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G. Arpino, D. Generali, A. Sapino, Lucia Matro, A. Frassoldati, M. Laurentis, Paolo Pronzato, G. Mustacchi, M. Cazzaniga, S. Placido, P. Conte, M. Cappelletti, V. Zanoni, A. Antonelli, M. Martinotti, F. Puglisi, A. Berruti, A. Bottini, L. Dogliotti (2013)
Gene expression profiling in breast cancer: a clinical perspective.Breast, 22 2
L. Vassilev, B. Vu, B. Graves, D. Carvajal, F. Podlaski, Z. Filipovic, Norman Kong, U. Kammlott, C. Lukacs, C. Klein, N. Fotouhi, E. Liu (2004)
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2Science, 303
T. Sørlie, C. Perou, R. Tibshirani, T. Aas, S. Geisler, H. Johnsen, T. Hastie, M. Eisen, M. Rijn, S. Jeffrey, T. Thorsen, H. Quist, J. Matese, P. Brown, D. Botstein, P. Lønning, A. Børresen-Dale (2001)
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implicationsProceedings of the National Academy of Sciences of the United States of America, 98
P. Fong, D. Boss, T. Yap, A. Tutt, P. Wu, M. Mergui-Roelvink, Peter Mortimer, H. Swaisland, A. Lau, M. O’Connor, A. Ashworth, J. Carmichael, S. Kaye, J. Schellens, J. Bono (2009)
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.The New England journal of medicine, 361 2
J. Stender, Kyuri Kim, T. Charn, B. Komm, Ken Chang, W. Kraus, C. Benner, C. Glass, B. Katzenellenbogen (2010)
Genome-Wide Analysis of Estrogen Receptor α DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional ActivationMolecular and Cellular Biology, 30
R. Crowder, C. Phommaly, Y. Tao, J. Hoog, Jingqin Luo, C. Perou, J. Parker, Melinda Miller, D. Huntsman, Li Lin, J. Snider, S. Davies, J. Olson, M. Watson, A. Saporita, J. Weber, M. Ellis (2009)
PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer.Cancer research, 69 9
B. Leung, Anne Potter (1987)
Mode of estrogen action on cell proliferative kinetics in CAMA-1 cells. I. Effect of serum and estrogen.Cancer investigation, 5 3
C. Perou, J. Parker, A. Prat, M. Ellis, P. Bernard (2010)
Clinical implementation of the intrinsic subtypes of breast cancer.The Lancet. Oncology, 11 8
J. Harbour, Robin Luo, Angeline Santi, A. Postigo, D. Dean (1999)
Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1Cell, 98
D. Stumpel, P. Schneider, L. Seslija, H. Osaki, O. Williams, R. Pieters, R. Stam (2012)
Connectivity mapping identifies HDAC inhibitors for the treatment of t(4;11)-positive infant acute lymphoblastic leukemiaLeukemia, 26
B. Lehmann, Joshua Bauer, X. Chen, M. Sanders, A. Chakravarthy, Y. Shyr, J. Pietenpol (2011)
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.The Journal of clinical investigation, 121 7
E. Pleasance, R. Cheetham, P. Stephens, D. Mcbride, S. Humphray, C. Greenman, I. Varela, Meng‐Lay Lin, G. Ordóñez, G. Bignell, K. Ye, J. Alipaz, Markus Bauer, D. Beare, A. Butler, Richard Carter, Lina Chen, A. Cox, S. Edkins, P. Kokko-Gonzales, N. Gormley, R. Grocock, C. Haudenschild, Matthew Hims, Terena James, Mingming Jia, Z. Kingsbury, Catherine Leroy, J. Marshall, A. Menzies, L. Mudie, Z. Ning, Tom Royce, Ole Schulz-Trieglaff, Anastassia Spiridou, L. Stebbings, L. Szajkowski, J. Teague, David Williamson, L. Chin, M. Ross, Peter Campbell, D. Bentley, P. Futreal, Michael Stratton (2010)
A comprehensive catalogue of somatic mutations from a human cancer genomeNature, 463
S. Paik, S. Shak, G. Tang, Chungyeul Kim, J. Baker, M. Cronin, F. Baehner, M. Walker, D. Watson, T. Park, W. Hiller, E. Fisher, D. Wickerham, J. Bryant, N. Wolmark, Genomic Health, Redwood City, S. Francisco (2004)
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.The New England journal of medicine, 351 27
Joshua McMichael, L. Fulton, D. Dooling, Li Ding, R. Elaine, Mardis, R. Wilson, Miruna, Balasundaram, R. Carlsen, Candace Carter, Andy, M Chu, E. Chuah, Noreen Dhalla, Ranabir, Guin, Carrie Hirst, M. Hirst, R. Holt, D. Lee, Michael, Mayo, Richard Moore, A. Mungall, E. Pleasance, A. GordonRobertson, J. Schein, A. Shafiei, Payal Sipahimalani, Jared Slobodan, Yongjun Zhao, I. Birol, Steven Jones, R. Onofrio, S. Carter, S. Schumacher, B. Tabak, Bryan Hernandez, R. Beroukhim, W. Winckler, S. Gabriel, A. Prat, Grace Silva, Jerry Usary, Douglas Voet, N. Gehlenborg, Mike Lawrence, Lihua, Zou, Pei Lin, R. Jing, JuokCho, Raktim, Sinha, R. Park, Marc-Danie Nazaire, James Robinson, Helga, Thorvaldsdottir, J. Mesirov, Peter Park, L. Chin, R. Kreisberg, A. Jacobsen, Rileen Sinha, B. Reva, R. Shen, B. Taylor, Tod Casasent, A. Unruh, Joshua Stuart, Jingchun Zhu, Chris Szeto, G. Scott, C. Yau, Evan, O. Paull, Daniel Carlin, Artem Sokolov, J. Thusberg, S. Mooney, Jay Bowen, N. Ramirez, D. Aaron, Black, R. Pyatt, P. White, E. Zmuda, J. Frick, M. Tara, Lichtenberg, Robin Brookens, Myra George, Mark Gerken, A. Hollie, Harper, K. Leraas, Teresa Tabler (2013)
Comprehensive molecular portraits of human breast tumoursYearbook of Pathology and Laboratory Medicine, 2013
G. Small, Yue Shi, L. Higgins, R. Orlowski (2007)
Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance.Cancer research, 67 9
C. Perou, T. Sørlie, M. Eisen, M. Rijn, S. Jeffrey, Christian Rees, J. Pollack, D. Ross, H. Johnsen, L. Akslen, Ø. Fluge, Alexander Pergamenschikov, Cheryl Williams, Shirley Zhu, P. Lønning, A. Børresen-Dale, P. Brown, D. Botstein (2000)
Molecular portraits of human breast tumoursNature, 406
S. Dawson, O. Rueda, S. Aparicio, C. Caldas (2013)
A new genome‐driven integrated classification of breast cancer and its implicationsThe EMBO Journal, 32
Kwang Jeong, Rajas Chodankar, D. Purcell, D. Bittencourt, M. Stallcup (2012)
Gene-specific patterns of coregulator requirements by estrogen receptor-α in breast cancer cells.Molecular endocrinology, 26 6
C. Curtis, Sohrab Shah, S. Chin, G. Turashvili, O. Rueda, M. Dunning, D. Speed, A. Lynch, S. Samarajiwa, Yinyin Yuan, S. Gräf, G. Ha, Gholamreza Haffari, A. Bashashati, R. Russell, S. McKinney, A. Langerød, A. Green, E. Provenzano, G. Wishart, S. Pinder, P. Watson, F. Markowetz, L. Murphy, I. Ellis, A. Purushotham, A. Børresen-Dale, J. Brenton, S. Tavaré, C. Caldas, S. Aparicio (2012)
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroupsNature, 486
E. Liu (2008)
Functional genomics of cancer.Current opinion in genetics & development, 18 3
A. Prat, B. Adamo, M. Cheang, C. Anders, L. Carey, C. Perou (2013)
Molecular characterization of basal-like and non-basal-like triple-negative breast cancer.The oncologist, 18 2
Shunqiang Li, D. Shen, J. Shao, R. Crowder, Wenbin Liu, A. Prat, Xiaping He, Shuying Liu, J. Hoog, Charles Lu, L. Ding, O. Griffith, Christopher Miller, David Larson, R. Fulton, M. Harrison, Thomas Mooney, Joshua McMichael, Jingqin Luo, Y. Tao, R. Gonçalves, Christopher Schlosberg, J. Hiken, L. Saied, C. Sánchez, T. Giuntoli, Caroline Bumb, C. Cooper, R. Kitchens, A. Lin, C. Phommaly, S. Davies, Jin Zhang, M. Kavuri, D. McEachern, Yi Dong, Cynthia Ma, T. Pluard, M. Naughton, R. Bose, R. Suresh, R. McDowell, L. Michel, R. Aft, W. Gillanders, K. Deschryver, R. Wilson, Shaomeng Wang, G. Mills, A. González-Angulo, J. Edwards, C. Maher, C. Perou, E. Mardis, M. Ellis (2013)
Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.Cell reports, 4 6
M. Ellis, L. Ding, D. Shen, Jingqin Luo, V. Suman, J. Wallis, B. Tine, J. Hoog, Reece Goiffon, Theodore Goldstein, S. Ng, Li Lin, R. Crowder, J. Snider, K. Ballman, J. Weber, Ken Chen, D. Koboldt, C. Kandoth, W. Schierding, Joshua McMichael, Christopher Miller, Charles Lu, C. Harris, M. McLellan, M. Wendl, K. Deschryver, D. Allred, L. Esserman, G. Unzeitig, J. Margenthaler, G. Babiera, P. Marcom, J. Guenther, M. Leitch, K. Hunt, J. Olson, Y. Tao, C. Maher, L. Fulton, R. Fulton, M. Harrison, Benjamin Oberkfell, Feiyu Du, Ryan Demeter, T. Vickery, A. Elhammali, H. Piwnica-Worms, Sandra McDonald, M. Watson, D. Dooling, D. Ota, Li-Wei Chang, R. Bose, T. Ley, D. Piwnica-Worms, Joshua Stuart, R. Wilson, E. Mardis (2012)
Whole Genome Analysis Informs Breast Cancer Response to Aromatase InhibitionNature, 486
E. Mardis (2012)
Genome sequencing and cancer.Current opinion in genetics & development, 22 3
L. Vassilev (2007)
MDM2 inhibitors for cancer therapy.Trends in molecular medicine, 13 1
R. Gonçalves, Wayne Warner, Jingqin Luo, M. Ellis (2014)
New concepts in breast cancer genomics and geneticsBreast Cancer Research : BCR, 16
Weiyi Toy, Yang Shen, H. Won, B. Green, R. Sakr, Marie Will, Zhiqiang Li, K. Gala, S. Fanning, T. King, C. Hudis, David Chen, T. Taran, G. Hortobagyi, G. Greene, M. Berger, J. Baselga, S. Chandarlapaty (2013)
ESR1 ligand binding domain mutations in hormone-resistant breast cancerNature genetics, 45
A. Prat, C. Perou (2010)
Deconstructing the molecular portraits of breast cancerMolecular Oncology, 5
J. Thigpen (2012)
Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast CancerYearbook of Oncology, 2012
N. Harbeck, A. Rody (2012)
Lost in translation? Estrogen receptor status and endocrine responsiveness in breast cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 30 7
G. Bignell, C. Greenman, H. Davies, Adam Butler, S. Edkins, J. Andrews, G. Buck, Lina Chen, D. Beare, Calli Latimer, S. Widaa, Jonathon Hinton, C. Fahey, B. Fu, Sajani Swamy, G. Dalgliesh, B. Teh, P. Deloukas, Fengtang Yang, Peter Campbell, P. Futreal, Michael Stratton (2010)
Signatures of mutation and selection in the cancer genomeNature, 463
J. Parker, Michael Mullins, M. Cheang, S. Leung, D. Voduc, T. Vickery, S. Davies, C. Fauron, Xiaping He, Zhiyuan Hu, J. Quackenbush, I. Stijleman, J. Palazzo, J. Marron, A. Nobel, E. Mardis, T. Nielsen, M. Ellis, C. Perou, P. Bernard (2009)
Supervised risk predictor of breast cancer based on intrinsic subtypes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 8
S. Shangary, Shaomeng Wang (2008)
Targeting the MDM2-p53 Interaction for Cancer TherapyClinical Cancer Research, 14
D. Yardley, R. Ismail-Khan, P. Klein (2011)
Results of ENCORE 301, a randomized, phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive (ER+) breast cancer progressing on a nonsteroidal aromatase inhibitor (AI).Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29 27_suppl
S. Banerji, K. Cibulskis, C. Rangel-Escareño, K. Brown, S. Carter, A. Frederick, M. Lawrence, A. Sivachenko, C. Sougnez, L. Zou, M. Cortés, J. Fernández-López, Shouyong Peng, K. Ardlie, D. Auclair, V. Bautista-Piña, F. Duke, J. Francis, Joonil Jung, A. Maffuz-Aziz, R. Onofrio, Melissa Parkin, Nam Pho, Valeria Quintanar-Jurado, A. Ramos, R. Rebollar-Vega, S. Rodriguez-Cuevas, S. Romero-Cordoba, S. Schumacher, Nicolas Stransky, K. Thompson, L. Uribe-Figueroa, J. Baselga, R. Beroukhim, K. Polyak, D. Sgroi, A. Richardson, G. Jiménez-Sánchez, E. Lander, S. Gabriel, L. Garraway, T. Golub, J. Meléndez-Zajgla, A. Toker, G. Getz, A. Hidalgo-Miranda, M. Meyerson (2012)
Sequence analysis of mutations and translocations across breast cancer subtypesNature, 486
D. Koboldt, K. Steinberg, D. Larson, R. Wilson, E. Mardis (2013)
The Next-Generation Sequencing Revolution and Its Impact on GenomicsCell, 155
Philip Stephens, D. Mcbride, Meng‐Lay Lin, I. Varela, Erin Pleasance, Jared Simpson, L. Stebbings, Catherine Leroy, S. Edkins, L. Mudie, C. Greenman, Mingming Jia, Calli Latimer, J. Teague, K. Lau, J. Burton, Michael Quail, H. Swerdlow, C. Churcher, R. Natrajan, A. Sieuwerts, J. Martens, Daniel Silver, A. Langerød, H. Russnes, J. Foekens, J. Reis-Filho, L. Veer, Andrea Richardson, A. Børresen-Dale, Peter Campbell, P. Futreal, Michael Stratton (2009)
COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMESNature, 462
S. Shangary, Dongguang Qin, D. McEachern, Meilan Liu, Rebecca Miller, S. Qiu, Z. Nikolovska-Coleska, Ke Ding, Guoping Wang, Jianyong Chen, D. Bernard, Jian Zhang, Yipin Lu, Q. Gu, R. Shah, K. Pienta, X. Ling, Sanmao Kang, M. Guo, Yi Sun, Dajun Yang, Shaomeng Wang (2008)
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibitionProceedings of the National Academy of Sciences, 105
P. Stephens, C. Greenman, B. Fu, Fengtang Yang, G. Bignell, L. Mudie, E. Pleasance, K. Lau, D. Beare, L. Stebbings, Stuart Mclaren, Meng‐Lay Lin, D. Mcbride, I. Varela, S. Nik-Zainal, Catherine Leroy, Mingming Jia, A. Menzies, A. Butler, J. Teague, M. Quail, J. Burton, H. Swerdlow, N. Carter, L. Morsberger, C. Iacobuzio-Donahue, G. Follows, A. Green, A. Flanagan, A. Flanagan, M. Stratton, P. Futreal, P. Campbell, Peter Campbell (2011)
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer DevelopmentCell, 144
L. Ding, M. Ellis, Shunqiang Li, D. Larson, Ken Chen, J. Wallis, C. Harris, M. McLellan, R. Fulton, L. Fulton, R. Abbott, J. Hoog, D. Dooling, D. Koboldt, Heather Schmidt, Joelle Kalicki, Qunyuan Zhang, Lei Chen, Ling Lin, M. Wendl, Joshua McMichael, V. Magrini, L. Cook, S. McGrath, T. Vickery, Elizabeth Appelbaum, K. Deschryver, S. Davies, Therese Guintoli, Li Lin, R. Crowder, Y. Tao, J. Snider, Scott Smith, Adam Dukes, Gabriel Sanderson, C. Pohl, K. Delehaunty, C. Fronick, Kimberley Pape, Jerry Reed, J. Robinson, J. Hodges, W. Schierding, N. Dees, D. Shen, Devin Locke, Madeline Wiechert, James Eldred, Joshua Peck, Benjamin Oberkfell, Justin Lolofie, Feiyu Du, Amy Hawkins, M. O'Laughlin, Kelly Bernard, M. Cunningham, Glendoria Elliott, M. Mason, Dominic Thompson, J. Ivanovich, P. Goodfellow, C. Perou, G. Weinstock, R. Aft, M. Watson, T. Ley, R. Wilson, E. Mardis (2010)
Genome Remodeling in a Basal-like Breast Cancer Metastasis and XenograftNature, 464
C. Sherr, James Roberts (1999)
CDK inhibitors: positive and negative regulators of G1-phase progression.Genes & development, 13 12
D. Robinson, Yi-Mi Wu, Pankaj Vats, Fengyun Su, R. Lonigro, Xuhong Cao, Shanker Kalyana-Sundaram, Rui Wang, Yu Ning, L. Hodges, Amy Gursky, J. Siddiqui, S. Tomlins, S. Roychowdhury, K. Pienta, Scott Kim, J. Roberts, J. Rae, C. Poznak, D. Hayes, R. Chugh, L. Kunju, M. Talpaz, A. Schott, A. Chinnaiyan (2013)
Activating ESR1 mutations in hormone-resistant metastatic breast cancerNature Genetics, 45
C. Sanchez, Cynthia Ma, R. Crowder, Therese Guintoli, C. Phommaly, F. Gao, Li Lin, M. Ellis (2011)
Preclinical modeling of combined phosphatidylinositol-3-kinase inhibition with endocrine therapy for estrogen receptor-positive breast cancerBreast Cancer Research : BCR, 13
L. Chin, W. Hahn, G. Getz, M. Meyerson (2011)
Making sense of cancer genomic data.Genes & development, 25 6
S. Paik, G. Tang, S. Shak, Chungyeul Kim, J. Baker, W. Kim, M. Cronin, F. Baehner, D. Watson, J. Bryant, J. Costantino, C. Geyer, D. Wickerham, N. Wolmark (2006)
Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 23
(2010)
Clinical Cancer esearch ing , Diagnosis , Prognosis omparison of PAM 50 Intrinsic Subtyping with unohistochemistry and Clinical Prognostic Factors in oxifen-Treated Estrogen Receptor – Positive R ast Cancer
S. Kalari, G. Pfeifer (2010)
Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.Advances in genetics, 70
D. Bell, A. Berchuck, M. Birrer, J. Chien, D. Cramer, F. Dao, R. Dhir, P. Disaia, H. Gabra, Pat Glenn, A. Godwin, J. Gross, L. Hartmann, M. Huang, D. Huntsman, M. Iacocca, M. Imieliński, S. Kalloger, B. Karlan, D. Levine, G. Mills, C. Morrison, D. Mutch, Narciso Olvera, S. Orsulic, K. Park, N. Petrelli, B. Rabeno, J. Rader, B. Sikic, K. Smith-McCune, A. Sood, D. Bowtell, R. Penny, J. Testa, K. Chang, H. Dinh, J. Drummond, G. Fowler, P. Gunaratne, A. Hawes, C. Kovar, L. Lewis, M. Morgan, I. Newsham, J. Santibanez, J. Reid, L. Treviño, Y. Wu, M. Wang, D. Muzny, D. Wheeler, R. Gibbs, G. Getz, M. Lawrence, K. Cibulskis, A. Sivachenko, C. Sougnez, Douglas Voet, Jane Wilkinson, Toby Bloom, K. Ardlie, T. Fennell, J. Baldwin, S. Gabriel, E. Lander, L. Ding, R. Fulton, D. Koboldt, M. McLellan, T. Wylie, Jason Walker, M. O'Laughlin, D. Dooling, L. Fulton, R. Abbott, N. Dees, Q. Zhang, C. Kandoth, M. Wendl, W. Schierding, D. Shen, C. Harris, H. Schmidt, Joelle Kalicki, K. Delehaunty, C. Fronick, Ryan Demeter, L. Cook, J. Wallis, L. Lin, V. Magrini, J. Hodges, James Eldred, S. Smith, C. Pohl, Fabio Vandin, Benjamin Raphael, G. Weinstock, E. Mardis, R. Wilson, M. Meyerson, W. Winckler, R. Verhaak, Suzie Carter, C. Mermel, G. Saksena, H. Nguyen, R. Onofrio, D. Hubbard, S. Gupta, A. Crenshaw, A. Ramos, L. Chin, A. Protopopov, Juinhua Zhang, T. Kim, I. Perna, Y. Xiao, Hailei Zhang, G. Ren, N. Sathiamoorthy, R. Park, E. Lee, P. Park, R. Kucherlapati, D. Absher, L. Waite, G. Sherlock, J. Brooks, Jun Li, Jin Xu, R. Myers, P. Laird, L. Cope, J. Herman, Hui Shen, D. Weisenberger, H. Noushmehr, F. Pan, T. Triche, B. Berman, D. Berg, J. Buckley, S. Baylin, P. Spellman, E. Purdom, P. Neuvial, H. Bengtsson, L. Jakkula, S. Durinck, J. Han, S. Dorton, H. Marr, Y. Choi, V. Wang, Ninghai Wang, J. Ngai, J. Conboy, B. Parvin, H. Feiler, T. Speed, J. Gray, N. Socci, Yanke Liang, B. Taylor, N. Schultz, L. Borsu, A. Lash, C. Brennan, A. Viale, C. Sander, M. Ladanyi, K. Hoadley, S. Meng, Y. Du, Yufeng Shi, Lulin Li, Y. Turman, D. Zang, E. Helms, S. Balu, X. Zhou, Jinhua Wu, M. Topal, D. Hayes, C. Perou, Jun Zhang, Chaowei Wu, S. Shukla, A. Sivachenko, R. Jing, Yueh-Feng Liu, M. Noble, H. Carter, D. Kim, R. Karchin, J. Korkola, Laura Heiser, R. Cho, Zhihao Hu, E. Cerami, A. Olshen, B. Reva, Yevgeniy Antipin, R. Shen, P. Mankoo, R. Sheridan, G. Ciriello, William Chang, J. Bernanke, D. Haussler, C. Benz, Joshua Stuart, S. Benz, J. Sanborn, Charles Vaske, Jiangyu Zhu, C. Szeto, G. Scott, C. Yau, M. Wilkerson, N. Zhang, R. Akbani, K. Baggerly, W. Yung, J. Weinstein, T. Shelton, D. Grimm, M. Hatfield, S. Morris, P. Yena, P. Rhodes, M. Sherman, J. Paulauskis, S. Millis, A. Kahn, J. Greene, R. Sfeir, M. Jensen, James Chen, J. Whitmore, S. Alonso, J. Jordan, A. Chu, Jinghui Zhang, A. Barker, C. Compton, G. Eley, M. Ferguson, P. Fielding, D. Gerhard, R. Myles, C. Schaefer, K. Shaw, J. Vaught, J. Vockley, P. Good, M. Guyer, B. Ozenberger, James Peterson, E. Thomson (2011)
Integrated Genomic Analyses of Ovarian CarcinomaNature, 474
A. Berg, K. Armstrong, J. Botkin, N. Calonge, J. Haddow, Maxine Hayes, C. Kaye, K. Phillips, M. Piper, C. Richards, Joan Scott, O. Strickland, S. Teutsch (2009)
Recommendations from the EGAPP Working Group: can tumor gene expression profiling improve outcomes in patients with breast cancer?Genetics in Medicine, 11
L. Veer, H. Dai, M. Vijver, Yudong He, A. Hart, M. Mao, H. Peterse, K. Kooy, M. Marton, A. Witteveen, G. Schreiber, R. Kerkhoven, C. Roberts, P. Linsley, R. Bernards, S. Friend (2002)
Gene expression profiling predicts clinical outcome of breast cancerNature, 415
K. Albain, W. Barlow, S. Shak, G. Hortobagyi, R. Livingston, I. Yeh, P. Ravdin, R. Bugarini, F. Baehner, N. Davidson, G. Sledge, Eric Winer, C. Hudis, J. Ingle, E. Perez, K. Pritchard, L. Shepherd, J. Gralow, C. Yoshizawa, D. Allred, C. Osborne, D. Hayes (2010)
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial.The Lancet. Oncology, 11 1
R. Finn, J. Crown, I. Láng, K. Boér, I. Bondarenko, Sergey Kulyk, J. Ettl, Ravi Patel, T. Pintér, Maike Schmidt, Y. Shparyk, A. Thummala, N. Voytko, A. Breazna, Sindy Kim, S. Randolph, D. Slamon (2012)
Abstract S1-6: Results of a randomized phase 2 study of PD 0332991, a cyclin-dependent kinase (CDK) 4/6 inhibitor, in combination with letrozole vs letrozole alone for first-line treatment of ER+/HER2− advanced breast cancer (BC)Cancer Research, 72
R. Rouzier, C. Perou, W. Symmans, N. Ibrahim, M. Cristofanilli, K. Anderson, K. Hess, J. Stec, J. Stec, M. Ayers, P. Wagner, P. Morandi, Chang Fan, Islam Rabiul, J. Ross, G. Hortobagyi, L. Pusztai (2005)
Breast Cancer Molecular Subtypes Respond Differently to Preoperative ChemotherapyClinical Cancer Research, 11
B. Vogelstein, N. Papadopoulos, V. Velculescu, Shibin Zhou, L. Diaz, K. Kinzler (2013)
Cancer Genome LandscapesScience, 339
C. Sotiriou, P. Wirapati, S. Loi, AdrianL. Harris, Steve Fox, J. Smeds, H. Nordgren, P. Farmer, Viviane Praz, B. Haibe-Kains, C. Desmedt, D. Larsimont, F. Cardoso, H. Peterse, D. Nuyten, M. Buyse, M. Vijver, J. Bergh, M. Piccart, M. Delorenzi (2006)
Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis.Journal of the National Cancer Institute, 98 4
C. Sherr (1996)
Cancer Cell CyclesScience, 274
Daisuke Nakada, H. Oguro, Boaz Levi, Nicole Ryan, A. Kitano, Yusuke Saitoh, M. Takeichi, George Wendt, S. Morrison (2014)
Estrogen increases haematopoietic stem cell self-renewal in females and during pregnancyNature, 505
Yardena Samuels, Zhenghe Wang, A. Bardelli, N. Silliman, J. Ptak, Steve Szabo, Hai Yan, A. Gazdar, S. Powell, G. Riggins, J. Willson, S. Markowitz, K. Kinzler, B. Vogelstein, V. Velculescu (2004)
High Frequency of Mutations of the PIK3CA Gene in Human CancersScience, 304
M. Quail, Miriam Smith, P. Coupland, T. Otto, S. Harris, T. Connor, A. Bertoni, H. Swerdlow, Yong Gu (2012)
A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencersBMC Genomics, 13
Recent advances in molecular biology have led to unprecedented innovations in diagnosis and treatment of breast cancer. The advent of genomics has revolutionized our understanding of breast cancer. It is no longer considered a single disease but several different biologically and molecularly distinct entities. This research has led to commercially available polymerase chain reaction (PCR)-, microarray-, and next generation sequencing (NGS)-based tests which have changed the way oncologists estimate recurrence risk in early stage breast cancer patients. The genomics era has altered the clinicopathologic paradigm of selecting patients for adjuvant cytotoxic chemotherapy. Numerous well designed prospective studies are underway that may establish these molecular assays as basic elements of standard clinical practice in breast cancer diagnostics and therapeutics. In this article, we review the robustnesses and constraints of currently available breast cancer-specific molecular tests and their clinical ramifications.
Current Breast Cancer Reports – Springer Journals
Published: May 3, 2016
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