Access the full text.
Sign up today, get DeepDyve free for 14 days.
T. Charman, Emma Taylor, Auriol Drew, H. Cockerill, Jodie Brown, G. Baird (2005)
Outcome at 7 years of children diagnosed with autism at age 2: predictive validity of assessments conducted at 2 and 3 years of age and pattern of symptom change over time.Journal of child psychology and psychiatry, and allied disciplines, 46 5
T. Price, B. Freeman, I. Craig, S. Petrill, Lorna Ebersole, R. Plomin (2000)
Infant zygosity can be assigned by parental report questionnaire data.Twin research : the official journal of the International Society for Twin Studies, 3 3
F. Steensel, S. Bögels, S. Perrin (2011)
Anxiety Disorders in Children and Adolescents with Autistic Spectrum Disorders: A Meta-AnalysisClinical Child and Family Psychology Review, 14
K. Kendler, C. Gardner, P. Lichtenstein (2008)
A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuationPsychological Medicine, 38
T. Eley, D. Bolton, T. O’Connor, S. Perrin, Patrick Smith, R. Plomin (2003)
A twin study of anxiety-related behaviours in pre-school children.Journal of child psychology and psychiatry, and allied disciplines, 44 7
C Allison, J Williams, F Scott, C Stott, P Bolton, S Baron-Cohen, C Brayne (2007)
The Childhood Asperger Syndrome Test (CAST): test-retest reliability in a high scoring sampleAutism, 11
K. Gadow, C. Devincent, J. Pomeroy, A. Azizian (2005)
Comparison of DSM-IV symptoms in elementary school-age children with PDD versus clinic and community samplesAutism, 9
Scott Bellini (2004)
Social Skill Deficits and Anxiety in High-Functioning Adolescents With Autism Spectrum DisordersFocus on Autism and Other Developmental Disabilities, 19
J. Loehlin (1996)
The Cholesky approach: A cautionary noteBehavior Genetics, 26
Bonamy Oliver, R. Plomin (2007)
Twins' Early Development Study (TEDS): A Multivariate, Longitudinal Genetic Investigation of Language, Cognition and Behavior Problems from Childhood Through AdolescenceTwin Research and Human Genetics, 10
M. Baron, J. Groden, G. Groden, Lewis Lipsitt (2006)
Stress and Coping in Autism
(2003)
MX: statistical modeling (6th ed.). Richmond: Department of Psychiatry, Medical College of Virginia
J. Hettema, M. Neale, J. Myers, C. Prescott, K. Kendler (2006)
A population-based twin study of the relationship between neuroticism and internalizing disorders.The American journal of psychiatry, 163 5
D. Pine, A. Guyer, Michelle Goldwin, Kenneth Towbin, E. Leibenluft (2008)
Autism spectrum disorder scale scores in pediatric mood and anxiety disorders.Journal of the American Academy of Child and Adolescent Psychiatry, 47 6
Angelica Ronald, Henrik Larsson, H. Anckarsäter, Paul Lichtenstein (2011)
A twin study of autism symptoms in SwedenMolecular Psychiatry, 16
F. Happé, A. Ronald, R. Plomin (2006)
Time to give up on a single explanation for autismNature Neuroscience, 9
Victoria Hallett, A. Ronald, F. Happé (2009)
Investigating the association between autistic-like and internalizing traits in a community-based twin sample.Journal of the American Academy of Child and Adolescent Psychiatry, 48 6
A. Ronald, F. Happé, T. Price, S. Baron-Cohen, R. Plomin (2006)
Phenotypic and genetic overlap between autistic traits at the extremes of the general population.Journal of the American Academy of Child and Adolescent Psychiatry, 45 10
A. Kolevzon, Christopher Smith, J. Schmeidler, J. Buxbaum, J. Silverman (2004)
Familial symptom domains in monozygotic siblings with autismAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 129B
K. Kendler, C. Gardner, P. Annas, M. Neale, L. Eaves, P. Lichtenstein (2008)
A longitudinal twin study of fears from middle childhood to early adulthood: evidence for a developmentally dynamic genome.Archives of general psychiatry, 65 4
(1964)
THE PRESENTATION OF DEPRESSIONMedical Journal of Australia, 1
Victoria Hallett, A. Ronald, F. Rijsdijk, T. Eley (2009)
Phenotypic and genetic differentiation of anxiety‐related behaviors in middle childhoodDepression and Anxiety, 26
S. White, D. Oswald, T. Ollendick, L. Scahill (2009)
Anxiety in children and adolescents with autism spectrum disorders.Clinical psychology review, 29 3
A. Ronald, F. Happé, P. Bolton, L. Butcher, T. Price, S. Wheelwright, S. Baron-Cohen, R. Plomin (2006)
Genetic heterogeneity between the three components of the autism spectrum: a twin study.Journal of the American Academy of Child and Adolescent Psychiatry, 45 6
Mary Stewart, L. Barnard, J. Pearson, Reem Hasan, G. O'brien (2006)
Presentation of depression in autism and Asperger syndromeAutism, 10
W. Mandy, D. Skuse (2008)
Research review: What is the association between the social-communication element of autism and repetitive interests, behaviours and activities?Journal of child psychology and psychiatry, and allied disciplines, 49 8
Jo Williams, C. Allison, F. Scott, C. Stott, P. Bolton, S. Baron-Cohen, C. Brayne (2006)
The Childhood Asperger Syndrome Test (CAST)Autism, 10
W. Hirstein, P. Iversen, V. Ramachandran (2001)
Autonomic responses of autistic children to people and objectsProceedings of the Royal Society of London. Series B: Biological Sciences, 268
A. Ronald, R. Hoekstra (2011)
Autism spectrum disorders and autistic traits: A decade of new twin studiesAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 156
(2008)
Behavioral genetics (5th ed.)
B. Chorpita, Letitia Yim, C. Moffitt, Lori Umemoto, Sarah Francis (2000)
Assessment of symptoms of DSM-IV anxiety and depression in children: a revised child anxiety and depression scale.Behaviour research and therapy, 38 8
P Muris, H Merckelbach, B Mayer, A Brakel, S Thissen, V Moulaert, B Gadet (1998)
The Screen for Child Anxiety Related Emotional Disorders (SCARED) and traditional childhood anxiety measures. Comparative studyJournal of Behavior Therapy and Experimental Psychiatry, 29
Y. Sung, G. Dawson, J. Munson, A. Estes, G. Schellenberg, E. Wijsman (2005)
Genetic investigation of quantitative traits related to autism: use of multivariate polygenic models with ascertainment adjustment.American journal of human genetics, 76 1
Emily Russell, K. Sofronoff (2005)
Anxiety and social worries in children with Asperger syndrome.The Australian and New Zealand journal of psychiatry, 39 7
Ainslie Rosbrook, K. Whittingham (2010)
Autistic traits in the general population: What mediates the link with depressive and anxious symptomatology?Research in Autism Spectrum Disorders, 4
M Neale, S Boker, G Xie, H Maes (2003)
MX: statistical modeling
R. Hoekstra, M. Bartels, J. Hudziak, T. Beijsterveldt, D. Boomsma (2007)
Genetic and Environmental Covariation Between Autistic Traits and Behavioral ProblemsTwin Research and Human Genetics, 10
M. Neale, E. Røysamb, K. Jacobson (2006)
Multivariate Genetic Analysis of Sex Limitation and G × E InteractionTwin Research and Human Genetics, 9
D. Evans, Kristin Canavera, F. Kleinpeter., E. Maccubbin, Ken Taga (2005)
The Fears, Phobias and Anxieties of Children with Autism Spectrum Disorders and Down Syndrome: Comparisons with Developmentally and Chronologically Age Matched ChildrenChild Psychiatry and Human Development, 36
J Williams, C Allison, F Scott, C Stott, P Bolton, S Baron-Cohen, C Brayne (2006)
The Childhood Asperger Syndrome Test (CAST): test-retest reliabilityAutism, 10
F. Rijsdijk, P. Sham (2002)
Analytic approaches to twin data using structural equation modelsBriefings in bioinformatics, 3 2
Victoria Hallett, A. Ronald, F. Rijsdijk, F. Happé (2010)
Association of autistic-like and internalizing traits during childhood: a longitudinal twin study.The American journal of psychiatry, 167 7
Ovsanna Leyfer, S. Folstein, S. Bacalman, Naomi Davis, Elena Dinh, J. Morgan, H. Tager-Flusberg, J. Lainhart (2006)
Comorbid Psychiatric Disorders in Children with Autism: Interview Development and Rates of DisordersJournal of Autism and Developmental Disorders, 36
S. Kuusikko, Rachel Pollock-Wurman, Katja Jussila, A. Carter, M. Mattila, H. Ebeling, D. Pauls, I. Moilanen (2008)
Social Anxiety in High-functioning Children and Adolescents with Autism and Asperger SyndromeJournal of Autism and Developmental Disorders, 38
P. Muris, H. Merckelbach, B. Mayer, A. Brakel, Sandra Thissen, V. Moulaert, Björn Gadet (1998)
The Screen for Child Anxiety Related Emotional Disorders (SCARED) and traditional childhood anxiety measures.Journal of behavior therapy and experimental psychiatry, 29 4
J. Matson, S. Love (1990)
A comparison of parent-reported fear for autistic and nonhandicapped age-matched children and youth, 16
J. Constantino, J. Hudziak, R. Todd (2003)
Deficits in reciprocal social behavior in male twins: evidence for a genetically independent domain of psychopathology.Journal of the American Academy of Child and Adolescent Psychiatry, 42 4
K. Towbin, Anne Pradella, T. Gorrindo, D. Pine, E. Leibenluft (2005)
Autism spectrum traits in children with mood and anxiety disorders.Journal of child and adolescent psychopharmacology, 15 3
S. Curran, K. Dworzynski, F. Happé, A. Ronald, C. Allison, S. Baron-Cohen, C. Brayne, P. Bolton (2011)
No major effect of twinning on autistic traitsAutism Research, 4
S. Willemsen-Swinkels, J. Buitelaar, M. Dekker, H. Engeland (1998)
Subtyping Stereotypic Behavior in Children: The Association Between Stereotypic Behavior, Mood, and Heart RateJournal of Autism and Developmental Disorders, 28
A. Ronald, F. Happé, R. Plomin (2005)
The genetic relationship between individual differences in social and nonsocial behaviours characteristic of autism.Developmental science, 8 5
S. White, R. Roberson-Nay (2009)
Anxiety, Social Deficits, and Loneliness in Youth with Autism Spectrum DisordersJournal of Autism and Developmental Disorders, 39
D. Sukhodolsky, L. Scahill, K. Gadow, L. Arnold, M. Aman, C. McDougle, J. McCracken, E. Tierney, Susan White, L. Lecavalier, B. Vitiello (2008)
Parent-Rated Anxiety Symptoms in Children with Pervasive Developmental Disorders: Frequency and Association with Core Autism Symptoms and Cognitive FunctioningJournal of Abnormal Child Psychology, 36
Joanna Williams, C. Allison, F. Scott, P. Bolton, S. Baron-Cohen, F. Matthews, C. Brayne (2008)
The Childhood Autism Spectrum Test (CAST): Sex DifferencesJournal of Autism and Developmental Disorders, 38
ME Stewart, L Barnard, J Pearson, R Hasan, G O’Brien (2006)
Presentation of depression in autism and Asperger syndrome: a reviewAutism, 10
Internalizing difficulties are prevalent in children with autism spectrum disorders (ASD), yet little is known about the underlying cause of this comorbidity. It is also unclear which types of autistic-like and internalizing difficulties are most strongly associated. The current study investigated the phenotypic and etiological associations between specific autistic-like traits and internalizing traits within a population-based sample. Parent-reported data were analyzed from 7,311 twin pairs at age 7 to 8 years. Structural equation modeling revealed distinguishable patterns of overlap between the three autistic-like traits (social difficulties, communication problems and repetitive/restricted behaviors) and four subtypes of internalizing traits (social anxiety, fears, generalized anxiety, negative affect). Although all phenotypic associations were modest (rph = 0.00–0.36), autistic-like communication impairments and repetitive/restricted behaviors correlated most strongly with generalized anxiety and negative affect both phenotypically and genetically. Conversely, autistic-like social difficulties showed little overlap with internalizing behaviors. Disentangling these associations and their etiological underpinnings may help contribute to the conceptualization and diagnosis of ‘comorbidity’ within ASD and internalizing disorders.
Journal of Abnormal Child Psychology – Springer Journals
Published: Dec 10, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.