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Comment on: “Predictors of Left Ventricular Dysfunction in Friedreich Ataxia in a 16-Year Observational Study”

Comment on: “Predictors of Left Ventricular Dysfunction in Friedreich Ataxia in a 16-Year... American Journal of Cardiovascular Drugs (2020) 20:509–510 https://doi.org/10.1007/s40256-020-00417-x LE T TER TO  THE   EDITOR Comment on: “Predictors of Left Ventricular Dysfunction in Friedreich Ataxia in a 16‑Year Observational Study” Roger E. Peverill Published online: 25 July 2020 © Springer Nature Switzerland AG 2020 Legrand et al. [1] report on predictors for the development also higher in males [3]. Therefore, identification of meas- of a reduced left ventricular ejection fraction (LVEF) in urements of LVEDD and SWT that have not been adjusted Friedreich ataxia (FRDA) based on 12/115 subjects who for either body size or sex as predictors of a reduced LVEF developed an LVEF ≤ 50% during 13 ± 6  years of echo- must be questionable and, at the very least, would appear cardiographic follow-up [1]. Longer length of the shorter to require an attempt at a justification in the discussion. GAA repeat expansion in the FXN gene was one predic- An additional implication of the recognized importance of tor, with > 800 categorized as high risk. Left ventricular sex effects on wall thickness for both healthy and FRDA end-diastolic diameter (LVEDD) and septal wall thick- subjects is that Henry’s nomogram (in which there is no ness (SWT) assessed 5  years prior to the diagnosis http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cardiovascular Drugs Springer Journals

Comment on: “Predictors of Left Ventricular Dysfunction in Friedreich Ataxia in a 16-Year Observational Study”

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References (3)

Publisher
Springer Journals
Copyright
Copyright © Springer Nature Switzerland AG 2020
ISSN
1175-3277
eISSN
1179-187X
DOI
10.1007/s40256-020-00417-x
Publisher site
See Article on Publisher Site

Abstract

American Journal of Cardiovascular Drugs (2020) 20:509–510 https://doi.org/10.1007/s40256-020-00417-x LE T TER TO  THE   EDITOR Comment on: “Predictors of Left Ventricular Dysfunction in Friedreich Ataxia in a 16‑Year Observational Study” Roger E. Peverill Published online: 25 July 2020 © Springer Nature Switzerland AG 2020 Legrand et al. [1] report on predictors for the development also higher in males [3]. Therefore, identification of meas- of a reduced left ventricular ejection fraction (LVEF) in urements of LVEDD and SWT that have not been adjusted Friedreich ataxia (FRDA) based on 12/115 subjects who for either body size or sex as predictors of a reduced LVEF developed an LVEF ≤ 50% during 13 ± 6  years of echo- must be questionable and, at the very least, would appear cardiographic follow-up [1]. Longer length of the shorter to require an attempt at a justification in the discussion. GAA repeat expansion in the FXN gene was one predic- An additional implication of the recognized importance of tor, with > 800 categorized as high risk. Left ventricular sex effects on wall thickness for both healthy and FRDA end-diastolic diameter (LVEDD) and septal wall thick- subjects is that Henry’s nomogram (in which there is no ness (SWT) assessed 5  years prior to the diagnosis

Journal

American Journal of Cardiovascular DrugsSpringer Journals

Published: Oct 25, 2020

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