Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Conjugation of 3′-azido-3′-deoxythymidine with heparin

Conjugation of 3′-azido-3′-deoxythymidine with heparin ISSN 0012-5008, Doklady Chemistry, 2008, Vol. 419, Part 2, pp. 95–97. © Pleiades Publishing, Ltd., 2008. Original Russian Text © I.Yu. Ponedel’kina, V.N. Odinokov, E.A. Saitgalina, E.S. Lukina, U.M. Dzhemilev, 2008, published in Doklady Akademii Nauk, 2008, Vol. 419, No. 4, pp. 512–514. CHEMISTRY I. Yu. Ponedel’kina, V. N. Odinokov, E. A. Saitgalina, E. S. Lukina, and Corresponding Member of the RAS U. M. Dzhemilev Received October 26, 2007 DOI: 10.1134/S0012500808040046 Conjugation at the carboxy groups of heparin and of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide the 5'-hydroxy groups of azidothymidine was accom- (EDC) in aqueous solution (the concentration of hep- plished through a D,L-lysine–succinic spacer. The con- arin VI was 0.015 mmol/mL, molar ratio VI : VII : jugate is consistent with 90% conversion of heparin EDC = 1 : 25 : 4, pH 4.7–4.8, 20–25°C, 24 h). Since carboxy groups into corresponding amide groups. there is no reaction of heparin with D,L-lysine acety- 3'-Azido-3'-deoxythymidine (azidothymidine) is lated at the α-amino group under the same conditions, one of the widely used antiviral drugs from the class of we can conclude that the conjugation of heparin pro- nucleoside inhibitors of reverse transcriptase. The azi- ceeds at the α-amino group of D,L-lysine. Lysine-mod- dothymidine molecule http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Doklady Chemistry Springer Journals

Conjugation of 3′-azido-3′-deoxythymidine with heparin

Download PDF
3 pages

Loading next page...
 
/lp/springer-journals/conjugation-of-3-azido-3-deoxythymidine-with-heparin-yqKd1pD5T9

References (13)

Publisher
Springer Journals
Copyright
Copyright © 2008 by MAIK Nauka
Subject
Chemistry; Industrial Chemistry/Chemical Engineering; Chemistry/Food Science, general
ISSN
0012-5008
eISSN
1608-3113
DOI
10.1134/S0012500808040046
Publisher site
See Article on Publisher Site

Abstract

ISSN 0012-5008, Doklady Chemistry, 2008, Vol. 419, Part 2, pp. 95–97. © Pleiades Publishing, Ltd., 2008. Original Russian Text © I.Yu. Ponedel’kina, V.N. Odinokov, E.A. Saitgalina, E.S. Lukina, U.M. Dzhemilev, 2008, published in Doklady Akademii Nauk, 2008, Vol. 419, No. 4, pp. 512–514. CHEMISTRY I. Yu. Ponedel’kina, V. N. Odinokov, E. A. Saitgalina, E. S. Lukina, and Corresponding Member of the RAS U. M. Dzhemilev Received October 26, 2007 DOI: 10.1134/S0012500808040046 Conjugation at the carboxy groups of heparin and of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide the 5'-hydroxy groups of azidothymidine was accom- (EDC) in aqueous solution (the concentration of hep- plished through a D,L-lysine–succinic spacer. The con- arin VI was 0.015 mmol/mL, molar ratio VI : VII : jugate is consistent with 90% conversion of heparin EDC = 1 : 25 : 4, pH 4.7–4.8, 20–25°C, 24 h). Since carboxy groups into corresponding amide groups. there is no reaction of heparin with D,L-lysine acety- 3'-Azido-3'-deoxythymidine (azidothymidine) is lated at the α-amino group under the same conditions, one of the widely used antiviral drugs from the class of we can conclude that the conjugation of heparin pro- nucleoside inhibitors of reverse transcriptase. The azi- ceeds at the α-amino group of D,L-lysine. Lysine-mod- dothymidine molecule

Journal

Doklady Chemistry – Springer Journals

Published: May 4, 2008

There are no references for this article.