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Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction

Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction This work reports the preparation of propranolol according to a flow process. Propranolol has been prepared paying attention to tackle the formation of the by-product tertiary amine, resulting from an additional ring opening of the starting epoxide. Remarkably, the use of catalytic amount of water resulted beneficial for the yield and purity of the desired propranolol, and to substantially reducing the amount of tertiary amine byproduct. The high concentration of the solutions allowed for a productivity of several grams/h. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Flow Chemistry Springer Journals

Development of a continuous flow synthesis of propranolol: tackling a competitive side reaction

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Publisher
Springer Journals
Copyright
Copyright © 2019 by Akadémiai Kiadó
Subject
Chemistry; Chemistry/Food Science, general; Green Chemistry; Organic Chemistry; Inorganic Chemistry; Nanochemistry; Industrial Chemistry/Chemical Engineering
ISSN
2062-249X
eISSN
2063-0212
DOI
10.1007/s41981-019-00047-8
Publisher site
See Article on Publisher Site

Abstract

This work reports the preparation of propranolol according to a flow process. Propranolol has been prepared paying attention to tackle the formation of the by-product tertiary amine, resulting from an additional ring opening of the starting epoxide. Remarkably, the use of catalytic amount of water resulted beneficial for the yield and purity of the desired propranolol, and to substantially reducing the amount of tertiary amine byproduct. The high concentration of the solutions allowed for a productivity of several grams/h.

Journal

Journal of Flow ChemistrySpringer Journals

Published: Aug 14, 2019

References