Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Controlled assembly of dendrimer-like DNA

Controlled assembly of dendrimer-like DNA DNA possesses many desirable chemical/physical properties as a polymeric material. With the myriad of tools available to manipulate DNA 1 , there is great potential for using DNA as a generic instead of a genetic material. Although much progress has been made in DNA computing 2,3,4 and DNA nanotechnology 5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 , the full achievement of DNA-based materials has not yet been realized. As almost all DNA molecules are either linear or circular, to rationally construct DNA materials one must first create additional shapes of DNA as basic building blocks. In addition, these DNA building blocks must be readily incorporated into larger structures in a controlled manner. Here, we show the controlled assembly of dendrimer-like DNA (DL-DNA) from Y-shaped DNA (Y-DNA). The synthesis of Y-DNA and controlled assembly of DL-DNA were robust and efficient; the resulting DL-DNA was stable and almost monodisperse. The multivalent DNA dendrimers can be either isotropic or anisotropic, providing great potential to link other entities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Materials Springer Journals

Loading next page...
 
/lp/springer-journals/controlled-assembly-of-dendrimer-like-dna-ctv8BYmdff

References (29)

Publisher
Springer Journals
Copyright
Copyright © 2003 by Nature Publishing Group
Subject
Materials Science; Materials Science, general; Optical and Electronic Materials; Biomaterials; Nanotechnology; Condensed Matter Physics
ISSN
1476-1122
eISSN
1476-4660
DOI
10.1038/nmat1045
Publisher site
See Article on Publisher Site

Abstract

DNA possesses many desirable chemical/physical properties as a polymeric material. With the myriad of tools available to manipulate DNA 1 , there is great potential for using DNA as a generic instead of a genetic material. Although much progress has been made in DNA computing 2,3,4 and DNA nanotechnology 5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 , the full achievement of DNA-based materials has not yet been realized. As almost all DNA molecules are either linear or circular, to rationally construct DNA materials one must first create additional shapes of DNA as basic building blocks. In addition, these DNA building blocks must be readily incorporated into larger structures in a controlled manner. Here, we show the controlled assembly of dendrimer-like DNA (DL-DNA) from Y-shaped DNA (Y-DNA). The synthesis of Y-DNA and controlled assembly of DL-DNA were robust and efficient; the resulting DL-DNA was stable and almost monodisperse. The multivalent DNA dendrimers can be either isotropic or anisotropic, providing great potential to link other entities.

Journal

Nature MaterialsSpringer Journals

Published: Dec 21, 2003

There are no references for this article.