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- Publisher
- Springer Journals
- Copyright
- Copyright © 2007 by Adis Data Information BV
- Subject
- Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
- ISSN
- 1175-3277
- eISSN
- 1179-187X
- DOI
- 10.2165/00129784-200707001-00004
- pmid
- 19845074
- Publisher site
- See Article on Publisher Site
Abstract
Background: The majority of hypertensive patients require combination therapy to achieve BP goals. Guidelines recommend dual therapy in newly diagnosed patients with BP > 160/100mm Hg. Calcium channel blocker (CCB)/ACE inhibitor and β-blocker (β-adrenoceptor antagonists)/diuretic combinations are among regimens considered effective for BP control. ACE inhibitors, β-blockers, and CCBs arc recommended for use in patients after myocardial infarction (MI). Statistical modeling from INVEST (INternational VErapamil-Trandolapril STudy), suggests an association between dual and triple therapy and decreased risk of primary outcome ([PO] first occurrence of death, nonfatal MI, or nonfatal stroke) in patients with hypertension and coronary artery disease (CAD).
Journal
American Journal of Cardiovascular Drugs – Springer Journals
Published: Dec 9, 2014