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Enzyme activities in serum/plasma or urine are the most widely used markers of organ damage as well in human or animal clinics as in experimental toxicology. Significant interspecific differences can be observed for enzyme distribution in various species, extracellular metabolism, preanalytical and analytical conditions. Thus, to avoid any misinterpretation, all these criteria have to be documented and/or validated before use.
Comparative Clinical Pathology – Springer Journals
Published: Sep 15, 2004
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