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Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
- Publisher
- Springer Journals
- Copyright
- Copyright © Sociedade Brasileira de Engenharia Biomedica 2022
- ISSN
- 2446-4732
- eISSN
- 2446-4740
- DOI
- 10.1007/s42600-022-00224-0
- Publisher site
- See Article on Publisher Site
Abstract
The effects of dalcetrapib (dal) and reduced glutathione (GSH) on a hemoglobin S (HbS) polymerization process are quantitatively evaluated using proton (1H) magnetic relaxation. The HbS samples were obtained, using classical methods (centrifuging, decanting, and freezing–thawing cycles), starting from whole blood of voluntary patients suffering sickle cell disease (SCD). The transversal 1H magnetic relaxation time (T2) was determined at 36 °C using the Carr-Purcell-Meiboom-Gill (CPMG) experiment (echo time: 1000 μs, 1000 echoes, 90° and 180° pulses of equal amplitude, and with 5 μs and 10 μs of width respectively), and its temporal behavior was used to obtain the initial (T2i) and final (T2f) values of T2 as well as the delay time (td) of the HbS polymerization process. Both compounds showed an effect on the HbS polymerization process with increments of td in the 60% of the samples treated with GSH, as well as an increase of T2i and T2f in the 100% of the samples treated with dal. The changes in these parameters indicate, in both cases, an inhibition of the HbS polymerization processes.
Journal
Research on Biomedical Engineering – Springer Journals
Published: Sep 1, 2022
Keywords: HbS Polymerization; T2; Dalcetrapib; Reduced glutathione