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Comparative evaluation of xylazine, detomidine, and medetomidine on cardiovascular biomarkers in dromedary camels

Comparative evaluation of xylazine, detomidine, and medetomidine on cardiovascular biomarkers in... This study was performed to comparatively evaluate cardiovascular effects of xylazine, detomidine, and medetomidine after intravenous (IV) administration in dromedary camels. Ten clinically and paraclinically healthy immature male dromedary camels aged 24 ± 2 months and weighing 200 ± 20 kg were used in this study. Camels were sedated with each of three treatments in a randomized, crossover design, with a minimum washout period of 8 days between treatments. Treatments were xylazine (0.4 mg kg−1), detomidine (50 μg kg−1), and medetomidine (20 μg kg−1). Camels in the control treatment were assigned to receive normal saline. Cardiovascular biomarkers were measured at baseline (T0), 2 h (T2), and 24 h (T24) after commencing the trial. Serum concentration of cardiac troponin I (cTnI) increased from baseline in detomidine treatment at 24 h after drug administration (P < 0.05). Moreover, serum value of homocysteine (Hcy) increased from baseline in detomidine and medetomidine treatment at 24 h after drug administration (P < 0.05). Serum concentrations of lactate dehydrogenase (LDH) and creatine kinase isoenzyme MB (CK-MB) were unchanged in any treatment over 24 h. These results suggest that detomidine and medetomidine use in dromedary camels should be administered with caution, especially in camels with cardiovascular diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Clinical Pathology Springer Journals

Comparative evaluation of xylazine, detomidine, and medetomidine on cardiovascular biomarkers in dromedary camels

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Publisher
Springer Journals
Copyright
Copyright © Springer-Verlag London Ltd., part of Springer Nature 2019
Subject
Medicine & Public Health; Pathology; Hematology; Oncology
eISSN
1618-565X
DOI
10.1007/s00580-019-03056-0
Publisher site
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Abstract

This study was performed to comparatively evaluate cardiovascular effects of xylazine, detomidine, and medetomidine after intravenous (IV) administration in dromedary camels. Ten clinically and paraclinically healthy immature male dromedary camels aged 24 ± 2 months and weighing 200 ± 20 kg were used in this study. Camels were sedated with each of three treatments in a randomized, crossover design, with a minimum washout period of 8 days between treatments. Treatments were xylazine (0.4 mg kg−1), detomidine (50 μg kg−1), and medetomidine (20 μg kg−1). Camels in the control treatment were assigned to receive normal saline. Cardiovascular biomarkers were measured at baseline (T0), 2 h (T2), and 24 h (T24) after commencing the trial. Serum concentration of cardiac troponin I (cTnI) increased from baseline in detomidine treatment at 24 h after drug administration (P < 0.05). Moreover, serum value of homocysteine (Hcy) increased from baseline in detomidine and medetomidine treatment at 24 h after drug administration (P < 0.05). Serum concentrations of lactate dehydrogenase (LDH) and creatine kinase isoenzyme MB (CK-MB) were unchanged in any treatment over 24 h. These results suggest that detomidine and medetomidine use in dromedary camels should be administered with caution, especially in camels with cardiovascular diseases.

Journal

Comparative Clinical Pathology – Springer Journals

Published: Apr 23, 2020

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