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Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

Clinical genetics of amyotrophic lateral sclerosis: what do we really know? Until the early 1990s, the prevailing view was that amyotrophic lateral sclerosis (ALS) was rarely familial, but subsequent genetic discoveries have overturned this idea. Andersen and Al-Chalabi document the rapidly changing genetic landscape in ALS, highlighting the lack of a clear distinction between heritable and apparently sporadic ALS, and providing recommendations for genetic counseling. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Neurology Springer Journals

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

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References (154)

Publisher
Springer Journals
Copyright
Copyright © 2011 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
Subject
Medicine & Public Health; Medicine/Public Health, general; Neurology
ISSN
1759-4758
eISSN
1759-4766
DOI
10.1038/nrneurol.2011.150
Publisher site
See Article on Publisher Site

Abstract

Until the early 1990s, the prevailing view was that amyotrophic lateral sclerosis (ALS) was rarely familial, but subsequent genetic discoveries have overturned this idea. Andersen and Al-Chalabi document the rapidly changing genetic landscape in ALS, highlighting the lack of a clear distinction between heritable and apparently sporadic ALS, and providing recommendations for genetic counseling.

Journal

Nature Reviews NeurologySpringer Journals

Published: Oct 11, 2011

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