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- Publisher
- Springer Journals
- Copyright
- Copyright © 2011 by Adis Data Information BV
- Subject
- Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
- ISSN
- 1175-3277
- eISSN
- 1179-187X
- DOI
- 10.2165/11593800-000000000-00000
- pmid
- 22149319
- Publisher site
- See Article on Publisher Site
Abstract
Am J Cardiovasc Drugs 2011; 11 (6): 401-409 ORIGINAL RESEARCH ARTICLE 1175-3277/11/0006-0401/$49.95/0 ª 2011 Adis Data Information BV. All rights reserved. Comparing Antihypertensive Effect and Plasma Ciclosporin Concentration between Amlodipine and Valsartan Regimens in Hypertensive Renal Transplant Patients Receiving Ciclosporin Therapy 1 1 1 2 2 2 1 3 Jingjing Cai, Zhijun Huang, Guoping Yang, Ke Cheng, Qifa Ye, Yingzi Ming, Xiaocong Zuo, Peipei Zhou and Hong Yuan 1 Center of Clinical Pharmacology of the Third Xiangya Hospital, Central South University, Changsha, China 2 Center of Organ Transplantation of the Third Xiangya Hospital, Central South University, Changsha, China 3 Department of Cardiology, A.O. Fox Hospital, Oneonta, NY, USA Abstract Background: Hypertension, a major complication in kidney transplant recipients, is associated with pre- mature death and graft loss. However, an optimal antihypertensive therapy for these patients has not been established [Chinese Clinical Trial Registry No. ChiCTR-TRC-10001071]. Objective: The aim of the present study was to evaluate the effect of amlodipine and valsartan on BP control in renal transplant patients and to analyze the correlation between cytochrome P450 (CYP) 3A5 or multi- drug resistance-1 gene (MDR1) genotype and the antihypertensive effect of these two regimens. Methods: 150 renal transplant patients with
Journal
American Journal of Cardiovascular Drugs – Springer Journals
Published: Aug 17, 2012