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Dopamine measurement during prolonged deep brain stimulation: A proof-of-principle study of paired pulse voltammetry

Dopamine measurement during prolonged deep brain stimulation: A proof-of-principle study of... Biomed Eng Lett (2013) 3:22-31 DOI 10.1007/s13534-013-0086-y ORIGINAL ARTICLE Dopamine Measurement during Prolonged Deep Brain Stimulation: A Proof-of-Principle Study of Paired Pulse Voltammetry Seungleal Brian Paek, Emily Jane Knight, Su-Youne Chang, J. Luis Lujan, Dong Pyo Jang, Kevin E. Bennet and Kendall H. Lee Received: 18 January 2013 / Revised: 28 February 2013 / Accepted: 12 March 2013 © The Korean Society of Medical & Biological Engineering and Springer 2013 Abstract Wireless Instantaneous Neurochemical Concentration Sensing Purpose Deep Brain Stimulation (DBS) has been effective System (WINCS). in treating various neurological and psychiatric disorders; Results Using PPV, the detection of DA was evident throughout however, its underlying mechanism hasn’t been completely the long-term stimulation (5 minutes); however, without PPV, in vivo environmental changes including pH shift eventually understood. Fast scan cyclic voltammetry (FSCV) is a valuable tool to elucidate underlying neurotransmitter mechanisms of obscured the characteristic oxidation current of DA at 0.6V. DBS, due to its sub-second temporal resolution and direct Conclusions These results indicate that PPV can be a valuable identification of analytes. However, since DBS-like high tool to accurately determine DA dynamics in a complex in frequency stimulation evokes neurotransmitter release as well vivo environment during long-term electrical http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biomedical Engineering Letters Springer Journals

Dopamine measurement during prolonged deep brain stimulation: A proof-of-principle study of paired pulse voltammetry

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References (36)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Korean Society of Medical and Biological Engineering and Springer
Subject
Engineering; Biomedical Engineering; Biophysics and Biological Physics; Biomedicine general; Medical and Radiation Physics
ISSN
2093-9868
eISSN
2093-985X
DOI
10.1007/s13534-013-0086-y
Publisher site
See Article on Publisher Site

Abstract

Biomed Eng Lett (2013) 3:22-31 DOI 10.1007/s13534-013-0086-y ORIGINAL ARTICLE Dopamine Measurement during Prolonged Deep Brain Stimulation: A Proof-of-Principle Study of Paired Pulse Voltammetry Seungleal Brian Paek, Emily Jane Knight, Su-Youne Chang, J. Luis Lujan, Dong Pyo Jang, Kevin E. Bennet and Kendall H. Lee Received: 18 January 2013 / Revised: 28 February 2013 / Accepted: 12 March 2013 © The Korean Society of Medical & Biological Engineering and Springer 2013 Abstract Wireless Instantaneous Neurochemical Concentration Sensing Purpose Deep Brain Stimulation (DBS) has been effective System (WINCS). in treating various neurological and psychiatric disorders; Results Using PPV, the detection of DA was evident throughout however, its underlying mechanism hasn’t been completely the long-term stimulation (5 minutes); however, without PPV, in vivo environmental changes including pH shift eventually understood. Fast scan cyclic voltammetry (FSCV) is a valuable tool to elucidate underlying neurotransmitter mechanisms of obscured the characteristic oxidation current of DA at 0.6V. DBS, due to its sub-second temporal resolution and direct Conclusions These results indicate that PPV can be a valuable identification of analytes. However, since DBS-like high tool to accurately determine DA dynamics in a complex in frequency stimulation evokes neurotransmitter release as well vivo environment during long-term electrical

Journal

Biomedical Engineering Letters – Springer Journals

Published: Apr 14, 2013

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