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Case-cohort analysis with general additive-multiplicative hazard models

Case-cohort analysis with general additive-multiplicative hazard models The case-cohort design is widely used in large epidemiological studies and prevention trials for cost reduction. In such a design, covariates are assembled only for a subcohort which is a random subset of the entire cohort and any additional cases outside the subcohort. In this paper, we discuss the case-cohort analysis with a class of general additive-multiplicative hazard models which includes the commonly used Cox model and additive hazard model as special cases. Two sampling schemes for the subcohort, Bernoulli sampling with arbitrary selection probabilities and stratified simple random sampling with fixed subcohort sizes, are discussed. In each setting, an estimating function is constructed to estimate the regression parameters. The resulting estimator is shown to be consistent and asymptotically normally distributed. The limiting variance-covariance matrix can be consistently estimated by the case-cohort data. A simulation study is conducted to assess the finite sample performances of the proposed method and a real example is provided. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Mathematicae Applicatae Sinica Springer Journals

Case-cohort analysis with general additive-multiplicative hazard models

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References (21)

Publisher
Springer Journals
Copyright
Copyright © 2016 by Institute of Applied Mathematics, Academy of Mathematics and System Sciences, Chinese Academy of Sciences and Springer-Verlag Berlin Heidelberg
Subject
Mathematics; Applications of Mathematics; Math Applications in Computer Science; Theoretical, Mathematical and Computational Physics
ISSN
0168-9673
eISSN
1618-3932
DOI
10.1007/s10255-016-0605-6
Publisher site
See Article on Publisher Site

Abstract

The case-cohort design is widely used in large epidemiological studies and prevention trials for cost reduction. In such a design, covariates are assembled only for a subcohort which is a random subset of the entire cohort and any additional cases outside the subcohort. In this paper, we discuss the case-cohort analysis with a class of general additive-multiplicative hazard models which includes the commonly used Cox model and additive hazard model as special cases. Two sampling schemes for the subcohort, Bernoulli sampling with arbitrary selection probabilities and stratified simple random sampling with fixed subcohort sizes, are discussed. In each setting, an estimating function is constructed to estimate the regression parameters. The resulting estimator is shown to be consistent and asymptotically normally distributed. The limiting variance-covariance matrix can be consistently estimated by the case-cohort data. A simulation study is conducted to assess the finite sample performances of the proposed method and a real example is provided.

Journal

Acta Mathematicae Applicatae SinicaSpringer Journals

Published: Oct 1, 2016

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