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Deuterium labeling of glyprolines by isotope exchange

Deuterium labeling of glyprolines by isotope exchange Deuterium-labeled 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-Pro-NH2, and Phe-Pro-LeuPro-Ala were synthesized. The effect of the method of peptide deposition on the catalyst, the catalyst nature, temperature, and structure of peptides on the inclusion of deuterium with the formation of the appropriate number of isotopomers was demonstrated. The 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-Pro-NH2, and Phe-Pro-Leu-Pro-Ala peptides containing, on average, 4.6, 7.7, and 5.4 deuterium atoms per peptide molecule, respectively, were obtained. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Doklady Chemistry Springer Journals

Deuterium labeling of glyprolines by isotope exchange

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References (5)

Publisher
Springer Journals
Copyright
Copyright © 2016 by Pleiades Publishing, Ltd.
Subject
Chemistry; Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering
ISSN
0012-5008
eISSN
1608-3113
DOI
10.1134/S0012500816020087
Publisher site
See Article on Publisher Site

Abstract

Deuterium-labeled 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-Pro-NH2, and Phe-Pro-LeuPro-Ala were synthesized. The effect of the method of peptide deposition on the catalyst, the catalyst nature, temperature, and structure of peptides on the inclusion of deuterium with the formation of the appropriate number of isotopomers was demonstrated. The 5-oxo-Pro-Arg-Pro, 5-oxo-Pro-His-Pro-Gly-Pro-NH2, and Phe-Pro-Leu-Pro-Ala peptides containing, on average, 4.6, 7.7, and 5.4 deuterium atoms per peptide molecule, respectively, were obtained.

Journal

Doklady Chemistry – Springer Journals

Published: Apr 1, 2016

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