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Dennettia tripetala preserves hepatic and renal tissue structure and function

Dennettia tripetala preserves hepatic and renal tissue structure and function Although a single administration of carbon tetrachloride (CCl4) can injure the liver and kidneys of rats, repeated exposures can cause more severe damage. This study was therefore designed to test the ability of Dennettia tripetala (D. tripetala) to prevent severe liver and kidney damage, caused by repeated exposures to CCl4. Rats were force-fed daily with D. tripetala extracts for 21 days, and from day 18 to 21, CCl4 was additionally administered. Positive and negative controls were included. At the end of the experiment, the animals were sacrificed and subjected to biochemical and histopathological examinations. CCl4 caused elevations in serum activities of liver enzymes, as well as total protein and globulin concentration, while the albumin concentration dropped drastically. In the liver, the concentration of lipids increased, with a concomitant decrease in the blood. The concentration of urea and creatinine in the blood also increased, the activity of antioxidant enzymes in the liver and kidneys dropped, and the concentration of malondialdehyde in these organs increased significantly. There were also histopathological changes in the liver and kidneys, and D. tripetala significantly prevented these hepatorenal injuries. Taken together, the results show that D. tripetala can prevent the liver and kidneys from severe damage triggered by repeated exposures to CCl4. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Dennettia tripetala preserves hepatic and renal tissue structure and function

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References (34)

Publisher
Springer Journals
Copyright
Copyright © The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2021
eISSN
1618-565X
DOI
10.1007/s00580-021-03304-2
Publisher site
See Article on Publisher Site

Abstract

Although a single administration of carbon tetrachloride (CCl4) can injure the liver and kidneys of rats, repeated exposures can cause more severe damage. This study was therefore designed to test the ability of Dennettia tripetala (D. tripetala) to prevent severe liver and kidney damage, caused by repeated exposures to CCl4. Rats were force-fed daily with D. tripetala extracts for 21 days, and from day 18 to 21, CCl4 was additionally administered. Positive and negative controls were included. At the end of the experiment, the animals were sacrificed and subjected to biochemical and histopathological examinations. CCl4 caused elevations in serum activities of liver enzymes, as well as total protein and globulin concentration, while the albumin concentration dropped drastically. In the liver, the concentration of lipids increased, with a concomitant decrease in the blood. The concentration of urea and creatinine in the blood also increased, the activity of antioxidant enzymes in the liver and kidneys dropped, and the concentration of malondialdehyde in these organs increased significantly. There were also histopathological changes in the liver and kidneys, and D. tripetala significantly prevented these hepatorenal injuries. Taken together, the results show that D. tripetala can prevent the liver and kidneys from severe damage triggered by repeated exposures to CCl4.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Feb 1, 2022

Keywords: Dennettia tripetala; Antioxidants; Carbon tetrachloride; Steatosis; Liver; Kidney

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