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Congenital chordoma of the skin in a lamb (first report)

Congenital chordoma of the skin in a lamb (first report) Chordoma is a rare tumor in human beings and animals that originates from mesoderm-derived notochord. Although many cases of chordoma have been reported in human, dog, cat, rat, mink, and ferret, no report has been previously described in ruminants. This case report describes the clinical and histopathological findings of a congenital chordoma located in the occipital skin area of a 6-day-old, male, Iranian fat-tailed lamb. Histopathologic examination showed non-encapsulated tumor within the deep dermis. The neoplastic tissue consisted of physaliphorous cells with a fine fibrovascular stroma. The physaliphorous cells were immunoreactive with antibodies against vimentin, pancytokeratin, and S100 protein. Therefore, chordoma was diagnosed. To the best of the authors’ knowledge, this is the first case of chordoma in ruminants in the veterinary literature. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Congenital chordoma of the skin in a lamb (first report)

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References (21)

Publisher
Springer Journals
Copyright
Copyright © 2010 by Springer-Verlag London Limited
Subject
Medicine & Public Health; Oncology; Hematology; Pathology
eISSN
1618-565X
DOI
10.1007/s00580-010-1034-1
Publisher site
See Article on Publisher Site

Abstract

Chordoma is a rare tumor in human beings and animals that originates from mesoderm-derived notochord. Although many cases of chordoma have been reported in human, dog, cat, rat, mink, and ferret, no report has been previously described in ruminants. This case report describes the clinical and histopathological findings of a congenital chordoma located in the occipital skin area of a 6-day-old, male, Iranian fat-tailed lamb. Histopathologic examination showed non-encapsulated tumor within the deep dermis. The neoplastic tissue consisted of physaliphorous cells with a fine fibrovascular stroma. The physaliphorous cells were immunoreactive with antibodies against vimentin, pancytokeratin, and S100 protein. Therefore, chordoma was diagnosed. To the best of the authors’ knowledge, this is the first case of chordoma in ruminants in the veterinary literature.

Journal

Comparative Clinical PathologySpringer Journals

Published: Jun 17, 2010

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