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Direct electrochemical reduction of ethyl isonicotinate to 4-pyridinemethanol in an undivided flow reactor

Direct electrochemical reduction of ethyl isonicotinate to 4-pyridinemethanol in an undivided... 4-pyridinemethanol is well known as an important pharmaceutical intermediate and chemical raw material. Its preparation by electrochemical method has seen a recent explosion of interest. In this paper, we report the synthesis of 4-pyridinemethanol by electrochemical reduction of ethyl isonicotinate using an undivided flow electrolysis cell. The experiments were conducted under different conditions, including applied charge, initial concentration of ethyl isonicotinate and H2SO4, current density, and electrode materials. The yield of 4-pyridinemethanol reached up to 71 % under the optimal conditions. The oxidation of target product was avoided by using Ti/IrO2 anode in the absence of membrane separation. Furthermore, the repeat cycle experiments and cyclic voltammetric experiments showed that this approach possessed good reproducibility and stability. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Direct electrochemical reduction of ethyl isonicotinate to 4-pyridinemethanol in an undivided flow reactor

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Publisher
Springer Journals
Copyright
Copyright © Akadémiai Kiadó 2021
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-021-00206-w
Publisher site
See Article on Publisher Site

Abstract

4-pyridinemethanol is well known as an important pharmaceutical intermediate and chemical raw material. Its preparation by electrochemical method has seen a recent explosion of interest. In this paper, we report the synthesis of 4-pyridinemethanol by electrochemical reduction of ethyl isonicotinate using an undivided flow electrolysis cell. The experiments were conducted under different conditions, including applied charge, initial concentration of ethyl isonicotinate and H2SO4, current density, and electrode materials. The yield of 4-pyridinemethanol reached up to 71 % under the optimal conditions. The oxidation of target product was avoided by using Ti/IrO2 anode in the absence of membrane separation. Furthermore, the repeat cycle experiments and cyclic voltammetric experiments showed that this approach possessed good reproducibility and stability.

Journal

Journal of Flow ChemistrySpringer Journals

Published: Jun 1, 2022

Keywords: Electrosynthesis; Reduction; Ethyl isonicotinate; 4-pyridinemethanol; Flow electrochemistry

References