Access the full text.
Sign up today, get DeepDyve free for 14 days.
R. Packer, L. Sutton, T. Atkins, J. Radcliffe, G. Bunin, G. D'angio, K. Siegel, L. Schut (1989)
A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results.Journal of neurosurgery, 70 5
S. Palmer, O. Goloubeva, W. Reddick, J. Glass, A. Gajjar, L. Kun, T. Merchant, R. Mulhern (2001)
Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 19 8
D. Waber, S. Carpentieri, N. Klar, L. Silverman, M. Schwenn, C. Hurwitz, P. Mullenix, N. Tarbell, S. Sallan (2000)
Cognitive sequelae in children treated for acute lymphoblastic leukemia with dexamethasone or prednisone.Journal of pediatric hematology/oncology, 22 3
G.J. Bosl, R.J. Motzer (1997)
Testicular germ-cell cancer [published erratum appears in N Engl J Med 1997; 337 (19): 1403]N Engl J Med, 337
C. Glanzmann, W. Seelentag (1989)
Radiotherapy for tumours of the pineal region and suprasellar germinomas.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 16 1
L. Sutton, J. Radcliffe, J. Goldwein, P. Phillips, A. Janss, R. Packer, H. Zhao (1999)
Quality of life of adult survivors of germinomas treated with craniospinal irradiation.Neurosurgery, 45 6
J. Siffert, Marcia Greenleaf, Rebecca Mannis, Jeffrey Allen (1999)
Pediatric brain tumors.Pediatric annals, 26 1O
L. Constine, P. Woolf, D. Cann, G. Mick, K. McCormick, R. Raubertas, P. Rubin (1993)
Hypothalamic-Pituitary Dysfunction after Radiation for Brain TumorsThe New England Journal of Medicine, 328
H. Shirato, Y. Sawamura, M. Tada, R. Brauner, L. Adan, J. Souberbielle, N. Satoh, M. Kashiwamura, J. Murata (1998)
Adverse effect of therapy and late sequelae in survivors
Stephen Sands, Stewart Kellie, Amy Davidow, Blanca Diez, J. Villablanca, Howard Weiner, M. Pietanza, Casilda Balmaceda, Jonathan Finlay (2001)
Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: from the First International CNS Germ-Cell Tumor Study.Neuro-oncology, 3 3
J. Allen, R. Darosso, B. Donahue, A. Nirenberg (1994)
A phase II trial of preirradiation carboplatin in newly diagnosed germinoma of the central nervous systemCancer, 74
M. Benesch, H. Lackner, S. Schagerl, S. Gallistl, E. Frey, C. Urban (2001)
Tumor‐ and treatment‐related side effects after multimodal therapy of childhood intracranial germ cell tumorsActa Pædiatrica, 90
M. Ris, R. Noll (1994)
Long-term neurobehavioral outcome in pediatric brain-tumor patients: review and methodological critique.Journal of clinical and experimental neuropsychology, 16 1
Hiroki Shirato, Masamichi Nishio, Yutaka Sawamura, M. Myohjin, T. Kitahara, T. Nishioka, Yoshihide Mizutani, Hiroshi Abe, Kazuo Miyasaka (1997)
Analysis of long-term treatment of intracranial germinoma.International journal of radiation oncology, biology, physics, 37 3
K. Chik, Chi-kong Li, M. Shing, T. Leung, P. Yuen (1999)
Intracranial germ cell tumors in children with and without Down syndrome.Journal of pediatric hematology/oncology, 21 2
P. Hardenbergh, Jeffrey Golden, Amy Billet, R. Scott, R. Scott, D. Shrieve, Barbara Silver, Jay Loeffler, N. Tarbell (1997)
Intracranial germinoma: the case for lower dose radiation therapy.International journal of radiation oncology, biology, physics, 39 2
Yuta Shibamoto, M. Takahashi, M. Abe (1994)
Reduction of the radiation dose for intracranial germinoma: a prospective study.British Journal of Cancer, 70
J. Radcliffe, G. Bunin, L. Sutton, J. Goldwein, Peter Phillips∥ (1994)
Cognitive deficits in long-term survivors of childhood medulloblastoma and other noncortical tumors: Age-dependent effects of whole brain radiationInternational Journal of Developmental Neuroscience, 12
J. Ware (2003)
SF-36 health survey: Manual and interpretation guide
G. Bosl, R. Motzer (1997)
Testicular germ-cell cancer.The New England journal of medicine, 337 4
J. Buckner, P. Peethambaram, W. Smithson, R. Groover, P. Schomberg, D. Kimmel, C. Raffel, J. O'fallon, J. Neglia, E. Shaw (1999)
Phase II trial of primary chemotherapy followed by reduced-dose radiation for CNS germ cell tumors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 17 3
J. Silber, J. Radcliffe, V. Peckham, G. Perilongo, P. Kishnani, M. Fridman, J. Goldwein, A. Meadows (1992)
Whole-brain irradiation and decline in intelligence: the influence of dose and age on IQ score.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 10 9
J. Siffert, M. Greenleaf, R. Mannis (1999)
Pediatrie brain tumorsChild Adolesc Psychiatr Clin N Am, 8
D. Linstadt, W. Wara, M. Edwards, Roger Hudgins, G. Sheline (1988)
Radiotherapy of primary intracranial germinomas: the case against routine craniospinal irradiation.International journal of radiation oncology, biology, physics, 15 2
J. Varni, Tasha Burwinkle, E. Katz, K. Meeske, Paige Dickinson (2002)
The PedsQL™ in pediatric cancerCancer, 94
H. Oka, N. Kawano, Tomoko Tanaka, S. Utsuki, I. Kobayashi, H. Maezawa, K. Fujii (1998)
Long-term functional outcome of suprasellar germinomas: Usefulness and limitations of radiotherapyJournal of Neuro-Oncology, 40
M. Korkman, U. Kirk, S. Kemp (1997)
NEPSY: a developmental neuropsychological assessment
T. Nakashima, Y. Nishimura, N. Sakai, Hiromu Yamada, A. Hara (1997)
Germinoma in cerebral hemisphere associated with Down syndromeChild's Nervous System, 13
J.L. Landgraf, L. Abetz, J.E. Ware (1996)
The Child Health Questionnaire (CHQ): a user’s manual
David Cella, Amy Bonomi (1995)
Measuring quality of life: 1995 update.Oncology, 9 11 Suppl
J. Allen, G. Bosl, R. Walker (2005)
Chemotherapy trials in recurrent primary intracranial germ cell tumorsJournal of Neuro-Oncology, 3
M. Dattoli, J. Newall (1990)
Radiation therapy for intracranial germinoma: the case for limited volume treatment.International journal of radiation oncology, biology, physics, 19 2
J. Ware (1994)
SF-36 physical and mental health summary scales : a user's manual
J. Allen, J. Kim, R. Packer (1987)
Neoadjuvant chemotherapy for newly diagnosed germ-cell tumors of the central nervous system.Journal of neurosurgery, 67 1
C. Chapman, D. Waber, J. Bernstein, S. Pomeroy, B. Lavally, S. Sallan, N. Tarbell (1995)
Neurobehavioral and Neurologic Outcome in Long-Term Survivors of Posterior Fossa Brain Tumors: Role of Age and Perioperative FactorsJournal of Child Neurology, 10
M. Matsutani, K. Takakura, K. Sano (1987)
Primary intracranial germ cell tumors: pathology and treatment.Progress in experimental tumor research, 30
J.W. Varni, E.R. Katz, M. Seid (1998)
The pediatric cancer quality of life inventory-32 (PCQL-32). I: reliability and validityCancer, 82
R. Packer, J. Goldwein, H. Nicholson, L. Vezina, J. Allen, M. Ris, Karin Muraszko, L. Rorke, W. Wara, B. Cohen, J. Boyett (1999)
Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 17 7
S. Bhatia, M. Jenney, M. Bogue, T. Rockwood, J. Feusner, D. Friedman, L. Robison, R. Kane (2002)
The Minneapolis-Manchester Quality of Life instrument: reliability and validity of the Adolescent Form.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 20 24
M. Fouladi, R. Grant, S. Baruchel, H. Chan, D. Malkin, S. Weitzman, Mark Greenberg (1998)
Comparison of survival outcomes in patients with intracranial germinomas treated with radiation alone versus reduced-dose radiation and chemotherapyChild's Nervous System, 14
H. Aoyama, H. Shirato, J. Ikeda, K. Fujieda, K. Miyasaka, Y. Sawamura (2002)
Induction chemotherapy followed by low-dose involved-field radiotherapy for intracranial germ cell tumors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 20 3
J. Radcliffe, R. Packer, T. Atkins, G. Bunin, L. Schut, J. Goldwein, L. Sutton (1992)
Three‐ and four‐year cognitive outcome in children with noncortical brain tumors treated with whole‐brain radiotherapyAnnals of Neurology, 32
J. Fletcher, D. Copeland (1988)
Neurobehavioral effects of central nervous system prophylactic treatment of cancer in children.Journal of clinical and experimental neuropsychology, 10 4
D. Jenkin, Martin Berry, Helen Chan, Mark Greenberg, B. Hendrick, Harold Hoffman, Robin Humphreys, Marilyn Sonley, Sheila Weitzman (1990)
Pineal region germinomas in childhood treatment considerations.International journal of radiation oncology, biology, physics, 18 3
H. Hoffman, H. Otsubo, Hendrick Eb, R. Humphreys, J. Drake, L. Becker, M. Greenberg, D. Jenkin (1991)
Intracranial germ-cell tumors in children.Journal of neurosurgery, 74 4
Thomas Merchant, Scot Sherwood, R. Mulhern, Susan Rose, Stephen Thompson, R. Sanford, Larry Kun (2000)
CNS germinoma: disease control and long-term functional outcome for 12 children treated with craniospinal irradiation.International journal of radiation oncology, biology, physics, 46 5
J.E. Ware, M. Kosinski, J. Dewey (2000)
How to score version 2 of the SF-36 Health Survey
S. Wolden, W. Wara, D. Larson, M. Prados, M. Edwards, P. Sneed (1995)
Radiation therapy for primary intracranial germ-cell tumors.International journal of radiation oncology, biology, physics, 32 4
S. Huh, I. Kim, S. Ha, C. Park (1992)
Radiotherapy of germinomas involving the basal ganglia and thalamus.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 25 3
M. Matsutani, K. Sano, K. Takakura, T. Fujimaki, O. Nakamura, N. Funata, T. Seto (1997)
Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases.Journal of neurosurgery, 86 3
D. Delis, E. Kaplan, J. Kramer (2001)
Delis-Kaplan executive function system
C.R. Reynolds, R.W. Kamphaus (1998)
Behavior assessment system for children
A. Kiltie, H. Gattamaneni (1995)
Survival and quality of life of paediatric intracranial germ cell tumour patients treated at the Christie Hospital, 1972-1993.Medical and pediatric oncology, 25 6
R. Mulhern, Janet Hancock, D. Fairclough, L. Kun (1992)
Neuropsychological status of children treated for brain tumors: a critical review and integrative analysis.Medical and pediatric oncology, 20 3
J.W. Varni, T.M. Burwinkle, E.R. Katz (2002)
The PedsQL in pediatrie cancer: reliability and validity of the Pediatrie Quality of Life Inventory Generic Core Scales, Multidimensional Fatigue Scale, and Cancer ModuleCancer, 94
Yutaka Sawamura, Jun Ikeda, Hiroki Shirato, Mitsuhiro Tada, Hiroshi Abe (1998)
Germ cell tumours of the central nervous system: treatment consideration based on 111 cases and their long-term clinical outcomes.European journal of cancer, 34 1
P. Duffner, Michael Cohen, Mitchell Parker (1988)
Prospective intellectual testing in children with brain tumorsAnnals of Neurology, 23
G. Gioia, Peter Isquith, Guy Sc, L. Kenworthy (2000)
Behavior Rating Inventory for Executive Function, 6
T. Achenbach (2001)
Achenbach System of Empirically Based Assessment (ASEBA)
J. Varni, E. Katz, M. Seid, Daniel Quiggins, Amy Friedman-Bender (1998)
The pediatric cancer quality of life inventory‐32 (PCQL‐32)Cancer, 82
D. Bearison, R. Mulhern (1994)
Neuropsychological Late Effects
Primary central nervous system (CNS) germinoma is readily curable with relatively large volume/high dose radiotherapy but the late effects of treatment may alter neurocognitive functioning and quality of life. Prior studies have associated radiation therapy with deficits in the domains of intelligence, attention, memory, and psychomotor processing speed, with risk factors including young age at irradiation and increased irradiation volume and dosage level. Furthermore, cranial irradiation may also lead to diminished height, neuroendocrine dysfunction, and hearing loss.
American Journal of Cancer – Springer Journals
Published: Aug 10, 2012
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.