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- Publisher
- Springer Journals
- Copyright
- Copyright © 2014 by Springer Science+Business Media New York
- Subject
- Medicine & Public Health; Imaging / Radiology
- eISSN
- 2167-4825
- DOI
- 10.1007/s40134-014-0081-9
- Publisher site
- See Article on Publisher Site
Abstract
Double-strand breaks (DSB) are considered to be the most relevant X-ray-induced DNA damages. γ-H2AX immunofluorescence microscopy is a sensitive and reliable method for the quantification of distinct DSB. The detectable amount of these DNA damages correlates well with the dose received. A protective effect of different antioxidants has been postulated. This review explains the principle of the γ-H2AX technique, describes important results concerning DSB in radiologic examinations, and provides an overview on studies evaluating the effect of antioxidants on radiation-induced DNA damages with a special focus on recent studies using the γ-H2AX method.
Journal
Current Radiology Reports – Springer Journals
Published: Nov 11, 2014