In recent years, important progress has been made in understanding the pathophysiology, and in improving the diagnosis and treatment, of chronic lymphocytic leukemia (CLL). The characteristics of the B lymphocyte clone are now better defined and disclose great heterogeneity in the mechanisms involved in the development of lymphocytic tumours: both proliferative and apoptotic abnormalities are involved, and a single or recurrent triggering feature is not recognized. Accordingly, the course of the disease is highly variable. Although treatment abstention or deferral for a long period is convenient for many patients, others who present with, or progress to, active CLL will ultimately die from the disease.
American Journal of Cancer – Springer Journals
Published: Aug 9, 2012
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