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J. Fentem, Jeffrey Fry (1992)
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J. Fentem, A. Hammond, J. Fry (1991)
Maintenance of monooxygenase activities and detection of cytochrome P-450-mediated cytotoxicity in Mongolian gerbil hepatocyte cultures.Xenobiotica; the fate of foreign compounds in biological systems, 21 10
Julia Fentem, Jeffrey Fry, Norman Thomas (1992)
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(1992)
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JR Fry, MJ Garle, AH Hammond (1990)
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There are three principal pressures driving the development of in vitro toxicology: (1) the need for more efficient testing systems to cope with the large number of xenobiotics currently being developed; (2) public pressure to reduce animal experimentation; and (3) a need for a better understanding of the mechanisms of toxicity. Within this, in vitro toxicology is focused on local, systemic, and target-organ toxicity. It is becoming increasingly apparent that a step or decision-tree approach using input of a variety of experimental data (physicochemical properties, biokinetics, cytotoxicity) provides the most efficient system for predicting toxicity. Examples of the use of in vitro toxicity systems for prediction of systemic toxicity and target-organ (liver) toxicity are presented.
Comparative Clinical Pathology – Springer Journals
Published: Sep 15, 2004
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