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- Publisher
- Springer Journals
- Copyright
- Copyright © 1993 by Springer-Verlag
- Subject
- Medicine & Public Health; Pathology; Hematology; Oncology
- eISSN
- 1433-2973
- DOI
- 10.1007/BF02341967
- Publisher site
- See Article on Publisher Site
Abstract
In autoimmune haemolytic anaemia (AHA) antibody(ies) are directed at ‘self’ red blood cells (RBC) and can effect their destruction. This removal of RBC may be enhanced by the additional presence of complement on the cell membrane. The diagnosis of AHA requires the demonstration of such antibody(ies), which are able to sensitise autologous erythrocytes in vivo. AHA has been described in a variety of animal species but the techniques employed in the laboratory diagnosis have, generally, been extrapolated from those used in human serology. The application of newer and more sensitive techniques to the assessment of RBC sensitisation with antibody and complement, has improved the diagnosis of AHA. Furthermore, it is now possible to assess the significance of the degree of RBC sensitisation and to evaluate treatment regimens.
Journal
Comparative Clinical Pathology – Springer Journals
Published: Feb 20, 2006