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Clopidogrel

Clopidogrel Am J Cardiovasc Drugs 2001; 1 (6): 475-476 GUEST COMMENTARIES 1175-3277/01/0006-0475/$22.00/0 © Adis International Limited. All rights reserved. average 9-month treatment period with only a small increase in bleeding complications. A Viewpoint by David H. Fitchett Division of Cardiology, St Michael’s Hospital, University of Clopidogrel will be increasingly used in combination with as- Toronto, Onatario, Canada pirin in the early and longer-term management of patients with non-ST segment elevation acute coronary syndromes. It is indi- Platelet aggregation is central to the process that results in cated for patients with objective evidence of an acute coronary acute coronary artery occlusion in patients with acute coronary syndromes. Although aspirin, by decreasing platelet aggregation, syndrome such as ST depression >1mm, T wave inversion, or reduces recurrent coronary events by more than 50%, death, myo- elevated levels of biomarkers of myocardial necrosis such as CK- cardial infarction, and refractory myocardial ischemia remain an MB or troponin. Clopidogrel does not replace, but is complemen- important problem. Clopidogrel given orally causes irreversible tary to intravenous GP IIb/IIIa inhibitors as an early treatment in inhibition of the platelet ADP receptor and, by enhancing the high-risk patients who benefit from an early coronary angiogram anti-aggregatory effects of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Cardiovascular Drugs Springer Journals

Clopidogrel

Abstract

Am J Cardiovasc Drugs 2001; 1 (6): 475-476 GUEST COMMENTARIES 1175-3277/01/0006-0475/$22.00/0 © Adis International Limited. All rights reserved. average 9-month treatment period with only a small increase in bleeding complications. A Viewpoint by David H. Fitchett Division of Cardiology, St Michael’s Hospital, University of Clopidogrel will be increasingly used in combination with as- Toronto, Onatario, Canada pirin in the early and longer-term management of patients with non-ST...
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References (1)

Publisher
Springer Journals
Copyright
Copyright © 2001 by Adis International Limited
Subject
Medicine & Public Health; Cardiology; Pharmacotherapy; Pharmacology/Toxicology
ISSN
1175-3277
eISSN
1179-187X
DOI
10.2165/00129784-200101060-00007
Publisher site
See Article on Publisher Site

Abstract

Am J Cardiovasc Drugs 2001; 1 (6): 475-476 GUEST COMMENTARIES 1175-3277/01/0006-0475/$22.00/0 © Adis International Limited. All rights reserved. average 9-month treatment period with only a small increase in bleeding complications. A Viewpoint by David H. Fitchett Division of Cardiology, St Michael’s Hospital, University of Clopidogrel will be increasingly used in combination with as- Toronto, Onatario, Canada pirin in the early and longer-term management of patients with non-ST segment elevation acute coronary syndromes. It is indi- Platelet aggregation is central to the process that results in cated for patients with objective evidence of an acute coronary acute coronary artery occlusion in patients with acute coronary syndromes. Although aspirin, by decreasing platelet aggregation, syndrome such as ST depression >1mm, T wave inversion, or reduces recurrent coronary events by more than 50%, death, myo- elevated levels of biomarkers of myocardial necrosis such as CK- cardial infarction, and refractory myocardial ischemia remain an MB or troponin. Clopidogrel does not replace, but is complemen- important problem. Clopidogrel given orally causes irreversible tary to intravenous GP IIb/IIIa inhibitors as an early treatment in inhibition of the platelet ADP receptor and, by enhancing the high-risk patients who benefit from an early coronary angiogram anti-aggregatory effects of

Journal

American Journal of Cardiovascular DrugsSpringer Journals

Published: Aug 20, 2012

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