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Cardiol Ther (2017) 6:129–132 DOI 10.1007/s40119-016-0075-1 BRIEF REPORT Does Gender Influence the Cardiovascular Benefits Observed with Sodium Glucose Co-Transporter-2 (SGLT-2) Inhibitors? A Meta-Regression Analysis . . . Ahmed N. Mahmoud Islam Y. Elgendy Marwan Saad . . . . Akram Y. Elgendy Amr F. Barakat Amgad Mentias Ahmed Abuzaid Anthony A. Bavry Received: October 20, 2016 / Published online: November 28, 2016 The Author(s) 2016. This article is published with open access at Springerlink.com in the patients with type 2 diabetes mellitus ABSTRACT receiving SGLT-2 inhibitors. Introduction: Although a large recent trial had Methods: A search of electronic databases was shown improved cardiovascular outcomes of conducted for all randomized trials comparing diabetic patients on sodium glucose SGLT-2 inhibitors with placebo in patients with co-transporter-2 (SGLT-2) inhibitors, the diabetes mellitus. Primary outcomes were influence of gender differences on such all-cause mortality and cardiovascular outcomes is not known. Thus, we aimed to mortality. Random effects meta-regression was assess the impact of gender on such outcomes conducted using the percentage of women included in the SGLT-2 inhibitor arm of each trial with a P value of \0.1 for statistical Enhanced content To view enhanced content for this significance. article go to http://www.medengine.com/Redeem/1627
Cardiology and Therapy – Springer Journals
Published: Nov 28, 2016
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