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Change in cytokine profile of rats in protective antiulcer effects of glyprolines. Effects of glyprolines (PGP and N-acetyl-PGP) on expression of cytokine genes in ethanol ulcer formation

Change in cytokine profile of rats in protective antiulcer effects of glyprolines. Effects of... The effects of glyprolines (PGP and N-acetyl-PGP) on the expression of cytokine genes in the ethanol ulcer formation model have been investigated. Determination of the activity of mRNA in peripheral blood mononuclear cells has been performed using methods of reverse transcription and polymerase chain reaction. It has been shown that, in control animals, the formation of ethanol damages of gastric mucosa in some cases is accompanied by inhibition of transcription of IFN-α, IL-6, IL-12, and TNF-α and increased transcription of IFN-Γ, IL-8, IL-10. PGP reduces the injury area by 38%, which is accompanied by significantly increased gene expression of IL-1β. The peptide Ac-PGP does not change the area of ethanol ulcers but inhibits the transcription of IFN-α, TNF-α (p < 0.05), and IFN-Γ. Thus, the gastroprotective effect of PGP is probably mediated through IL-1β. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Moscow University Biological Sciences Bulletin Springer Journals

Change in cytokine profile of rats in protective antiulcer effects of glyprolines. Effects of glyprolines (PGP and N-acetyl-PGP) on expression of cytokine genes in ethanol ulcer formation

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References (23)

Publisher
Springer Journals
Copyright
Copyright © 2013 by Allerton Press, Inc.
Subject
Life Sciences; Biochemistry, general; Cell Biology; Life Sciences, general; Plant Sciences; Zoology
ISSN
0096-3925
eISSN
1934-791X
DOI
10.3103/S0096392513030085
Publisher site
See Article on Publisher Site

Abstract

The effects of glyprolines (PGP and N-acetyl-PGP) on the expression of cytokine genes in the ethanol ulcer formation model have been investigated. Determination of the activity of mRNA in peripheral blood mononuclear cells has been performed using methods of reverse transcription and polymerase chain reaction. It has been shown that, in control animals, the formation of ethanol damages of gastric mucosa in some cases is accompanied by inhibition of transcription of IFN-α, IL-6, IL-12, and TNF-α and increased transcription of IFN-Γ, IL-8, IL-10. PGP reduces the injury area by 38%, which is accompanied by significantly increased gene expression of IL-1β. The peptide Ac-PGP does not change the area of ethanol ulcers but inhibits the transcription of IFN-α, TNF-α (p < 0.05), and IFN-Γ. Thus, the gastroprotective effect of PGP is probably mediated through IL-1β.

Journal

Moscow University Biological Sciences BulletinSpringer Journals

Published: Sep 13, 2013

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