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Dysregulation of Group 3 Innate Lymphoid Cells in the Pathogenesis of Inflammatory Bowel Disease

Dysregulation of Group 3 Innate Lymphoid Cells in the Pathogenesis of Inflammatory Bowel Disease Curr Allergy Asthma Rep (2016) 16: 73 DOI 10.1007/s11882-016-0652-3 IMMUNE DEFICIENCY AND DYSREGULATION (DP HUSTON AND C KUO, SECTION EDITORS) Dysregulation of Group 3 Innate Lymphoid Cells in the Pathogenesis of Inflammatory Bowel Disease 1 1 Marianne Forkel & Jenny Mjösberg Published online: 19 September 2016 The Author(s) 2016. This article is published with open access at Springerlink.com . . Abstract Keywords Innate lymphoid cells ILC3 Inflammatory Purpose of Review Here, we review recent literature indicat- bowel disease Intestinal homeostasis ing a role of innate lymphoid cells in human inflammatory bowel disease with a focus on the plastic population of ILC3. Recent Findings Many studies suggest an involvement of Introduction ILC3 in human intestinal inflammation. ILC3 present the most abundant ILC subtype in the human intestine at steady Inflammatory bowel disease (IBD) is an increasing medical state. In IBD, this composition is skewed towards ILCs show- problem with a strongly impaired quality of life for the pa- ing anILC1phenotype and cytokineprofile.Thischangeis tients. Until today, the causes and molecular mechanism of the likely due to the microenvironment causing skewing of the disease are not clear and the available treatment regimens are functionally plastic ILC subsets. Interactions between ILCs unsatisfying. A http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Allergy and Asthma Reports Springer Journals

Dysregulation of Group 3 Innate Lymphoid Cells in the Pathogenesis of Inflammatory Bowel Disease

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References (84)

Publisher
Springer Journals
Copyright
Copyright © 2016 by The Author(s)
Subject
Medicine & Public Health; Allergology
ISSN
1529-7322
eISSN
1534-6315
DOI
10.1007/s11882-016-0652-3
pmid
27645534
Publisher site
See Article on Publisher Site

Abstract

Curr Allergy Asthma Rep (2016) 16: 73 DOI 10.1007/s11882-016-0652-3 IMMUNE DEFICIENCY AND DYSREGULATION (DP HUSTON AND C KUO, SECTION EDITORS) Dysregulation of Group 3 Innate Lymphoid Cells in the Pathogenesis of Inflammatory Bowel Disease 1 1 Marianne Forkel & Jenny Mjösberg Published online: 19 September 2016 The Author(s) 2016. This article is published with open access at Springerlink.com . . Abstract Keywords Innate lymphoid cells ILC3 Inflammatory Purpose of Review Here, we review recent literature indicat- bowel disease Intestinal homeostasis ing a role of innate lymphoid cells in human inflammatory bowel disease with a focus on the plastic population of ILC3. Recent Findings Many studies suggest an involvement of Introduction ILC3 in human intestinal inflammation. ILC3 present the most abundant ILC subtype in the human intestine at steady Inflammatory bowel disease (IBD) is an increasing medical state. In IBD, this composition is skewed towards ILCs show- problem with a strongly impaired quality of life for the pa- ing anILC1phenotype and cytokineprofile.Thischangeis tients. Until today, the causes and molecular mechanism of the likely due to the microenvironment causing skewing of the disease are not clear and the available treatment regimens are functionally plastic ILC subsets. Interactions between ILCs unsatisfying. A

Journal

Current Allergy and Asthma Reports – Springer Journals

Published: Sep 19, 2016

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