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References (15)
-
K. Mertens, P. Celie, J. Kolkman, P. Lenting (1999)
Factor VIII-Factor IX Interactions: Molecular Sites Involved in Enzyme-Cofactor Complex AssemblyThrombosis and Haemostasis, 82
-
M. Khanin, V. Semenov (1989)
A mathematical model of the kinetics of blood coagulation.Journal of theoretical biology, 136 2
-
R. Leipold, T. Bozarth, A. Racanelli, I. Dicker (1995)
Mathematical Model of Serine Protease Inhibition in the Tissue Factor Pathway to Thrombin (*)The Journal of Biological Chemistry, 270
-
J. Jesty, T. Wun, A. Lorenz (1994)
Kinetics of the inhibition of factor Xa and the tissue factor-factor VIIa complex by the tissue factor pathway inhibitor in the presence and absence of heparin.Biochemistry, 33 42
-
M. Lichtman, J. Spivak, L. Boxer, S. Shattil, E. Henderson (2000)
Commentary on and reprint of Davie EW, Ratnoff OD, Waterfall sequence for intrinsic blood clotting, in Science (1964) 145:1310–1311 -
P. Fay (1999)
Regulation of Factor VIIIa in the Intrinsic Factor XaseThrombosis and Haemostasis, 82
-
C. Veer, S. Butenas, Neal Golden, K. Mann (1999)
Regulation of Prothrombinase Activity by Protein SThrombosis and Haemostasis, 82
-
J. Jesty, E. Beltrami, G. Willems (1993)
Mathematical analysis of a proteolytic positive-feedback loop: dependence of lag time and enzyme yields on the initial conditions and kinetic parameters.Biochemistry, 32 24
-
L. Polgár (1999)
Basic Kinetic Mechanisms of Proteolytic Enzymes -
E. Davie, O. Ratnoff (1964)
Waterfall Sequence for Intrinsic Blood ClottingScience, 145
-
K. Mann, M. Nesheim, W. Church, P. Haley, S. Krishnaswamy (1990)
Surface-dependent reactions of the vitamin K-dependent enzyme complexesBlood, 76
-
EV Jensen (1991)
Biophysical and information transfer in recognition -
KG Mann KC Jones (1994)
A model for the tissue factor fathway to thrombinJ Biol Chem, 269
-
K. Mann (1999)
Biochemistry and Physiology of Blood CoagulationThrombosis and Haemostasis, 82
-
Kenneth Jones, Kenneth Mann (1994)
A model for the tissue factor pathway to thrombin. II. A mathematical simulation.The Journal of biological chemistry, 269 37
- Publisher
- Springer Journals
- Copyright
- 2002 Chinese Journal of Mechanics Press
- ISSN
- 0567-7718
- eISSN
- 1614-3116
- DOI
- 10.1007/BF02487794
- Publisher site
- See Article on Publisher Site
Abstract
Abstract In order to confirm which process is the most important in the blood coagulation cascade, a dynamic model on the function of platelets in blood coagulation is presented based on biochemical experiments. Based on qualitative analysis and mathematical simulation, a series of conclusions about the influence of the activation rate of factor VIII and factor IX on the generation of thrombin (IIa) are drawn. It is evident that the pro-coagulation stimulus must exceed a threshold value to initiate the coagulation cascade. The value is related to the binding constantd 2 of the platelet. The stability of the equilibrium value is also related to the pro-coagulation stimulus. This article also evaluates the influence of the stimulus strength and the activated rate parameter of platelets on thrombin. The proportion of platelets activated at any given time is designatedc. To eachc, we obtain a maximum concentration of thrombin. It is evident that when the level of factor IX is below 1% of the normal level, the rate of thrombin generation reduces dramatically, resulting in severe bleeding tendency.
Journal
"Acta Mechanica Sinica" – Springer Journals
Published: Aug 1, 2002