Bone mass regulation and the lipoxygenase gene alox15
Abstract
186 Rhinitis Klein RF, Allard J, Avnur Z, et al. : Regulation of bone Results: Alox15 knock-out mice had lower peak mineral mass in mice by the lipoxygenase gene Alox15. Sci- densities than congenic mouse strains. 12/15-LO inhibi- ence 2004, 303:229–232. tors significantly improved bone density and strength. Rating: Of importance. Editor’s comments Introduction: The Alox15 gene encodes 12/15-lipoxygenase (12/15-LO). This enzyme converts arachidonic and linoleic 12/15-LO products...