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Chitosan and collagen composite for potential application as bone substitute

Chitosan and collagen composite for potential application as bone substitute Purpose Biopolymers, such as chitosan and collagen, have excellent biocompatibility and can be used for bone remodeling. Chitosan and collagen can be crosslinked by glutaraldehyde. The aim of this study was to formulate a chitosan, collagen, and calcium phosphate-based device for potential application as bone substitutes. Methods The device was synthesized, molded, dried, and characterized. Results By FTIR, it was possible to observe a characteristic peak relating to the crosslinking of chitosan and collagen. The images of SEM and BET/BJH results showed the presence of apparent and interconnected pores. TG-DSC have shown two temperature ranges for weight loss. Mechanical tests provided an elastic modulus equal to 239.25 ± 78.37 MPa and maximum tension of 4.33 ± 0.95 MPa, which are comparable to some commercial bone substitutes and other similar synthetic devices. Conclusion The synthesized device showed interconnected pores and surficial porosity, besides thermal stability at physiological temperature, and mechanical properties comparable to spongy bones. . . . . Keywords Collagen Chitosan Calcium phosphate Bone tissue Regeneration Introduction these grafts have disadvantages, such as amount of graft har- vested from the donor site, diseases transmission, and incom- Diseases, such as osteoporosis and trauma, can cause loss or patibility, respectively (Oryan http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Biomedical Engineering Springer Journals

Chitosan and collagen composite for potential application as bone substitute

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Publisher
Springer Journals
Copyright
Copyright © 2019 by Sociedade Brasileira de Engenharia Biomedica
Subject
Engineering; Biomedical Engineering and Bioengineering; Biomaterials; Biomedical Engineering/Biotechnology
ISSN
2446-4732
eISSN
2446-4740
DOI
10.1007/s42600-019-00002-5
Publisher site
See Article on Publisher Site

Abstract

Purpose Biopolymers, such as chitosan and collagen, have excellent biocompatibility and can be used for bone remodeling. Chitosan and collagen can be crosslinked by glutaraldehyde. The aim of this study was to formulate a chitosan, collagen, and calcium phosphate-based device for potential application as bone substitutes. Methods The device was synthesized, molded, dried, and characterized. Results By FTIR, it was possible to observe a characteristic peak relating to the crosslinking of chitosan and collagen. The images of SEM and BET/BJH results showed the presence of apparent and interconnected pores. TG-DSC have shown two temperature ranges for weight loss. Mechanical tests provided an elastic modulus equal to 239.25 ± 78.37 MPa and maximum tension of 4.33 ± 0.95 MPa, which are comparable to some commercial bone substitutes and other similar synthetic devices. Conclusion The synthesized device showed interconnected pores and surficial porosity, besides thermal stability at physiological temperature, and mechanical properties comparable to spongy bones. . . . . Keywords Collagen Chitosan Calcium phosphate Bone tissue Regeneration Introduction these grafts have disadvantages, such as amount of graft har- vested from the donor site, diseases transmission, and incom- Diseases, such as osteoporosis and trauma, can cause loss or patibility, respectively (Oryan

Journal

Research on Biomedical Engineering – Springer Journals

Published: Feb 18, 2019

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