Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Park, Y. Cho (2007)
In vitro cellular uptake and cytotoxicity of paclitaxel-loaded glycol chitosan self-assembled nanoparticlesMacromolecular Research, 15
Jun Wu, Qing Liu, Robert Lee (2006)
A folate receptor-targeted liposomal formulation for paclitaxel.International journal of pharmaceutics, 316 1-2
E. Park, So Kim, Sang Lee, Y. Lee (2005)
Folate-conjugated methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery.Journal of controlled release : official journal of the Controlled Release Society, 109 1-3
S. Mohapatra, S. Mallick, T. Maiti, S. Ghosh, P. Pramanik (2007)
Synthesis of highly stable folic acid conjugated magnetite nanoparticles for targeting cancer cellsNanotechnology, 18
H. Maeda, T. Sawa, T. Konno (2001)
Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS.Journal of controlled release : official journal of the Controlled Release Society, 74 1-3
Kyeongsoon Park, G. Lee, Yoo-shin Kim, M. Yu, R. Park, In‐San Kim, S. Kim, Y. Byun (2006)
Heparin-deoxycholic acid chemical conjugate as an anticancer drug carrier and its antitumor activity.Journal of controlled release : official journal of the Controlled Release Society, 114 3
V. Bobek, J. Kovařík (2004)
Antitumor and antimetastatic effect of warfarin and heparins.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 58 4
S. Siragusa (2011)
Low molecular weight heparins in cancer patients: to treat thromboembolic events, the tumor, or both?Oncology Reviews, 1
So Kim, S. Cho, Y. Lee, L. Chu (2007)
Biotin-conjugated block copolymeric nanoparticles as tumor-targeted drug delivery systemsMacromolecular Research, 15
Steven Weitman, R. Lark, L. Coney, Daniel Fort, Verna Frasca, Vincent Zurawski, B. Kamen (1992)
Distribution of the folate receptor GP38 in normal and malignant cell lines and tissues.Cancer research, 52 12
T. Kōmoto, Y. Kojima, T. Kawai (1978)
Conformation of poly(β-benzyl-L-aspartate) formed during heterogeneous polymerizationMacromolecular Chemistry and Physics, 179
I. Shin, So Kim, Young Lee, C. Cho, Yong Sung (1998)
Methoxy poly(ethylene glycol)/epsilon-caprolactone amphiphilic block copolymeric micelle containing indomethacin. I. Preparation and characterization.Journal of controlled release : official journal of the Controlled Release Society, 51 1
Agnes Lee (2007)
The effects of low molecular weight heparins on venous thromboembolism and survival in patients with cancer.Thrombosis research, 120 Suppl 2
W. Daly, D. Poché (1988)
The preparation of N-carboxyanhydrides of α-amino acids using bis(trichloromethyl)carbonateTetrahedron Letters, 29
M. Wilhelm, Cheng-Le Zhao, Y. Wang, R. Xu, M. Winnik, Jean-Luc Mura, G. Riess, M. Croucher (1991)
Poly(styrene-ethylene oxide) block copolymer micelle formation in water: a fluorescence probe studyMacromolecules, 24
J. Folkman (1997)
Angiogenesis and angiogenesis inhibition: an overview.EXS, 79
R. K. Jain (2001)
10.1016/S0169-409X(00)00131-9Adv. Drug Deliv. Rev., 46
S. Shukla, Gong Wu, Madhumita Chatterjee, Weilian Yang, M. Sekido, Lamine Diop, R. Müller, J. Sudimack, Robert Lee, R. Barth, W. Tjarks (2003)
Synthesis and biological evaluation of folate receptor-targeted boronated PAMAM dendrimers as potential agents for neutron capture therapy.Bioconjugate chemistry, 14 1
R. Jain (1997)
Delivery of molecular and cellular medicine to solid tumors.Advanced drug delivery reviews, 64 Suppl
A. Cate‐Hoek, M. Prins (2008)
Low molecular weight heparins in cancer. Management and prevention of venous thromboembolism in patients with malignancies.Thrombosis research, 122 5
A. Agarwal, Surbhi Saraf, Abhay Asthana, U. Gupta, V. Gajbhiye, N. Jain (2008)
Ligand based dendritic systems for tumor targeting.International journal of pharmaceutics, 350 1-2
C. Lipinski, F. Lombardo, B. Dominy, P. Feeney (1997)
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settingsAdvanced Drug Delivery Reviews, 46
T. Niers, C. Klerk, M. Dinisio, C. Noorden, H. Büller, P. Reitsma, D. Richel (2007)
Mechanisms of heparin induced anti-cancer activity in experimental cancer models.Critical reviews in oncology/hematology, 61 3
K. Huh, Sang Lee, Y. Cho, Jaehwi Lee, J. Jeong, Kinam Park (2005)
Hydrotropic polymer micelle system for delivery of paclitaxel.Journal of controlled release : official journal of the Controlled Release Society, 101 1-3
P. Thorpe, E. Derbyshire, S. Andrade, N. Press, P. Knowles, S. King, G. Watson, Yuh Yang, M. Rao-Betté (1993)
Heparin-steroid conjugates: new angiogenesis inhibitors with antitumor activity in mice.Cancer research, 53 13
R. Linhardt (2003)
2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity.Journal of medicinal chemistry, 46 13
Tim Meyer, I. Hart (1998)
Mechanisms of tumour metastasis.European journal of cancer, 34 2
I. Astafieva, X. Zhong, A. Eisenberg (1993)
Critical micellization phenomena in block polyelectrolyte solutionsMacromolecules, 26
G. Molema (2005)
Design of vascular endothelium-specific drug-targeting strategies for the treatment of cancer.Acta biochimica Polonica, 52 2
F. Wolf, G. Brett (2000)
Ligand-binding proteins: their potential for application in systems for controlled delivery and uptake of ligands.Pharmacological reviews, 52 2
Robert Lee, Philip Low (1994)
Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.The Journal of biological chemistry, 269 5
I. Campbell, T. Jones, W. Foulkes, J. Trowsdale (1991)
Folate-binding protein is a marker for ovarian cancer.Cancer research, 51 19
N. Rapoport (2007)
Physical stimuli-responsive polymeric micelles for anti-cancer drug deliveryProgress in Polymer Science, 32
So Kim, I. Shin, Y. Lee, C. Cho, Y. Sung (1998)
METHOXY POLY(ETHYLENE GLYCOL) AND CAPROLACTONE AMPHIPHILIC BLOCK CO POLYMERIC MICELLE CONTAINING INDOMETHACIN. II: MICELLE FORMATION AND DRUG RELEASE BEHAVIORSJournal of Controlled Release, 51
G. Lee, S. Kim, Y. Byun (2007)
Glucosylated heparin derivatives as non-toxic anti-cancer drugs.Journal of controlled release : official journal of the Controlled Release Society, 123 1
J. Kukowska-Latallo, Kimberly Candido, Zhengyi Cao, Shraddha Nigavekar, I. Majoros, Thommey Thomas, L. Balogh, Mohamed Khan, J. Baker (2005)
Nanoparticle targeting of anticancer drug improves therapeutic response in animal model of human epithelial cancer.Cancer research, 65 12
Eun Lee, K. Na, Y. Bae (2003)
Polymeric micelle for tumor pH and folate-mediated targeting.Journal of controlled release : official journal of the Controlled Release Society, 91 1-2
C. Allen, D. Maysinger, A. Eisenberg (1999)
Nano-engineering block copolymer aggregates for drug deliveryColloids and Surfaces B: Biointerfaces, 16
P. Smith, A. Mallia, G. Hermanson (1980)
Colorimetric method for the assay of heparin content in immobilized heparin preparations.Analytical biochemistry, 109 2
Kyeongsoon Park, Kwangmeyung Kim, I. Kwon, S. Kim, Seulki Lee, Dong Lee, Y. Byun (2004)
Preparation and characterization of self-assembled nanoparticles of heparin-deoxycholic acid conjugates.Langmuir : the ACS journal of surfaces and colloids, 20 26
M. Yu, Dong Lee, Yoo-shin Kim, Kyeongsoon Park, Soo-Ah Park, D. Son, G. Lee, J. Nam, S. Kim, In‐San Kim, R. Park, Y. Byun (2007)
Antiangiogenic and Apoptotic Properties of a Novel Amphiphilic Folate-Heparin-Lithocholate Derivative Having Cellular Internality for Cancer TherapyPharmaceutical Research, 24
Su-yao Xiao, C. Tong, Xuanming Liu, D. Yu, Qiaoling Liu, Changgang Xue, Dong-Ying Tang, Lijian Zhao (2006)
Preparation of folate-conjugated starch nanoparticles and its application to tumor-targeted drug delivery vectorChinese Science Bulletin, 51
S. Smorenburg, C. Noorden (2001)
The complex effects of heparins on cancer progression and metastasis in experimental studies.Pharmacological reviews, 53 1
Abstract A ligand-mediated nanoparticulate drug carrier composed of heparin-based copolymers was designed to achieve targeted drug delivery for chemotherapy. Novel amphiphilic copolymers composed of heparin with antitumor activities and poly(β-benzyl-L-aspartate) (PBLA) with the potential capacity for serving as pH-responsive drug release reservoirs were synthesized by conjugating PBLA as a hydrophobic segment to the hydrophilic heparin backbone. To introduce folate ligands for tumor targeting to the heparin/PBLA copolymers, folate-conjugated heparin/PBLA copolymers were prepared with various compositions by varying the feed molar ratio of PBLA, amineterminated folate (or folate-conjugated PEG) to heparin. The synthesis and composition of the heparin-based copolymers were confirmed by 1H NMR and colorimetric methods, respectively. Heparin-based amphiphilic copolymeric nanoparticles were prepared by micelle formation in an aqueous solution. The properties of the micelles were described by the critical micelle concentration (CMC), size and size distribution. The CMC values of heparin-based copolymers decreased with increasing concentration of the PBLA hydrophobic segments in the copolymers. The conjugation of folate (or folate-conjugated PEG) with hydrophilic nature into heparin/PBLA copolymers affected the free chain-micelle equilibrium, leading to an increase in the CMC values. The particle size of the heparin-based copolymers determined by light scattering measurements ranged from 100 to 130 nm, depending on the molecular weight and composition of the copolymers. Field emission scanning electron microscopy showed that the heparinbased copolymeric particles had a sub-micron size with spherical shape.
"Macromolecular Research" – Springer Journals
Published: Feb 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.