Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/continuous-nitration-of-o-dichlorobenzene-in-micropacked-bed-reactor-LFQmBDoJzP
References (39)
-
Bernhard Gutmann, David Cantillo, C. Kappe (2015)
Continuous-flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients.Angewandte Chemie, 54 23
-
Yuanhai Su, Guangwen Chen, Q. Yuan (2011)
Ideal micromixing performance in packed microchannelsChemical Engineering Science, 66
-
Yuanhai Su, Yuchao Zhao, F. Jiao, Guangwen Chen, Q. Yuan (2011)
The intensification of rapid reactions for multiphase systems in a microchannel reactor by packing microparticlesAiche Journal, 57
-
Matthew Plutschack, Bartholomäus Pieber, K. Gilmore, P. Seeberger (2017)
The Hitchhiker's Guide to Flow Chemistry ∥.Chemical reviews, 117 18
-
J. Gage, Xiaowen Guo, Jianwei Tao, Changsheng Zheng (2012)
High Output Continuous NitrationOrganic Process Research & Development, 16
-
Zhiqun Yu, Qilin Xu, Linchang Liu, Z. Wu, Jiajia Huang, Jinyi Lin, W. Su (2020)
Dinitration of o-toluic acid in continuous-flow: process optimization and kinetic studyJournal of Flow Chemistry, 10
-
Timo Keutz, David Cantillo, C. Kappe (2019)
Enhanced mixing of biphasic liquid-liquid systems for the synthesis of gem-dihalocyclopropanes using packed bed reactorsJournal of Flow Chemistry, 9
-
Yangcheng Lu, Shanshan Zhu, Kai Wang, G. Luo (2016)
Simulation of the mixing process in a straight tube with sudden changed cross-sectionChinese Journal of Chemical Engineering, 24
-
Kai Wang, Liantang Li, Pei Xie, G. Luo (2017)
Liquid–liquid microflow reaction engineeringReaction Chemistry and Engineering, 2
-
Zhiqun Yu, Pengcheng Zhou, Jiming Liu, Wenzuo Wang, Chuanming Yu, W. Su (2016)
Continuous-Flow Process for Selective Mononitration of 1-Methyl-4-(methylsulfonyl)benzeneOrganic Process Research & Development, 20
-
Mrityunjay Sharma, Roopashree Acharya, A. Kulkarni (2019)
Exploring the Steady Operation of a Continuous Pilot Plant for the Di‐Nitration ReactionChemical Engineering & Technology
-
Xingjun Yao, Yan Zhang, Lingyun Du, Junhai Liu, Jianfeng Yao (2015)
Review of the applications of microreactorsRenewable & Sustainable Energy Reviews, 47
-
(2017)
Continuous synthesis of 3,4dichloronitrobenzene -
R. Halder, A. Lawal, R. Damavarapu (2007)
Nitration of toluene in a microreactorCatalysis Today, 125
-
Jisong Zhang, C. Zhang, Guotao Liu, G. Luo (2016)
Measuring enthalpy of fast exothermal reaction with infrared thermography in a microreactorChemical Engineering Journal, 295
-
G. Olah, R. Malhotra, S. Narang (1989)
Nitration: Methods and Mechanisms -
A. Bogdan, D. McQuade, D. McQuade (2009)
A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed-bed microreactorBeilstein Journal of Organic Chemistry, 5
-
Chencan Du, Peicheng Wang, Yunpeng Hu, Jisong Zhang, G. Luo (2020)
Liquid–Liquid Mass Transfer Enhancement in Milliscale Packed BedsIndustrial & Engineering Chemistry Research, 59
-
P. Quadros, N. Oliveira, C. Baptista (2005)
Continuous adiabatic industrial benzene nitration with mixed acid at a pilot plant scaleChemical Engineering Journal, 108
-
(1980)
Aromatic Nitration -
Peng Chen, Chong Shen, Min Qiu, Jing Wu, Yingjun Bai, Yuanhai Su (2020)
Synthesis of 5-fluoro-2-nitrobenzotrifluoride in a continuous-flow millireactor with a safe and efficient protocolJournal of Flow Chemistry, 10
-
A. Kulkarni (2014)
Continuous flow nitration in miniaturized devicesBeilstein Journal of Organic Chemistry, 10
-
T. Noël, S. Kuhn, Andrew Musacchio, K. Jensen, S. Buchwald (2011)
Suzuki-Miyaura cross-coupling reactions in flow: multistep synthesis enabled by a microfluidic extraction.Angewandte Chemie, 50 26
-
Jiacheng Tu, L. Sang, Hanyun Cheng, N. Ai, Jisong Zhang (2020)
Continuous Hydrogenolysis of N-Diphenylmethyl Groups in a Micropacked-Bed ReactorOrganic Process Research & Development, 24
-
(1998)
Resparch on the conventional nitration and adiabatic nitration for o-dichlorobenzene mixed acids -
Chaoyu Zhang, Jisong Zhang, Guangsheng Luo (2020)
Kinetics determination of fast exothermic reactions with infrared thermography in a microreactorJournal of Flow Chemistry, 10
-
(1998)
4-Dichloronitrobenzene synthesis process improvement -
Lei Li, Chaoqun Yao, F. Jiao, Han Mei, Guangwen Chen (2017)
Experimental and kinetic study of the nitration of 2-ethylhexanol in capillary microreactorsChemical Engineering and Processing, 117
-
(1971)
Two phase nitration of chlorobenzene . Chem . Eng . Sci -
PR Cox (1971)
10.1016/0009-2509(71)80014-3Chem. Eng. Sci., 26
-
M. Movsisyan, E. Delbeke, Jan Berton, Claudio Battilocchio, S. Ley, C. Stevens (2016)
Taming hazardous chemistry by continuous flow technology.Chemical Society reviews, 45 18
-
L. Sang, Xudong Feng, Jiacheng Tu, Bingqi Xie, G. Luo, Jisong Zhang (2020)
Investigation of external mass transfer in micropacked bed reactorsChemical Engineering Journal, 393
-
Yuanhai Su, Yuchao Zhao, Guangwen Chen, Q. Yuan (2010)
Liquid-liquid two-phase flow and mass transfer characteristics in packed microchannelsChemical Engineering Science, 65
-
Zhenghui Wen, F. Jiao, Mei Yang, Shuainan Zhao, Feng Zhou, Guangwen Chen (2017)
Process Development and Scale-up of the Continuous Flow Nitration of TrifluoromethoxybenzeneOrganic Process Research & Development, 21
-
He is now studying for his Ph.D. under the guidance of Prof. Dr. Yangcheng Lu at the State Key Laboratory of Chemical Engineering -
Zhenghui Wen, Zhenghui Wen, Mei Yang, Shuainan Zhao, Shuainan Zhao, Feng Zhou, Feng Zhou, Guangwen Chen (2018)
Kinetics study of heterogeneous continuous-flow nitration of trifluoromethoxybenzeneReaction Chemistry and Engineering, 3
-
Jun Yue (2017)
Multiphase flow processing in microreactors combined with heterogeneous catalysis for efficient and sustainable chemical synthesisCatalysis Today
-
D. Russo, G. Tomaiuolo, R. Andreozzi, S. Guido, A. Lapkin, I. Somma (2019)
Heterogeneous benzaldehyde nitration in batch and continuous flow microreactorChemical Engineering Journal, 377
-
Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
- Publisher
- Springer Journals
- Copyright
- Copyright © Akadémiai Kiadó 2021
- ISSN
- 2062-249X
- eISSN
- 2063-0212
- DOI
- 10.1007/s41981-020-00132-3
- Publisher site
- See Article on Publisher Site
Abstract
The matching of the micro-dispersion method and the reaction kinetics is of the utmost importance for the fast and strongly exothermic nitration reaction. Taken as an example to discuss this issue, a synthesis of 3,4-dichloronitrobenzene via the nitration of o-dichlorobenzene with mixed acid of nitric acid and sulfuric acid was conducted in continuous-flow reactors in this work. Through combining the adiabatic reaction environment, the use of a micropacked-bed reactor, and introducing partial product circulation, it successfully achieved the matching of the micro-dispersion state and the reaction kinetic characteristics. The good two-phase dispersion state can be maintained throughout the micropacked-bed reactor and the reaction can be completed within 5 s with above 89% selectivity under adiabatic condition. Furthermore, the reaction activation energy was conveniently obtained by processing the temperature distribution data, providing a fundamental to realize a reliable design of the nitration reaction process with high efficiency and inherent safety.Graphical abstract[graphic not available: see fulltext]
Journal
Journal of Flow Chemistry – Springer Journals
Published: Jan 5, 2021