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Cardiol Ther (2015) 4:1–3 DOI 10.1007/s40119-015-0038-y EDITORIAL • • Robert P. Giugliano Uwe Zeymer Ian Menown To view enhanced content go to www.cardiologytherapy-open.com Received: January 27, 2015 / Published online: March 13, 2015 The Author(s) 2015. This article is published with open access at Springerlink.com Keywords: PCSK9 inhibitor; Low-density In the field of lipids, several studies with lipoprotein cholesterol; Ezetimibe; Statin proprotein convertase subtilisin kexin 9 therapy; Angiotensin receptor blocker; (PCSK9) inhibitors demonstrated their potent LCZ696; Valsartan/sacubitril; Enalapril; effects to lower low-density-lipoprotein Transcatheter aortic valve implantation; cholesterol (LDL-C) in a wide variety of Antiplatelet therapy patients. In addition to reducing LDL-C by 50% or more, PCSK9 inhibitors have favorable effects on apolipoprotein-B, lipoprotein (a), and The year 2014 brought a large number of triglycerides. Although much less potent than important advances to cardiovascular medicine the PCSK9 inhibitors, the cholesterol that are likely to impact the field for many absorption inhibitor ezetimibe became the first years, if not decades [1]. Herein are our non-statin to demonstrate a reduction in thoughts on the top stories in 2014 and what cardiovascular events on top of background is likely to remain hot in 2015. statin therapy. In the IMPROVE IT trial (ClinicalTrials.gov NCT
Cardiology and Therapy – Springer Journals
Published: Mar 13, 2015
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