Access the full text.
Sign up today, get DeepDyve free for 14 days.
Kate Oltrogge, William Peppard, M. Saleh, K. Regner, D. Herrmann (2013)
Phenytoin Removal by Continuous Venovenous HemofiltrationAnnals of Pharmacotherapy, 47
Mariann Churchwell (2012)
Use of an In Vitro Model of Renal Replacement Therapy Systems to Estimate Extracorporeal Drug RemovalThe Journal of Clinical Pharmacology, 52
Shamir Kalaria, Michael Armahizer, P. McCarthy, N. Badjatia, J. Gobburu, M. Gopalakrishnan (2020)
A Practice‐Based, Clinical Pharmacokinetic Study to Inform Levetiracetam Dosing in Critically Ill Patients Undergoing Continuous Venovenous Hemofiltration (PADRE‐01)Clinical and Translational Science, 13
Shamir Kalaria, E. Dahmane, Michael Armahizer, P. McCarthy, M. Gopalakrishnan (2018)
Development and validation of a HPLC-UV assay for quantification of levetiracetam concentrations in critically ill patients undergoing continuous renal replacement therapy.Biomedical chromatography : BMC, 32 8
Jie Shen, D. Burgess (2015)
In vitro-in vivo correlation for complex non-oral drug products: Where do we stand?Journal of controlled release : official journal of the Controlled Release Society, 219
Daiva Parakininkas, L. Greenbaum (2004)
Comparison of solute clearance in three modes of continuous renal replacement therapyPediatric Critical Care Medicine, 5
Shamir Kalaria, Michael Armahizer, P. McCarthy, N. Badjatia, J. Gobburu, M. Gopalakrishnan (2021)
A prospective, real‐world, clinical pharmacokinetic study to inform lacosamide dosing in critically ill patients undergoing continuous venovenous haemofiltration (PADRE‐02)British Journal of Clinical Pharmacology, 87
M. Hulko, U. Haug, J. Gauss, A. Boschetti-de-Fierro, W. Beck, B. Krause (2018)
Requirements and Pitfalls of Dialyzer Sieving Coefficients ComparisonsArtificial Organs, 42
(2010)
of Health and Human Services Food and Drug Administration, & Center for Drug Evaluation and Research
T. Nolin, G. Aronoff, W. Fissell, L. Jain, R. Madabushi, K. Reynolds, Lei Zhang, Shiew-Mei Huang, R. Mehrotra, M. Flessner, J. Leypoldt, J. Witcher, I. Zineh, P. Archdeacon, P. Roy-Chaudhury, S. Goldstein (2015)
Pharmacokinetic assessment in patients receiving continuous RRT: perspectives from the Kidney Health Initiative.Clinical journal of the American Society of Nephrology : CJASN, 10 1
Ludovic Aymon, S. Kissling, J. Revelly, Y. Que, A. Schneider (2013)
[Continuous renal replacement therapy for acute kidney injury].Revue medicale suisse, 9 410
Jacob Kesner, J. Yardman-Frank, R. Mercier, Craig Wong, S. Walker, Dean Argyres, A. Vilay (2014)
Trimethoprim and Sulfamethoxazole Transmembrane Clearance during Modeled Continuous Renal Replacement TherapyBlood Purification, 38
M Biagi, D Butler, X Tan, S Qasimeh, K Tejani, S Patel (2019)
Pharmackinetics and dialytic clearance of isavuconazole during in vitro and in vivo continuous renal replacement therapyAntrimicrob Agents Chemother
Mariann Churchwell, D. Pasko, B. Mueller (2006)
Daptomycin Clearance during Modeled Continuous Renal Replacement TherapyBlood Purification, 24
Sudhakar Relton, Arthur Greenberc, P. Palevsky (1992)
Dialysate and blood flow dependence of diffusive solute clearance during CVVHD.ASAIO journal, 38 3
S. Brunet, M. Leblanc, D. Geadah, Daniel Parent, S. Courteau, J. Cardinal (1999)
Diffusive and convective solute clearances during continuous renal replacement therapy at various dialysate and ultrafiltration flow rates.American journal of kidney diseases : the official journal of the National Kidney Foundation, 34 3
M. Sigler, B. Teehan (1987)
Solute transport in continuous hemodialysis: a new treatment for acute renal failure.Kidney international, 32 4
Sherri Smith, N. Waters (2018)
Pharmacokinetic and Pharmacodynamic Considerations for Drugs Binding to Alpha-1-Acid GlycoproteinPharmaceutical Research, 36
S. Jang, Grayson Hough, B. Mueller (2018)
Ex vivo Rezafungin Adsorption and Clearance During Continuous Renal Replacement TherapyBlood Purification, 46
D. Pasko, Mariann Churchwell, N. Salama, B. Mueller (2011)
Longitudinal Hemodiafilter Performance in Modeled Continuous Renal Replacement TherapyBlood Purification, 32
J. Stevenson, Jignesh Patel, Mariann Churchwell, A. Vilay, D. Depestel, F. Sörgel, M. Kinzig, V. Jakob, B. Mueller (2008)
Ertapenem clearance during modeled continuous renal replacement therapyThe International Journal of Artificial Organs, 31
(2021)
OUP accepted manuscriptJournal of Antimicrobial Chemotherapy
S. Goldstein, T. Nolin (2014)
Lack of Drug Dosing Guidelines for Critically Ill Patients Receiving Continuous Renal Replacement TherapyClinical Pharmacology & Therapeutics, 96
J. Schefold, S. Haehling, R. Pschowski, T. Bender, Cathrin Berkmann, Sophie Briegel, D. Hasper, A. Jörres (2014)
The effect of continuous versus intermittent renal replacement therapy on the outcome of critically ill patients with acute renal failure (CONVINT): a prospective randomized controlled trialCritical Care, 18
J. Augustine, D. Sandy, T. Seifert, E. Paganini (2004)
A randomized controlled trial comparing intermittent with continuous dialysis in patients with ARF.American journal of kidney diseases : the official journal of the National Kidney Foundation, 44 6
S. Lewis, L. Switaj, B. Mueller (2015)
Tedizolid Adsorption and Transmembrane Clearance during in vitro Continuous Renal Replacement TherapyBlood Purification, 40
P. Purohit, M. Elkomy, A. Frymoyer, S. Sutherland, D. Drover, G. Hammer, F. Su (2019)
Antimicrobial Disposition During Pediatric Continuous Renal Replacement Therapy Using an Ex Vivo Model.Critical Care Medicine
Kathryn Chappell, Lauren Kimmons, J. Haller, R. Canada, Hui-jiao He, J. Hudson (2020)
Levetiracetam pharmacokinetics in critically ill patients undergoing renal replacement therapy.Journal of critical care, 61
S. Tandukar, P. Palevsky (2019)
Continuous Renal Replacement Therapy: Who, When, Why, and HowChest, 155
R. Mehta, B. Mcdonald, F. Gabbai, M. Pahl, M. Pascual, A. Farkas, Robert Kaplan (2001)
A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure.Kidney international, 60 3
J. Nicholson, M. Wolmarans, G. Park (2000)
The role of albumin in critical illness.British journal of anaesthesia, 85 4
A Tolwani (2012)
2505N Engl J Med, 367
A. Isla, A. Gascón, J. Maynar, A. Arzuaga, D. Toral, J. Pedraz (2005)
Cefepime and continuous renal replacement therapy (CRRT): in vitro permeability of two CRRT membranes and pharmacokinetics in four critically ill patients.Clinical therapeutics, 27 5
Alain Bonnardeaux, Vincent Pichette, D. Ouimet, D. Geadah, Francine Habel, Jean-François Cardinal (1992)
Solute clearances with high dialysate flow rates and glucose absorption from the dialysate in continuous arteriovenous hemodialysis.American journal of kidney diseases : the official journal of the National Kidney Foundation, 19 1
Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
C. Vinsonneau, C. Camus, A. Combes, Marie Beauregard, K. Klouche, T. Boulain, J. Pallot, J. Chiche, P. Taupin, P. Landais, J. Dhainaut (2006)
Continuous venovenous haemodiafiltration versus intermittent haemodialysis for acute renal failure in patients with multiple-organ dysfunction syndrome: a multicentre randomised trialThe Lancet, 368
T. Golper, Michael Marx (1998)
Drug dosing adjustments during continuous renal replacement therapies.Kidney international. Supplement, 66
ObjectivesResults from previous ex-vivo continuous renal replacement therapy (CRRT) models have successfully demonstrated similar extraction coefficients (EC) identified from in-vivo clinical trials. The objectives of this study are to develop an ex-vivoin-vivo correlation (EVIVC) model to predict drug clearance for commonly used antiepileptics and to evaluate similarity in drug extraction across different CRRT modalities to extrapolate dosing recommendations.MethodsLevetiracetam, lacosamide, and phenytoin CRRT clearance was evaluated using the Prismaflex CRRT system and M150 hemodiafilters using an albumin containing normal saline (ALB-NS) vehicle with 3 different albumin concentrations (2 g/dL, 3 g/dL, and 4 g/dL) and a human plasma vehicle at 3 different effluent flow rates (1 L/hr, 2 L/hr, and 3 L/hr). Blood and effluent/dialysate concentrations were collected after circuit priming. ECs were calculated for each drug, modality, vehicle, and experimental arm combination.ResultsThe calculated average EC for levetiracetam and lacosamide was approximated to the fraction unbound from plasma protein. Human plasma and ALB-NS vehicles demonstrated adequate prediction of in-vivo CRRT clearance. Geometric mean ratios indicated similarity in extraction coefficients when comparing between hemofiltration and hemodiafiltration modalities and between filtration and dialysis modalities at effluent flow rates ≤ 2L/hr. Evaluation of phenytoin provided inconsistent findings with regards to extraction coefficient similarity across different CRRT modalities.ConclusionThe findings indicate that an ex-vivo study can be used as a surrogate to predict in-vivo levetiracetam and lacosamide clearance in patients receiving CRRT.
Pharmaceutical Research – Springer Journals
Published: May 1, 2022
Keywords: antiepileptics; continuous renal replacement therapy; critical care; ivivc correlation; nephrology
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.