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- Publisher
- Springer Journals
- Copyright
- Copyright © The Author(s), under exclusive licence to Korean Society of Nuclear Medicine 2022
- ISSN
- 1869-3474
- eISSN
- 1869-3482
- DOI
- 10.1007/s13139-022-00736-8
- Publisher site
- See Article on Publisher Site
Abstract
Accurate determination of the hormone receptor status in patients with breast cancer is necessary to provide better palliative treatment because of the frequent discordant status of hormone receptors between primary breast cancer and metastatic lesions. In particular, the invasive nature and small number of cells recovered from the cerebrospinal fluid collected through lumbar puncture limit the detailed immunocytochemistry investigation of leptomeningeal metastasis. Moreover, none of the conventional imaging modalities provide any information on the hormone receptor status of leptomeningeal metastasis in patients with breast cancer. Herein, we report estrogen receptor–positive leptomeningeal metastasis clearly demonstrated by 16α-[18F]-fluoro-17β-estradiol ([18F]-FES) positron emission tomography/computed tomography (PET/CT) in a patient with metastatic breast cancer.
Journal
Nuclear Medicine and Molecular Imaging – Springer Journals
Published: Apr 1, 2022
Keywords: Breast cancer; Leptomeningeal metastasis; 16α-[18F]-fluoro-17β-estradiol ([18F]-FES); Estrogen receptor