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M. Hide, D. Francis, C. Grattan, J. Hakimi, J. Kochan, M. Greaves (1993)
Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria.The New England journal of medicine, 328 22
INVITE D COM M ENTARY Chronic Urticaria—New Concepts Regarding Pathogenesis and Treatment Allen P. Kaplan, MD Address patients with chronic urticaria in spite of the fact that Division of Pulmonary and Critical Care Medicine and Allergy and patients with SLE may also have hives. A number of articles Clinical Immunology, and Konishi-MUSC Institute for Inflammation have appeared to indicate that a small percentage of Research, Department of Medicine, Medical University of patients with chronic urticaria, perhaps between 5% and South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA. 10%, have circulating anti-IgE antibodies that can cross- Email: kaplana@musc.edu link IgE on the surface of basophils or mast cells, cause Current Allergy and Asthma Reports 2002, 2:263–264 them to degranulate, and lead to hive formation. More Current Science Inc. ISSN 1529-7322 Copyright © 2002 by Current Science Inc. importantly, however, were studies by Hide et al. in Malcolm Greaves’ group [1], who first demonstrated that approximately one third of patients with chronic urticaria Introduction have a circulating IgG antibody directed to the ∝ subunit of Chronic urticaria has been considered a cutaneous disease the IgE receptor. Thus, this antibody can cross-link of unknown origin which, when severe, causes significant IgE
Current Allergy and Asthma Reports – Springer Journals
Published: May 27, 2002
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