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BA Umarova, TV Lelekova, GN Kopylova, EL Koncharova, ZV Bakaeva, GE Samonina (2006)
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Estestv. Nauki
The effects of glyprolines (PGP and N-acetyl-PGP) on the expression of cytokine genes in the ethanol ulcer formation model have been investigated. Determination of the activity of mRNA in peripheral blood mononuclear cells has been performed using methods of reverse transcription and polymerase chain reaction. It has been shown that, in control animals, the formation of ethanol damages of gastric mucosa in some cases is accompanied by inhibition of transcription of IFN-α, IL-6, IL-12, and TNF-α and increased transcription of IFN-Γ, IL-8, IL-10. PGP reduces the injury area by 38%, which is accompanied by significantly increased gene expression of IL-1β. The peptide Ac-PGP does not change the area of ethanol ulcers but inhibits the transcription of IFN-α, TNF-α (p < 0.05), and IFN-Γ. Thus, the gastroprotective effect of PGP is probably mediated through IL-1β.
Moscow University Biological Sciences Bulletin – Springer Journals
Published: Sep 13, 2013
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