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I. Koplovitz, R. Menton, C. Matthews, M. Shutz, C. Nalls, S. Kelly (1995)
Dose-response effects of atropine and HI-6 treatment of organophosphorus poisoning in guinea pigs.Drug and chemical toxicology, 18 2-3
D. Hanke, M. Beckett, M. Overton, C. Burdick, C. Lieske (1990)
Oxime‐induced reactivation of acetylcholinesterase inhibited by organophosphinatesJournal of Applied Toxicology, 10
D. Maxwell, I. Koplovitz (1990)
Effect of endogenous carboxylesterase on HI-6 protection against soman toxicity.The Journal of pharmacology and experimental therapeutics, 254 2
L. Ševelová, K. Kuča, G. Krejčová, J. Vachek (2004)
The therapeutic efficacy of oxime treatment in cyclosarin- poisoned mice pretreated with a combination of pyridostigmine benactyzine and trihexyphenidylJournal of Applied Biomedicine, 2
R. Kusic, B. Bošković, V. Vojvodić, D. Jovanović (1985)
HI-6 in man: blood levels, urinary excretion, and tolerance after intramuscular administration of the oxime to healthy volunteers.Fundamental and applied toxicology : official journal of the Society of Toxicology, 5 6 Pt 2
F. Worek, T. Kirchner, L. Szinicz (2007)
Treatment of tabun poisoned guinea-pigs with atropine, HLö 7 or HI 6: effect on respiratory and circulatory functionArchives of Toxicology, 68
I. Koplovitz, V. Gresham, L. Dochterman, A. Kaminskis, J. Stewart (2005)
Evaluation of the toxicity, pathology, and treatment of cyclohexylmethylphosphonofluoridate (CMPF) poisoning in rhesus monkeysArchives of Toxicology, 66
A Goransson-Nyberg, G Cassel, T Jeneskog (1995)
Treatment of organophosphate poisoning in pigs: antidote administration by a new autoinjectorArch Toxicol, 70
C-T Su, CP Tang, C Ma (1983)
Quantitative structure-activity relationships and possible mechanisms of action of bis-pyridinium oximes as antidotes against pinacolyl methylphosphonofluoridateFundam Appl Toxicol, 3
P. Lundy, K. Tremblay (1979)
Ganglion blocking properties of some bispyridinium soman antagonists.European journal of pharmacology, 60 1
L. Bartošová, G. Kunešová, K. Kuča, J. Vachek (2004)
Therapeutic efficacy of different antidotal mixtures against poisoning with GF-agent in mice.Acta medica, 47 4
J Lipp, T Dola (1980)
Comparison of the efficay of HS-6 versus HI-6 when combined with atropine, pyridostgmine and clonazeam for soman poisoning in the monkeyArch Int Pharmacodyn Ther, 246
C. Luo, J. Liang (1997)
Evaluation of combined toxic effects of GB/GF and efficacy of jielin injection against combined poisoning in mice.Toxicology letters, 92 3
D. Jovanović, S. Randjelovic, D. Joksovic (1990)
A Case of Unusual Suicidal Poisoning by the Organophosphorus Insecticide DimethoateHuman & Experimental Toxicology, 9
C. Su, C. Tang, Chong Ma, Y. Shih, Chong-Yean Liu, Mou-Thai Wu (1983)
Quantitative Structure-Activity Relationships and Possible Mechanisms of Action of Bispyridinium Oximes as Antidotes Against Pinacolyl MethylphosphonofluoridateToxicological Sciences, 3
J Kassa, J Cabal, J Bajgar (1997)
The choice: HI-6 pralidoxime or obidoxime against nerve agents?ASA Newsl, 4
TM Shih, S Harris, K Henry (1986)
Relationship between soman-induced elevation of brain regional acetylcholine concentrations and lethalitySoc Neurosci, 12
R. Busker, J. Zijlstra, I. Philippens, B. Groen, B. Melchers (1996)
Comparison of the efficacy of single or repeated HI-6 treatment following soman poisoning in guinea pigs and marmoset monkeys.Toxicology, 112 3
C. Bedford, R. Howd, O. Dailey, A. Miller, H. Nolen, R. Kenley, J. Kern, J. Winterle (1986)
Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.Journal of medicinal chemistry, 29 11
R. Inns, L. Leadbeater (1983)
The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea‐pigJournal of Pharmacy and Pharmacology, 35
M. Hamilton, P. Lundy (2004)
HI-6 therapy of soman and tabun poisoning in primates and rodentsArchives of Toxicology, 63
K Kuca, L Bartosova, D Jun (2005)
New quaternary pyridine aldoximes as causal antidotes against nerve agent intoxicationsBiomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 149
K. Kuča, J. Patočka (2004)
Reactivation of Cyclosarin-inhibited Rat Brain Acetylcholinesterase by Pyridinium–OximesJournal of Enzyme Inhibition and Medicinal Chemistry, 19
Y Kloog, M Sokolovsky (1985)
Bispyridinium oximes as allosteric inhibitors of rat brain muscarinic receptorsMol Pharmacol, 27
C. Olson, R. Menton, J. Blank, D. Hobson (1997)
An Automated Method for the Analysis of MethemoglobinInternational Journal of Toxicology, 16
R. Kusic, D. Jovanović, S. Randjelovic, D. Joksovic, V. Todorović, B. Bošković, M. Jokanović, V. Vojvodić (1991)
HI-6 in Man: Efficacy of the Oxime in Poisoning by Organophosphorus InsecticidesHuman and Experimental Toxicology, 10
Krummer S., T. H., Worek F., Eyer P. (2002)
Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonateArchives of Toxicology, 76
P. Lundy, B. Hand, B. Broxup, G. Yipchuck, M. Hamilton (2005)
Distribution of the bispyridinium oxime [14C] HI-6 in male and female ratsArchives of Toxicology, 64
P. Lundy (1999)
Treatment of Organophosphate Nerve Agents, Current Therapy and Future Prospectives
M. Škrinjarić-Špoljar, M. Kralj (1980)
Reactivating and protective effects of pyridinium compounds in human erythrocyte acetylcholinesterase inhibition by organophosphates in vitroArchives of Toxicology, 45
Maja Čalić, A. Vrdoljak, B. Radić, Dubravko Jelić, D. Jun, K. Kuča, Z. Kovarik (2006)
In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.Toxicology, 219 1-3
GE Cassel, P Fosbraey (1996)
Measurement of the oxime HI-6 in tandem with neurotransmitter levels in striatal dialysates: effects of soman intoxicationJ Pharmacol Toxicol Methods, 35
H. Edery, M. Geyer, P. Taylor, H. Berman (1986)
Target sites for anticholinesterases on the ventral surface of the medulla oblongata: hypotension elicited by organophosphorus agents.Journal of autonomic pharmacology, 6 3
Sadayoshi Ohbu, Akira Yamashina, N. Takasu, Tatsuo Yamaguchi, Tetsuo Murai, Kanzoh Nakano, Yukio Matsui, R. Mikami, Kenji Sakurai, Shigeaki Hinohara (1997)
Sarin poisoning on Tokyo subway.Southern medical journal, 90 6
A. Štalc, M. Sentjurc (1990)
A contribution to the mechanism of action of SAD-128.Biochemical pharmacology, 40 11
T. Shih (2005)
Comparison of several oximes on reactivation of soman-inhibited blood, brain and tissue cholinesterase activity in ratsArchives of Toxicology, 67
T. Shih, C. Whalley, J. Valdés, P. Lundy, P. Lockwood (1986)
Cholinergic Effects of HI-6 in Soman Poisoning
Leo Jong, G. Wolring (1980)
Reactivation of acetylcholinesterase inhibited by 1,2,2'-trimethylpropyl methylphosphonofluoridate (soman) with HI-6 and related oximes.Biochemical pharmacology, 29 17
K Schoene, H Oldiges (1973)
The effets of pyridinium salts in tabun and sarin intoxications in vivo and in vitroArch Int Pharmacodyn, 204
M. French, J. Wetherell, P. White (1983)
The reversal by oximes and their de oximinomethyl analogues of neuromuscular block produced by soman.European journal of pharmacology, 91 4
J. Kassa (2004)
[Effect of acetylcholinesterase reactivator dosage on its effectiveness in the treatment of tabun poisoning in mice].Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 53 1
P. Lundy, I. Hill, P. Lecavalier, M. Hamilton, C. Vair, C. Davidson, K. Weatherby, B. Berger (2005)
The pharmacokinetics and pharmacodynamics of two HI-6 salts in swine and efficacy in the treatment of GF and soman poisoning.Toxicology, 208 3
Paul Lundy, A. Hansen, B. Hand, Camille Boulet (1992)
Comparison of several oximes against poisoning by soman, tabun and GF.Toxicology, 72 1
A. Dekleva, D. Sket, J. Sketelj, M. Brzin (2004)
Attenuation of soman-induced lesions of skeletal muscle by acetylcholinesterase reactivating and non-reactivating antidotesActa Neuropathologica, 79
A. Smith, H. Wiel, O. Wolthuis (1981)
Analysis of oxime-induced neuromuscular recovery in guinea pig, rat and man following soman poisoning in vitro.European journal of pharmacology, 70 3
P. Lundy, R. Shaw (1983)
Modification of cholinergically induced convulsive activity and cyclic GMP levels in the CNSNeuropharmacology, 22
D. Quinn, A. Balasubramanian, B. Doctor, P. Taylor (1995)
Enzymes of the Cholinesterase Family
K. Kuča, L. Bartošová, D. Jun, J. Patočka, J. Cabal, J. Kassa, G. Kunešová (2005)
New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications.Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 149 1
N. Weger, L. Szinicz (1981)
Therapeutic effects of new oximes, benactyzine and atropine in Soman poisoning: Part I. Effects of various oximes in Soman, Sarin, and Vx poisoning in dogs.Fundamental and applied toxicology : official journal of the Society of Toxicology, 1 2
Y. Kloog, R. Galron, D. Balderman, M. Sokolovsky (1985)
Reversible and irreversible inhibition of rat brain muscarinic receptors is related to different substitutions on bisquaternary pyridinium oximesArchives of Toxicology, 58
Z. Grubic, Anton Tomažič (2004)
Mechanism of action of HI-6 on soman inhibition of acetylcholinesterase in preparations of rat and human skeletal muscle; comparison to SAD-128 and PAM-2Archives of Toxicology, 63
H. Helden, H. Wiel, O. Wolthuis (1983)
Therapy of organophosphate poisoning: the marmoset as a model for manBritish Journal of Pharmacology, 78
K. Kuča, L. Bartošová, J. Kassa, J. Cabal, J. Bajgar, G. Kunešová, D. Jun (2005)
(09) Comparison of the potency of newly developed and currently available oximes to reactivate nerve agent-inhibited acetylcholinesterase in vitro and in vivoChemico-Biological Interactions, 157
Y. Kloog, M. Sokolovsky (1985)
Bisquaternary pyridinium oximes as allosteric inhibitors of rat brain muscarinic receptors.Molecular pharmacology, 27 4
J. Clement, D. Bailey, H. Madill, L. Tran, J. Spence (1995)
The acetylcholinesterase oxime reactivator HI‐6 in man: Pharmacokinetics and tolerability in combination with atropineBiopharmaceutics & Drug Disposition, 16
DM Maxwell, KM Brecht, I Koplovitz (1997)
Characterization and treatment of the toxicity of o-isobutyl S-[(diethylamino)ethyl] methylphosphonothiolate, a structural analogue of VX in guinea pigsJ Am Coll Toxicol, 15
MG Hamilton, PM Lundy (1986)
Efficacy of HI-6 against soman and tabun challenges in primates and rodents
P. Lundy, T. Shih (1983)
Examination of the Role of Central Cholinergic Mechanisms in the Therapeutic Effects of HI‐6 in Organophosphate PoisoningJournal of Neurochemistry, 40
I. Hanin (1986)
Dynamics of Cholinergic Function
D. Ligtenstein, G. Moes, S. Kossen (1988)
In vivo distribution of organophosphate antidotes: autoradiography of [14C]HI-6 in the rat.Toxicology and applied pharmacology, 92 2
Z Binenfeld, M Maksimović, V Deljac (1982)
New in vitro method for screening antisoman activity of antidotesActa Pharm Jugosl, 32
Jiří Kassa (2002)
Review of Oximes in the Antidotal Treatment of Poisoning by Organophosphorus Nerve AgentsJournal of Toxicology: Clinical Toxicology, 40
M. Adler, D. Maxwell, M. Filbert, S. Deshpande (1994)
Contribution of direct actions of the oxime HI-6 in reversing soman-induced muscle weakness in the rat diaphragm.European journal of pharmacology, 270 1
L. Harris, D. Anderson, W. Lennox, C. Woodard, A. Pastelak, B. Vanderpool (1990)
Evaluation of several oximes as reactivators of unaged soman-inhibited whole blood acetylcholinesterase in rabbits.Biochemical pharmacology, 40 12
B. Bošković, V. Kovacevic, D. Jovanović (1984)
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning.Fundamental and applied toxicology : official journal of the Society of Toxicology, 4 2 Pt 2
D. Maxwell, K. Brecht (1991)
The role of carboxylesterase in species variation of oxime protection against somanNeuroscience & Biobehavioral Reviews, 15
M. Alkondon, K. Rao, E. Albuquerque (1988)
Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel.The Journal of pharmacology and experimental therapeutics, 245 2
MG Hamilton (1990)
HI-6 as an antidote to organophosphate poisoning rhesus monkey
S. Wiener, R. Hoffman (2004)
Nerve Agents: A Comprehensive ReviewJournal of Intensive Care Medicine, 19
J. Clement (1981)
Toxicology and pharmacology of bispyridium oximes--insight into the mechanism of action vs Soman poisoning in vivo.Fundamental and applied toxicology : official journal of the Society of Toxicology, 1 2
K. Kuča, D. Jun, J. Cabal, M. Hrabinová, L. Bartošová, V. Opletalová (2006)
Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent.Basic & clinical pharmacology & toxicology, 98 4
K. Schoene, H. Oldiges (1973)
[Efficacy of pyridinium salts in tabun and sarin poisoning in vivo and in vitro].Archives internationales de pharmacodynamie et de therapie, 204 1
R. Chen, L. Raveh, G. Zomber, I. Rabinovitz, G. Cohen, R. Adani, G. Amitai (2001)
Determination of therapeutic doses of bisquaternary oximes in large animalsJournal of Applied Toxicology, 21
BP Melchers, AL Laaken, RW Busker (1994)
Non-reactivating effects of HI-6 on hippocampal neurotransmissionArch Toxicol, 69
H. Helden, J. Lange, R. Busker, B. Melchers (2005)
Therapy of organophosphate poisoning in the rat by direct effects of oximes unrelated to ChE reactivationArchives of Toxicology, 65
J. Clement (2006)
Efficacy of various oximes against GF (cyclohexyl methylphosphonofluoridate) poisoning in miceArchives of Toxicology, 66
D. Sket, M. Brzin (1986)
Effect of HI-6, applied into the cerebral ventricles, on the inhibition of brain acetylcholinesterase by soman in ratsNeuropharmacology, 25
JG Clement (1983)
Efficacy of mono and bispyridinium oximes versus soman sarin and tabun poisoning in miceFundam Appl Toxicol, 3
J. Tattersall (1993)
Ion channel blockade by oximes and recovery of diaphragm muscle from soman poisoning in vitroBritish Journal of Pharmacology, 108
H. Helden, H. Wiel, J. Lange, R. Busker, B. Melchers, O. Wolthuis (1992)
Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys.Toxicology and applied pharmacology, 115 1
A. Smith, O. Wolthuis (1983)
HI6 as an antidote to soman poisoning in rhesus monkey respiratory muscles in‐vitroJournal of Pharmacy and Pharmacology, 35
L. Jong, G. Wolring (1985)
Aging and stereospecific reactivation of mouse erythrocyte and brain acetylcholinesterases inhibited by soman.Biochemical pharmacology, 34 1
J. Kassa (1998)
[Comparison of the reactivation effects of the HI-6 oxime and obidoximeon cyclosin-inhibited acetylcholinesterase in the diaphragm and various parts of the brain in rats].Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 47 1
T. Sohns, V. Voicu, L. Szinicz, E. Finke, C. Mircioiu, P. Lundy, K. Brain, Harald Kempf (1999)
NBC Risks Current Capabilities and Future Perspectives for Protection
D Jovanović, S Randjelović, D Joksović (1993)
Pharmacokinetics of the oxime HI-6 in patients with acute insecticide poisoningVojnosanit Preg, 501
G. Cassel, L. Karlsson, LENA Waara, K. Ang, A. Göransson-Nyberg (1997)
Pharmacokinetics and effects of HI 6 in blood and brain of soman-intoxicated rats: a microdialysis study.European journal of pharmacology, 332 1
F. Worek, H. Thiermann, L. Szinicz, P. Eyer (2004)
Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes.Biochemical pharmacology, 68 11
H. Thiermann, S. Seidl, P. Eyer (1996)
HI 6 dimethanesulfonate has better dissolution properties than HI 6 dichloride for application in dry/wet autoinjectors☆International Journal of Pharmaceutics, 137
B. Melchers, A. Laaken, H. Helden (1991)
On the mechanism whereby HI-6 improves neuromuscular function after oxime-resistant acetylcholinesterase inhibition and subsequent impairment of neuromuscular transmission.European journal of pharmacology, 200 2-3
J. Valdés, T. Shih, C. Whalley (1985)
Competitive binding of the oximes HI-6 and 2-PAM with regional brain muscarinic receptors.Biochemical pharmacology, 34 15
C Luo, M Tong, DM Maxwell (2006)
Aging and oxime induced reactivation of nerve agent inhibited human and guinea pig acetylcholinesterases
R. Dawson (1994)
Review of oximes available for treatment of nerve agent poisoningJournal of Applied Toxicology, 14
R. Klimmek, P. Eyer (1986)
Pharmacokinetics and pharmacodynamics of the oxime HI6 in dogsArchives of Toxicology, 59
Z Binenfeld, V Deljac, B Kamenar (1984)
Structure activity relationship in bispyridinium monooxime antidotes against soman poisoningActa Pharm Jugosl, 34
GD Young, I Koplovitz (1995)
Acute toxicity of cyclohexylmethylphosphonofluridate (CMPF) in rhesus monkeys: serum bochemical and hematologic changesArchiv Toxicol, 69
S. Giri, W. Younker, M. Schiedt (1985)
Effects of bleomycin on 14C‐proline uptake, its incorporation into proteins and hydroxylation in collagenous proteins of hamster lung slicesJournal of Applied Toxicology, 5
J. Clement (1983)
Efficacy of Mono- and Bis-Pyridinium Oximes Versus Soman, Sarin and Tabun Poisoning in MiceToxicological Sciences, 3
D. Maxwell, K. Brecht, I. Koplovitz (1996)
Characterization and Treatment of the Toxicity of O-isobutyl S-[2-(diethylamino)ethyl]methylphosphonothioate, a Structural Isomer of VX, in Guinea PigsInternational Journal of Toxicology, 15
T. Shih, C. Whalley, J. Valdés (1991)
A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning.Toxicology letters, 55 2
G. Amitai, Y. Kloog, D. Balderman, M. Sokolovsky (1980)
The interaction of bis-pyridinium oximes with mouse brain muscarinic receptor.Biochemical pharmacology, 29 4
Jun Suzuki, Tsunesuke Kohno, Masaki Tsukagosi, Toshihiko Furuhata, Kyouhei Yamazaki (1997)
Eighteen cases exposed to sarin in Matsumoto, Japan.Internal medicine, 36 7
G. Lallement, D. Clarençon, G. Brochier, D. Baubichon, M. Galonnier, G. Blanchet, J. Mestries (1997)
Efficacy of Atropine/Pralidoxime/Diazepam or Atropine/HI-6/Prodiazepam in Primates Intoxicated by SomanPharmacology Biochemistry and Behavior, 56
P. Aas (1996)
In vitro effects of toxogonin, HI-6 and HLö-7 on the release of [3H]acetylcholine from peripheral cholinergic nerves in rat airway smooth muscle.European journal of pharmacology, 301 1-3
F Worek, H Thiermann, L Szinicz (2004)
Experimental procedures for the selection of oximes as antidotes against nerve agent poisoning
Sun Man-chi, Lin Feng-zhen, Chou Ting-Chung (1986)
Reactivation of Sarin- or Soman-phosphonylated human acetylcholinesterase by bis-pyridinium mono-oximes.Biochemical Pharmacology, 35
G. Puu, E. Artursson, G. Bucht (1986)
Reactivation of nerve agent inhibited human acetylcholinesterases by HI-6 and obidoxime.Biochemical pharmacology, 35 9
D. Jovanović (1983)
The effect of bis-pyridinium oximes on neuromuscular blockade induced by highly toxic organophosphates in rat.Archives internationales de pharmacodynamie et de therapie, 262 2
Jiří Kassa, J. Cabal (1999)
A comparison of the efficacy of acetylcholinesterase reactivators against cyclohexyl methylphosphonofluoridate (GF agent) by in vitro and in vivo methods.Pharmacology & toxicology, 84 1
J. Clement (1982)
HI-6: reactivation of central and peripheral acetylcholinesterase following inhibition by soman, sarin and tabun in vivo in the rat.Biochemical pharmacology, 31 7
M Maksimović, B Bosković, L Radović (1980)
Antidotal effects of bispyridini-um-2-monoxime carbonyl derivatives in intoxications with highly toxic organophosphorous derivativesActa Pharm Jugosl, 30
Worek F., Reiter G., Eyer P., Szinicz L. (2002)
Reactivation kinetics of acetylcholinesterase from different species inhibited by highly toxic organophosphatesArchives of Toxicology, 76
O. Wolthuis, R. Vanwersch, H. Wiel (1981)
The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man.European journal of pharmacology, 70 3
J. Kassa, J. Bajgar (1998)
Changes of acetylcholinesterase activity in various parts of brain following nontreated and treated soman poisoning in rats.Molecular and chemical neuropathology, 33 3
F. Worek, P. Eyer, L. Szinicz (1998)
Inhibition, reactivation and aging kinetics of cyclohexylmethylphosphonofluoridate-inhibited human cholinesterasesArchives of Toxicology, 72
L. Ševelová, K. Kuča, Gabriela Krejcová-Kunesová (2005)
Antidotal treatment of GF-agent intoxication in mice with bispyridinium oximes.Toxicology, 207 1
G. Cassel, P. Fosbraey (1996)
Measurement of the oxime HI-6 after peripheral administration in tandem with neurotransmitter levels in striatal dialysates: effects of soman intoxication.Journal of pharmacological and toxicological methods, 35 3
R. Busker, J. Zijlstra, H. Wiel, B. Melchers, H. Helden (1991)
Organophosphate poisoning: a method to test therapeutic effects of oxamines other than acetylcholinesterase activation in the ratToxicology, 69
D Spriggs, S DeBus, F-C Chang (2002)
Comparison of oxime eficacies in the treatment of O-isobutyl-(2diethylamino)ethyl) methylphosphonothiolate (VR)FASEB J, 16
Jiří Kassa, Jiří Bajgar (1995)
Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methyl phosphonofluoridate (GF) in ratsHuman & Experimental Toxicology, 14
F. Worek, T. Kirchner, M. Bäcker, L. Szinicz (1996)
Reactivation by various oximes of human erythrocyte acetylcholinesterase inhibited by different organophosphorus compoundsArchives of Toxicology, 70
Kamil Kuca, J. Cabal, J. Kassa (2005)
In vitro reactivation of sarin-inhibited brain acetylcholinesterase from different species by various oximesJournal of Enzyme Inhibition and Medicinal Chemistry, 20
M. Holroyde, P. Eyre (1975)
Enterohepatic haemodynamics in calves during acute systemic anaphylaxis.European journal of pharmacology, 30 1
D. Jovanović, M. Maksimović, D. Joksovic, Kovačević (1990)
Oral forms of the oxime HI-6: a study of pharmacokinetics and tolerance after administration to healthy volunteers.Veterinary and human toxicology, 32 5
O. Wolthuis, L. Kepner (1978)
Successful oxime therapy one hour after soman intoxication in the rat.European journal of pharmacology, 49 4
K. Schoene, J. Steinhanses, H. Oldiges (1976)
Protective activity of pyridinium salts against soman poisoning in vivo and in vitro.Biochemical pharmacology, 25 17
C. Olson, R. Menton, R. Riser, M. Matthews, R. Stotts, J. Romano, I. Koplovitz, B. Hackley, J. Johnson (1997)
Efficacies of Atropine/2-PAM and Atropine/HI-6 in Treating Monkeys Intoxicated with Organophosphonate Nerve AgentsInternational Journal of Toxicology, 16
B. Bokovi (1984)
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoningToxicological Sciences, 4
The traditional therapeutic treatment of organophosphate cholinesterase inhibitor (nerve agents) poisoning consists of co-treatment with an antimuscarinic (atropine) and a reactivator of inhibited acetylcholinesterase (AChE), which contains a nucleophilic oxime function. Two oximes are presently widely available for clinical use, pralidoxime and obidoxime (toxogonin), but both offer little protection against important nerve agent threats. This has highlighted the real need for the development and availability of more effective oximes for human use, a search that has been going on for up to 30 years. However, despite the demonstration of more effective and safe oximes in animal experiments, no additional oximes have been licensed for human use. HI-6, (1-[[[4(aminocarbonyl)-pyridinio]methoxy]methyl]-2(hydroxyimino)pyridinium dichloride; CAS 34433-31-3) has been studied intensively and has been proved effective in a variety of species including non-human primates and appears from clinical experience to be safe in humans. These studies have led to the fielding of HI-6 for use against nerve agents by the militaries of the Czech republic, Sweden, Canada and under certain circumstances the Organisation for the Prohibition of Chemical Weapons. Nevertheless HI-6 has not been granted a license for clinical use, must be used only under restricted guidelines and is not available for civilian use as far as is known. This article will highlight those factors relating to HI-6 that pertain to the licensing of new compounds of this type, including the mechanism of action, the clinical and pre-clinical demonstration of safety and its efficacy against a variety of nerve agents particularly in non-human primates, since no relevant human population exists. This article also contains important data on the use of HI-6 in baboons, which has not been available previously. The article also discusses the possibility of successful therapy with HI-6 against poisoning in humans relative to doses used in non-human primates and relative to its ability to reactivate inhibited human AChE.
Adverse Drug Reactions and Toxicological Reviews – Springer Journals
Published: Aug 23, 2012
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