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P. O. Brown, D. Botstein (1999)
Exploring the new world of the genome with DNA microarraysNature Genetics, 21
Eric Lander (1999)
Array of hopeNature Genetics, 21 Suppl 1
Lucy Holt, K. Büssow, G. Walter, I. Tomlinson (2000)
By-passing selection: direct screening for antibody-antigen interactions using protein arrays.Nucleic acids research, 28 15
A. Lueking, Martin Horn, H. Eickhoff, K. Büssow, H. Lehrach, G. Walter (1999)
Protein microarrays for gene expression and antibody screening.Analytical biochemistry, 270 1
Eyal Raz, Dennis Carson, Suezanne PARKERt, Tyler Parr, Anna ABAIt, Gerald Aichinger, Stanislaw GROMKOWSKIt, Malini Singh, Denise LEWt, Michelle YANKAUCKASt, Stephen BAIRDt, Gary RHODESt (1994)
Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses.Proceedings of the National Academy of Sciences of the United States of America, 91 20
C. Roberts, B. Nelson, M. Marton, R. Stoughton, Michael Meyer, Holly Bennett, Yudong He, H. Dai, W. Walker, T. Hughes, M. Tyers, Charles Boone, S. Friend (2000)
Signaling and circuitry of multiple MAPK pathways revealed by a matrix of global gene expression profiles.Science, 287 5454
W. Blackstock, M. Weir (1999)
Proteomics: quantitative and physical mapping of cellular proteins.Trends in biotechnology, 17 3
G. MacBeath, S. Schreiber (2000)
Printing proteins as microarrays for high-throughput function determination.Science, 289 5485
D. Lockhart, E. Winzeler (2000)
Genomics, gene expression and DNA arraysNature, 405
S. Bendigs, U. Salzer, G. Lipford, H. Wagner, K. Heeg (1999)
CpG‐oligodeoxynucleotides co‐stimulate primary T cells in the absence of antigen‐presenting cellsEuropean Journal of Immunology, 29
P. Arenkov, A. Kukhtin, A. Gemmell, S. Voloshchuk, V. Chupeeva, A. Mirzabekov, A. Mirzabekov (2000)
Protein microchips: use for immunoassay and enzymatic reactions.Analytical biochemistry, 278 2
Ash Alizadeh, M. Eisen, R. Davis, Chishieva Ma, I. Lossos, A. Rosenwald, Jennifer Boldrick, H. Sabet, T. Tran, Xin Yu, J. Powell, Liming Yang, G. Marti, T. Moore, J. Hudson, Li-Sheng Lu, D. Lewis, R. Tibshirani, G. Sherlock, W. Chan, T. Greiner, D. Weisenburger, J. Armitage, R. Warnke, R. Levy, W. Wilson, M. Grever, J. Byrd, D. Botstein, Pat Brown, L. Staudt (2000)
Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingNature, 403
Todd Golub, Todd Golub, D. Slonim, Pablo Tamayo, Christine Huard, Michelle Gaasenbeek, J. Mesirov, Hilary Coller, M. Loh, James Downing, Michael Caligiuri, C. Bloomfield, Eric Lander (1999)
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.Science, 286 5439
J. Derisi, V. Iyer, P. Brown (1997)
Exploring the metabolic and genetic control of gene expression on a genomic scale.Science, 278 5338
S. Gurunathan, D. Klinman, R. Seder (2000)
DNA vaccines: immunology, application, and optimization*.Annual review of immunology, 18
J. Wolff, R. Malone, P. Williams, W. Chong, G. Acsadi, Á. Jáni, P. Felgner (1990)
Direct gene transfer into mouse muscle in vivo.Science, 247 4949 Pt 1
R. Wildt, C. Mundy, B. Gorick, I. Tomlinson (2000)
Antibody arrays for high-throughput screening of antibody–antigen interactionsNature Biotechnology, 18
Ognjenka Vukmirovic, S. Tilghman (2000)
Exploring genome spaceNature, 405
H. Häcker, H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. Lipford, H. Wagner (1998)
CpG‐DNA‐specific activation of antigen‐presenting cells requires stress kinase activity and is preceded by non‐specific endocytosis and endosomal maturationThe EMBO Journal, 17
A. Pandey, M. Mann (2000)
Proteomics to study genes and genomesNature, 405
M. Corr, Delphine Lee, Dennis Carson, Helen Tighe (1996)
Gene vaccination with naked plasmid DNA: mechanism of CTL primingThe Journal of Experimental Medicine, 184
J. Watkins, G. Beuerlein, H. Wu, P. McFadden, J. Pancook, W. Huse (1998)
Discovery of human antibodies to cell surface antigens by capture lift screening of phage-expressed antibody libraries.Analytical biochemistry, 256 2
K. Büssow, D. Cahill, W. Nietfeld, D. Bancroft, E. Scherzinger, H. Lehrach, G. Walter (1998)
A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.Nucleic acids research, 26 21
W. Henzel, T. Billeci, J. Stults, Susan Wong, C. Grimley, C. Watanabe (1993)
Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases.Proceedings of the National Academy of Sciences of the United States of America, 90 11
A. Krieg, Tong Wu, R. Weeratna, S. Efler, L. Love-Homan, Lin Yang, A. Yi, D. Short, H. Davis (1998)
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs.Proceedings of the National Academy of Sciences of the United States of America, 95 21
Yukio Sato, M. Roman, H. Tighe, Delphine Lee, M. Corr, M. Nguyen, G. Silverman, M. Lotz, D. Carson, E. Raz (1996)
Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene ImmunizationScience, 273
D. Klinman, A. Yi, S. Beaucage, J. Conover, A. Krieg (1996)
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.Proceedings of the National Academy of Sciences of the United States of America, 93 7
M. D. Halpern, R. J. Kurlander, D. S. Pisetsky (1996)
Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alphaCellular Immunology, 167
R. Mullinax, E. Gross, Jeff Amberg, Beverly HAYt, H. Hogrefe, Marjorie Kubitz, A. Greener, M. Alting-Mees, D. Ardourel, J. Short, J. Sorge, Bob SHOPEStt (1990)
Identification of human antibody fragment clones specific for tetanus toxoid in a bacteriophage lambda immunoexpression library.Proceedings of the National Academy of Sciences of the United States of America, 87
T. Pertmer, A. Oran, J. Moser, C. Madorin, H. Robinson (2000)
DNA Vaccines for Influenza Virus: Differential Effects of Maternal Antibody on Immune Responses to Hemagglutinin and NucleoproteinJournal of Virology, 74
J. R. Crowther (1995)
Methods in Molecular Biology
S. Gurunathan, C. Prussin, D. Sacks, R. Seder (1998)
Vaccine requirements for sustained cellular immunity to an intracellular parasitic infectionNature Medicine, 4
M. Suter, A. Lew, P. Grob, G. Adema, M. Ackermann, K. Shortman, C. Fraefel (1999)
BAC-VAC, a novel generation of (DNA) vaccines: A bacterial artificial chromosome (BAC) containing a replication-competent, packaging-defective virus genome induces protective immunity against herpes simplex virus 1.Proceedings of the National Academy of Sciences of the United States of America, 96 22
M. Fitzgerald, L. Smith (1995)
Mass spectrometry of nucleic acids: the promise of matrix-assisted laser desorption-ionization (MALDI) mass spectrometry.Annual review of biophysics and biomolecular structure, 24
M. Halpern, R. Kurlander, D. Pisetsky (1996)
Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-αCellular Immunology, 167
J. Celis, Pavel Gromov, M. Østergaard, P. Madsen, B. Honoré, Kurt Dejgaard, E. Olsen, H. Vorum, D. Kristensen, I. Gromova, A. Haunsø, Josef Damme, M. Puype, J. Vandekerckhove, Hanne Rasmussen (1996)
Human 2‐D PAGE databases for proteome analysis in health and disease: http ://biobase.dk/cgi‐bin/celisFEBS Letters, 398
C. Nicolau, A. Pape, Philippe Soriano, F. Fargette, M. Juhel (1983)
In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I.Proceedings of the National Academy of Sciences of the United States of America, 80 4
K. Stacey, M. Sweet, D. Hume (1996)
Macrophages ingest and are activated by bacterial DNA.Journal of immunology, 157 5
N. Benvenisty, L. Reshef (1986)
Direct introduction of genes into rats and expression of the genes.Proceedings of the National Academy of Sciences of the United States of America, 83 24
B. Williams, Emma Jones, Xiao Zhu, Michael Steele, R. Stephenson, L. Rohr, A. Brothman (1996)
Evidence for a tumor suppressor gene distal to BRCA1 in prostate cancer.The Journal of urology, 155 2
A. Krieg, A. Yi, S. Matson, T. Waldschmidt, G. Bishop, R. Teasdale, G. Koretzky, D. Klinman (1995)
CpG motifs in bacterial DNA trigger direct B-cell activationNature, 374
S. Meier-Ewert, E. Maler, All Ahmadl, J. Curtis, H. Lehrach (1993)
An automated approach to generating expressed sequence cataloguesNature, 361
J. Celis, M. Kruhøffer, I. Gromova, C. Frederiksen, M. Østergaard, T. Thykjaer, Pavel Gromov, Jinsheng Yu, H. Palsdottir, N. Magnusson, T. Ørntoft (2000)
Gene expression profiling: monitoring transcription and translation products using DNA microarrays and proteomicsFEBS Letters, 480
D. Tang, M. Devit, S. Johnston (1992)
Genetic immunization is a simple method for eliciting an immune responseNature, 356
W. Huse, L. Sastry, S. Iverson, Angray Kang, M. Alting-Mees, D. Burton, S. Benkovic, R. Lerner (1989)
Generation of a large combinatorial library of the immunoglobulin repertoire in phage lambda.Science, 246 4935
Ning Yang, J. Burkholder, Beth Roberts, B. Martinell, D. Mccabe (1990)
In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment.Proceedings of the National Academy of Sciences of the United States of America, 87 24
J. Ulmer, J. Donnelly, Parker Se, G. Rhodes, P. Felgner, Dwarki Vj, SH Gromkowski, R. Deck, C. DeWITT, A. Friedman (1993)
Heterologous protection against influenza by injection of DNA encoding a viral protein.Science, 259 5102
G. Winter, A. Griffiths, R. Hawkins, H. Hoogenboom (1994)
Making antibodies by phage display technology.Annual review of immunology, 12
N. Anderson, N. Anderson (1996)
Twenty years of two‐dimensional electrophoresis: Past, present and futureELECTROPHORESIS, 17
M. Barry, W. Lai, S. Johnston (1995)
Protection against mycoplasma infection using expression-library immunizationNature, 377
T. Jakob, P. Walker, A. Krieg, M. Udey, J. Vogel (1998)
Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA.Journal of immunology, 161 6
M. Wilkins (1997)
Proteome Research: New Frontiers in Functional Genomics
H. Robinson, L. Hunt, R. Webster (1993)
Protection against a lethal influenza virus challenge by immunization with a haemagglutinin-expressing plasmid DNA.Vaccine, 11 9
At the beginning of the 21st century, biology will try to address the function of a large number of new genes. From the perspective of technologies applied today to functional genomics, this task appears to be more complex than the effort invested in the sequencing of the human genome. Conceptually, a high-throughput approach permitting correlation between newly discovered genes and functional properties of their protein products has yet to be developed. To address relationships between tens of thousands of genes and their cognate proteins, novel interdisciplinary technologies need to emerge. In this paper, a new idea of immunomics is presented and an experimental strategy is outlined to circumvent some of the restrictions associated with methodologies currently in use. It is proposed that cloned segments of genomic DNA are used for genetic immunization to obtain a large collection of antibodies, and to generate microarrays of these antibodies for tracing differentially expressed cellular proteins.
Acta Biotheoretica – Springer Journals
Published: Oct 19, 2004
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