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M. Aronsohn, J. Carpenter (1990)
Distal extremity melanocytic nevi and malignant melanomas in dogs.Journal of The American Animal Hospital Association, 26
R. Ayl, C. Couto, A. Hammer, S. Weisbrode, J. Ericson, L. Mathes (1992)
Correlation of DNA Ploidy to Tumor Histologic Grade, Clinical Variables, and Survival in Dogs with Mast Cell TumorsVeterinary Pathology, 29
J. Peterson (2006)
Tumors of the Skin and Subcutaneous Tissues
M. Friedlander, D. Hedley, I. Taylor (1984)
Clinical and biological significance of aneuploidy in human tumours.Journal of Clinical Pathology, 37
Sionagh Smith, M. Goldschmidt, P. McManus (2002)
A Comparative Review of Melanocytic NeoplasmsVeterinary Pathology, 39
Michael Fox, Leslie Armstrong, S. Withrow, Barbara Powers, Susan LaRue, R. Straw, E. Gillette (1990)
Comparison of DNA aneuploidy of primary and metastatic spontaneous canine osteosarcomas.Cancer research, 50 19
D. Ruiter (1992)
Clinical and pathologic diagnosis, staging and prognostic factors of melanoma, and management of primary diseaseCurrent Opinion in Oncology, 4
B. Davis (1994)
Flow cytometry and clinical diagnosisHuman Pathology, 25
D. Vail, S. Withrow (2007)
Chapter 18 – Tumors of the Skin and Subcutaneous Tissues
I. Ahmed (1997)
Malignant melanoma: prognostic indicators.Mayo Clinic proceedings, 72 4
M. Ritt, J. Wojcieszyn, J. Modiano (1998)
Functional Loss of p21/Waf-1 in a Case of Benign Canine Multicentric MelanomaVeterinary Pathology, 35
D. Marino, Matthiesen Dt, Stefanacci Jd, Moroff Sd (1995)
Evaluation of dogs with digit masses: 117 cases (1981-1991).Journal of the American Veterinary Medical Association, 207 6
E. Cotchin (1955)
Melanotic tumours of dogs.Journal of comparative pathology, 65 2
R. Diters, R. Dubelzig, G. Aguirre, G. Acland (1983)
Primary Ocular Melanoma in DogsVeterinary Pathology, 20
J. Ramos-Vara, M. Beissenherz, Margaret Miller, G. Johnson, L. Pace, A. Fard, S. Kottler (2000)
Retrospective Study of 338 Canine Oral Melanomas with Clinical, Histologic, and Immunohistochemical Review of 129 CasesVeterinary Pathology, 37
R. Todoroff, R. Brodey (1979)
Oral and pharyngeal neoplasia in the dog: a retrospective survey of 361 cases.Journal of the American Veterinary Medical Association, 175 6
K. Culmsee, I. Nolte (2002)
Flow cytometry and its application in small animal oncology.Methods in cell science : an official journal of the Society for In Vitro Biology, 24 1-3
E. Hellmén, S. Svensson (1995)
Progression of canine mammary tumours as reflected by DNA ploidy in primary tumours and their metastases.Journal of comparative pathology, 113 4
D. Weinberg (1994)
Flow Cytometry and Clinical DiagnosisAmerican Journal of Clinical Pathology, 102
F. Clemo, D. Denicola, W. Carlton, W. Morrison, E. Walker (1994)
Flow Cytometric DNA Ploidy Analysis in Canine Transitional Cell Carcinoma of Urinary BladdersVeterinary Pathology, 31
Erik Teske, G. Rutteman, N. Kuipers-Dijkshoorn, J. Dierendonck, P. Heerde, C. Cornelisse (1993)
DNA ploidy and cell kinetic characteristics in canine non-Hodgkin's lymphoma.Experimental hematology, 21 4
K. Frazier, M. Hines, A. Hurvitz, P. Robinson, A. Herron (1993)
Analysis of DNA Aneuploidy and c-myc Oncoprotein Content of Canine Plasma Cell Tumors Using Flow CytometryVeterinary Pathology, 30
B. Bolon, M. Mays, B. Hall (1990)
Characteristics of Canine Melanomas and Comparison of Histology and DNA Ploidy to Their Biologic BehaviorVeterinary Pathology, 27
C. Verschueren, G. Rutteman, N. Kuipers-Dijkshoorn, B. Sjollema, J. Vos, J. Dijk, C. Cornelisse (1991)
Flow-cytometric DNA ploidy analysis in primary and metastatic canine thyroid carcinomas.Anticancer research, 11 5
D. Bostock (1979)
Prognosis after Surgical Excision of Canine MelanomasVeterinary Pathology, 16
Clinical data such as location and size of tumor and histopathological diagnosis seem to be good predictors of outcome in canine melanomas. The behavior of these tumors is site-dependent. The aim of this study was to determine whether DNA content, parameters of cell cycle kinetics, and mitotic activity correlate with location and pathological diagnosis. In 65 melanomas from archival material, the DNA content was quantified by means of flow cytometry. Six samples, in which the coefficient of variation (CV) of the G0/G1 half peak was > 6%, were excluded. DNA aneuploid tumor cells were found in 33.9%. All cutaneous melanomas, regardless of histopathological signs of malignancy, were DNA diploid and their mitotic activity was low. No significant correlations between cell cycle parameters and location of the melanomas have been proved. These results indicate that increased DNA content and percentage of G2/M phase in dog melanomas may be associated with malignant properties and with location in nail bed and in oral cavity.
Comparative Clinical Pathology – Springer Journals
Published: Aug 1, 2007
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