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ISSN 00125008, Doklady Chemistry, 2014, Vol. 457, Part 2, pp. 154–159. © Pleiades Publishing, Ltd., 2014. Original Russian Text © I.A. Tumanov, A.F. Achkasov, S.A. Myz, E.V. Boldyreva, V.V. Boldyrev, 2014, published in Doklady Akademii Nauk, 2014, Vol. 457, No. 6, pp. 670–675. CHEMISTRY Different Effect of Impact and Shear Mechanical Treatment on Mechanochemical Cocrystallization of Piroxicam and Succinic Acid a, b b a I. A. Tumanov , A. F. Achkasov , S. A. Myz , a, b a, b E. V. Boldyreva , and Academician V. V. Boldyrev Received April 2, 2014 DOI: 10.1134/S0012500814080059 Synthesis of twocomponent crystals based on efficiencies but also lead to qualitatively different drugs and organic acids (cocrystals) is currently one of results. In the same system, impact treatment led to the most promising methods of fabrication of new, synthesis of a cocrystals from the component phases, improved, pharmaceuticals [1]. Joint mechanical whereas shear treatment led to the decomposition of treatment of a mixture of components in a mill or even cocrystals into the components. in a hand mortar is more and more widely used for Cocrystals with the piroxicam : succinic acid molar their synthesis [2]. Mechanochemical treatment is not ratio of 2
Doklady Chemistry – Springer Journals
Published: Sep 2, 2014
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