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Contribution of the vascular bone marrow niche to leukemia progression

Contribution of the vascular bone marrow niche to leukemia progression Leukemia arises from leukemic stem cells, which reside within the bone marrow occupying two different stem cells niches: the endosteal and the vascular niche. The maintenance of leukemic stem cells requires complex regulation mediated by many intrinsic and extrinsic signals provided by their niche cells. The interaction of leukemic and endothelial cells can occur either via direct contact through cell adhesion molecules such as selectins or integrins or signals can be transmitted by chemokines or cytokines of which stromal cell-derived factor 1 represents the most studied. Experimental studies provide evidence that targeting molecules involved in the interaction of leukemic and endothelial cells might represent a promising therapeutic target. Indeed, first clinical trials considering this concept are currently under investigation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png memo - Magazine of European Medical Oncology Springer Journals

Contribution of the vascular bone marrow niche to leukemia progression

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Publisher
Springer Journals
Copyright
Copyright © 2014 by Springer-Verlag Wien
Subject
Medicine & Public Health; Oncology; Medicine/Public Health, general
ISSN
1865-5041
eISSN
1865-5076
DOI
10.1007/s12254-014-0149-5
Publisher site
See Article on Publisher Site

Abstract

Leukemia arises from leukemic stem cells, which reside within the bone marrow occupying two different stem cells niches: the endosteal and the vascular niche. The maintenance of leukemic stem cells requires complex regulation mediated by many intrinsic and extrinsic signals provided by their niche cells. The interaction of leukemic and endothelial cells can occur either via direct contact through cell adhesion molecules such as selectins or integrins or signals can be transmitted by chemokines or cytokines of which stromal cell-derived factor 1 represents the most studied. Experimental studies provide evidence that targeting molecules involved in the interaction of leukemic and endothelial cells might represent a promising therapeutic target. Indeed, first clinical trials considering this concept are currently under investigation.

Journal

memo - Magazine of European Medical OncologySpringer Journals

Published: Jun 13, 2014

References