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C. Karagiannidis, M. Akdiş, P. Holopainen, N. Woolley, G. Hense, B. Rückert, Pierre-Yves Mantel, G. Menz, C. Akdis, K. Blaser, C. Schmidt‐Weber (2004)
Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma.The Journal of allergy and clinical immunology, 114 6
D. Demeo, V. Carey, H. Chapman, J. Reilly, L. Ginns, F. Speizer, S. Weiss, E. Silverman (2004)
Familial aggregation of FEF25–75 and FEF25–75/FVC in families with severe, early onset COPDThorax, 59
V. Coetzee, Stella Faerber, J. Greeff, C. Lefevre, Daniel Re, D. Perrett (2012)
African Perceptions of Female AttractivenessPLoS ONE, 7
J. Bluestone, Q. Tang (2005)
How do CD4+CD25+ regulatory T cells control autoimmunity?Current opinion in immunology, 17 6
Li Yang, Q. Ma, W. Yao, Qiao Zhang, Hua-ping Chen, Guan-song Wang, Chang-zheng Wang (2011)
Relationship between the anti-inflammatory properties of salmeterol/fluticasone and the expression of CD4+CD25+Foxp3+ regulatory T cells in COPDRespiratory Research, 12
S. Long, J. Buckner (2011)
CD4+FOXP3+ T Regulatory Cells in Human Autoimmunity: More Than a Numbers GameThe Journal of Immunology, 187
S. Zheng, Juhua Wang, Pu Wang, J. Gray, D. Horwitz (2007)
IL-2 Is Essential for TGF-β to Convert Naive CD4+CD25− Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells1The Journal of Immunology, 178
B. Barceló, J. Pons, J. Ferrer, J. Sauleda, A. Fuster, A. Agustí (2008)
Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smokingEuropean Respiratory Journal, 31
J. Plumb, L. Smyth, H. Adams, J. Vestbo, J. Vestbo, A. Bentley, S. Singh (2009)
Increased T-regulatory cells within lymphocyte follicles in moderate COPDEuropean Respiratory Journal, 34
(2012)
CD4 CD25CD127 regulatory T cells in peripheral blood are not an independent factor for chronic graft-versus-host disease after allogeneic stem cell transplantation
R. Vandivier, P. Henson, I. Douglas (2006)
Translating Basic Research into Clinical PracticeBurying the Dead: The Impact of Failed Apoptotic Cell Removal (Efferocytosis) on Chronic Inflammatory Lung DiseaseChest, 129
Trent Larson, R. Gudavalli, Dean Prater, S. Sutton (2015)
Critical analysis of common canister programs: a review of cross-functional considerations and health system economicsCurrent Medical Research and Opinion, 31
E. Pace, C. Sano, S. Grutta, M. Ferraro, G. Albeggiani, G. Liotta, S. Vincenzo, C. Uasuf, J. Bousquet, M. Gjomarkaj (2012)
Multiple In Vitro and In Vivo Regulatory Effects of Budesonide in CD4+ T Lymphocyte Subpopulations of Allergic AsthmaticsPLoS ONE, 7
Todd Davidson, R. DiPaolo, J. Andersson, E. Shevach (2007)
Cutting Edge: IL-2 Is Essential for TGF-β-Mediated Induction of Foxp3+ T Regulatory CellsThe Journal of Immunology, 178
J. Hogg (2004)
Pathophysiology of airflow limitation in chronic obstructive pulmonary diseaseThe Lancet, 364
M. Profita, G. Albano, Loredana Riccobono, C. Sano, A. Montalbano, R. Gagliardo, Giulia Anzalone, A. Bonanno, M. Pieper, M. Gjomarkaj (2014)
Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients.Immunobiology, 219 5
Nina Lane, R. Adrian Robins, J. Corne, L. Fairclough (2010)
Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells.Clinical science, 119 2
(2012)
CD 4 + CD 25 highCD 127 low regulatory T cells in peripheral blood are not an independent factor for chronic graft - versus - host disease after allogeneic stem cell transplantation
RW Vandivier, PM Henson, IS Douglas (2006)
Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung diseaseChest, 129
L. Smyth, C. Starkey, J. Vestbo, Dave Singh (2007)
CD4-regulatory cells in COPD patients.Chest, 132 1
Seung-Hyo Lee, S. Goswami, A. Grudo, Lizhen Song, V. Bandi, S. Goodnight-White, L. Green, Joan Hacken-Bitar, J. Huh, Faisal Bakaeen, H. Coxson, S. Cogswell, C. Storness-Bliss, D. Corry, F. Kheradmand (2007)
Antielastin autoimmunity in tobacco smoking–induced emphysemaNature Medicine, 13
Weihong Liu, A. Putnam, Xu-yu Zhou, G. Szot, Michael Lee, Shirley Zhu, P. Gottlieb, P. Kapranov, T. Gingeras, Barbara Groth, C. Clayberger, David Soper, S. Ziegler, J. Bluestone (2006)
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cellsThe Journal of Experimental Medicine, 203
K. Fizazi, G. Hudes, W. Berry, W. Kelly, J. Eymard, C. Logothetis, A. Maître, J. Pignon, S. Michiels (2006)
A meta-analysis of individual patient data from randomized trials assessing chemotherapy with and without estramustine in patients with castration-refractory prostate cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 24 18_suppl
M. Vargas-Rojas, A. Ramírez-Venegas, Leonardo Limón-Camacho, Leticia Ochoa, R. Hernández-Zenteno, R. Sansores (2011)
Increase of Th17 cells in peripheral blood of patients with chronic obstructive pulmonary disease.Respiratory medicine, 105 11
R. Gregg, Christopher Smith, F. Clark, D. Dunnion, N. Khan, R. Chakraverty, L. Nayak, P. Moss (2005)
The number of human peripheral blood CD4+ CD25high regulatory T cells increases with ageClinical & Experimental Immunology, 140
M. Latorre, F. Novelli, B. Vagaggini, Fulvio Braido, Alberto Papi, Alessandro Sanduzzi, P. Santus, Nicola Scichilone, P. Paggiaro (2015)
Differences in the efficacy and safety among inhaled corticosteroids (ICS)/long-acting beta2-agonists (LABA) combinations in the treatment of chronic obstructive pulmonary disease (COPD): Role of ICS.Pulmonary pharmacology & therapeutics, 30
D. Sin, D. Tashkin, Xuekui Zhang, F. Radner, U. Sjöbring, A. Thorén, P. Calverley, S. Rennard (2009)
Budesonide and the risk of pneumonia: a meta-analysis of individual patient dataThe Lancet, 374
E. Eisenstein, C. Williams (2009)
The Treg/Th17 Cell Balance: A New Paradigm for AutoimmunityPediatric Research, 65
C. Feghali-Bostwick, Aneal Gadgil, L. Otterbein, J. Pilewski, M. Stoner, E. Csizmadia, Yingze Zhang, F. Sciurba, S. Duncan (2008)
Autoantibodies in patients with chronic obstructive pulmonary disease.American journal of respiratory and critical care medicine, 177 2
S. Suissa, V. Patenaude, F. Lapi, P. Ernst (2013)
Inhaled corticosteroids in COPD and the risk of serious pneumoniaThorax, 68
W. Macnee (2005)
Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease.Proceedings of the American Thoracic Society, 2 1
J. Domagała-Kulawik, G. Hoser, M. Dąbrowska, A. Safianowska, R. Chazan (2011)
CD4+/CD25+ Cells in Systemic Inflammation in COPDScandinavian Journal of Immunology, 73
Min-Jong Kang, C. Lee, Jae‐Young Lee, C. Cruz, Zhijian Chen, R. Enelow, J. Elias (2008)
Cigarette smoke selectively enhances viral PAMP- and virus-induced pulmonary innate immune and remodeling responses in mice.The Journal of clinical investigation, 118 8
J. Raynor, Celine Lages, H. Shehata, David Hildeman, C. Chougnet (2012)
Homeostasis and function of regulatory T cells in aging.Current opinion in immunology, 24 4
L. Blais, A. Forget, S. Ramachandran (2010)
Relative effectiveness of budesonide/formoterol and fluticasone propionate/salmeterol in a 1-year, population-based, matched cohort study of patients with chronic obstructive pulmonary disease (COPD): Effect on COPD-related exacerbations, emergency department visits and hospitalizations, medicationClinical therapeutics, 32 7
C. Crim, P. Calverley, Julie Anderson, B. Celli, G. Ferguson, C. Jenkins, P. Jones, L. Willits, J. Yates, J. Vestbo (2009)
Pneumonia risk in COPD patients receiving inhaled corticosteroids alone or in combination: TORCH study resultsEuropean Respiratory Journal, 34
L. Steinman (2006)
Four easy pieces : Interconnections between tissue injury, intermediary metabolism, autoimmunity, and chronic degeneration, 3
L Steinman (2006)
State of the art. Four easy pieces: interconnections between tissue injury, intermediary metabolism, autoimmunity, and chronic degenerationProc Am Thorac Soc, 3
E. Roos-Engstrand, J. Pourazar, A. Behndig, A. Bucht, A. Blomberg (2011)
Expansion of CD4+CD25+ helper T cells without regulatory function in smoking and COPDRespiratory Research, 12
Z. Vadasz, T. Haj, A. Kessel, E. Toubi (2013)
Age-related autoimmunityBMC Medicine, 11
X. Xiong, Yang Jin, Qiong Zhou, Xiao-ju Zhang, W. Du, Wei Liu, Shi-ang Huang (2008)
[Correlation between FoxP3(+) regulatory T cells and chronic obstructive pulmonary disease].Zhonghua yi xue za zhi, 88 7
K. Geest, W. Abdulahad, Sarah Tete, P. Lorencetti, G. Horst, N. Bos, B. Kroesen, E. Brouwer, A. Boots (2014)
Aging disturbs the balance between effector and regulatory CD4+ T cellsExperimental Gerontology, 60
C. Folli, A. Chiappori, M. Pellegrini, Valentina Garelli, A. Riccio, L. Ferrari, F. Braido, G. Canonica (2012)
COPD treatment: real life and experimental effects on peripheral NK cells, their receptors expression and their IFN-γ secretion.Pulmonary pharmacology & therapeutics, 25 5
R. Tuder, Toshinori Yoshida, W. Arap, R. Pasqualini, I. Petrache (2006)
State of the art. Cellular and molecular mechanisms of alveolar destruction in emphysema: an evolutionary perspective.Proceedings of the American Thoracic Society, 3 6
D. Tan, S. Fernández, P. Price, M. French, P. Thompson, Y. Moodley (2014)
Impaired function of regulatory T-cells in patients with chronic obstructive pulmonary disease (COPD).Immunobiology, 219 12
J. Perz, Selma Gürel, S. Schonland, U. Hegenbart, A. Ho, P. Dreger (2012)
CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell TransplantationThe Scientific World Journal, 2012
L Blais, A Forget, S Ramachandran (2010)
Relative effectiveness of budesonide/formoterol and fluticasone propionate/salmeterol in a 1-year, population-based, matched cohort study of patients with chronic obstructive pulmonary disease (COPD): Effect on COPD-related exacerbations, emergency department visits and hospitalizations, medication utilization, and treatment adherenceClin Ther, 32
E. Peek, D. Richards, A. Faith, P. Lavender, Tak Lee, C. Corrigan, C. Hawrylowicz (2005)
Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists.American journal of respiratory cell and molecular biology, 33 1
C. Janson, K. Larsson, K. Lisspers, B. Ställberg, G. Stratelis, H. Goike, L. Jörgensen, G. Johansson (2013)
Pneumonia and pneumonia related mortality in patients with COPD treated with fixed combinations of inhaled corticosteroid and long acting β2 agonist: observational matched cohort study (PATHOS)The BMJ, 346
D. Parums (2023)
Editorial: Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2023 Guidelines for COPD, Including COVID-19, Climate Change, and Air PollutionMedical Science Monitor : International Medical Journal of Experimental and Clinical Research, 29
Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder characterized by poorly reversible airway obstruction and its pathogenesis remains largely misunderstood. Local changes of regulatory T-cell populations in the lungs of COPD patients have been demonstrated although data concerning their pathologic role are contrasting. The aim of our study was to evaluate the relative percentage of regulatory T-cells in the peripheral blood of current and former smoker subjects, affected or not by COPD. Furthermore, the effect of different concentrations of budesonide and formoterol, on regulatory T-cells has been investigated. + high - Methods: T regulatory lymphocytes were isolated and assessed as CD4 CD25 CD127 cells by flow cytometry and cultured for 48 hours in the absence or in the presence of budesonide and/or formoterol at different doses. + high - Results: CD4 CD25 CD127 regulatory T-cells percentage was significantly reduced in COPD patients, both + high - current and former smokers, with respect to volunteers. Furthermore, CD4 CD25 CD127 cells of COPD patients showed a not statistically significant response to drugs compared to healthy subjects. + high - Discussion: Our results evidenced a different behaviour of CD4 CD25 CD127 Treg cells in COPD patients after in vitro
World Allergy Organization Journal – Springer Journals
Published: Feb 12, 2016
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