cell growth determined by scratch assay and enzyme-linked immunosorbent assay are observed for the irradiated PVA/6 wt% CMC hydrogels, indicating that they are highly suitable for wound dressing requiring fast regeneration.[graphic not available: see fulltext]

Journal

"Macromolecular Research" – Springer Journals

Published: Aug 7, 2020

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