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Disruption of telomere homeostasis as a new cancer treatment strategy

Disruption of telomere homeostasis as a new cancer treatment strategy Telomeres are critical for the protection of chromosomal ends and genomic integrity. Telomeres can be maintained by their associated proteins (collectively termed as telosome or shelterin) as well as the telomerase complex containing a reverse transcriptase component. While most somatic human cells lack telomerase activity to sufficiently maintain telomeres, the majority of all cancer cells express telomerase activity. The maintenance of telomeres contributes to the immortal phenotype seen in most cancers. Therefore, it has been proposed that targeting telomere maintenance should result in a highly specific and universal treatment for cancer. Here the topic of targeting the immortal phenotype of cancer by disrupting telomere homeostasis is discussed as well as the current status, and challenges, of clinical trials. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png memo - Magazine of European Medical Oncology Springer Journals

Disruption of telomere homeostasis as a new cancer treatment strategy

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Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer-Verlag
Subject
Medicine & Public Health; Oncology; Medicine/Public Health, general
ISSN
1865-5041
eISSN
1865-5076
DOI
10.1007/s12254-008-0080-8
Publisher site
See Article on Publisher Site

Abstract

Telomeres are critical for the protection of chromosomal ends and genomic integrity. Telomeres can be maintained by their associated proteins (collectively termed as telosome or shelterin) as well as the telomerase complex containing a reverse transcriptase component. While most somatic human cells lack telomerase activity to sufficiently maintain telomeres, the majority of all cancer cells express telomerase activity. The maintenance of telomeres contributes to the immortal phenotype seen in most cancers. Therefore, it has been proposed that targeting telomere maintenance should result in a highly specific and universal treatment for cancer. Here the topic of targeting the immortal phenotype of cancer by disrupting telomere homeostasis is discussed as well as the current status, and challenges, of clinical trials.

Journal

memo - Magazine of European Medical OncologySpringer Journals

Published: Jan 1, 2008

References