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Biopolymers and Osmolytes — A Focus towards the Prospects of Stability and Adjuvanticity of Vaccines

Biopolymers and Osmolytes — A Focus towards the Prospects of Stability and Adjuvanticity of Vaccines ‘New-Gen Vaccines’ are grabbing the attention of scientists as they are much suitable for an immune-compromised group of individuals as well as infants. The major drawbacks of these vaccines are lower immunogenicity and instability. The need for a convenient and safe adjuvant is still under exploration. On the other hand, thermal instability leads to the inactivation of the vaccine and becomes detrimental in many cases. Thus, there is a need to incorporate new kinds of excipients into vaccine formulation to enhance the potency/immunogenicity of vaccine antigens and also act as stabilizers. A limited or single excipient in providing the required dual-activity is vital to break the stereotypical usage of the well-entrenched adverse ingredients. In the proposed review, the efficiency of naturally occurring biocompatible carbohydrate polymers and osmolytes and their ‘dual-role’ is briefed. In addition, the information on the possible mechanisms of action of carbohydrate polymers in vaccines as adjuvants and stabilizers are also discussed.[graphic not available: see fulltext] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Macromolecular Research Springer Journals

Biopolymers and Osmolytes — A Focus towards the Prospects of Stability and Adjuvanticity of Vaccines

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References (88)

Publisher
Springer Journals
Copyright
Copyright © The Polymer Society of Korea and Springer 2022
ISSN
1598-5032
eISSN
2092-7673
DOI
10.1007/s13233-022-0068-y
Publisher site
See Article on Publisher Site

Abstract

‘New-Gen Vaccines’ are grabbing the attention of scientists as they are much suitable for an immune-compromised group of individuals as well as infants. The major drawbacks of these vaccines are lower immunogenicity and instability. The need for a convenient and safe adjuvant is still under exploration. On the other hand, thermal instability leads to the inactivation of the vaccine and becomes detrimental in many cases. Thus, there is a need to incorporate new kinds of excipients into vaccine formulation to enhance the potency/immunogenicity of vaccine antigens and also act as stabilizers. A limited or single excipient in providing the required dual-activity is vital to break the stereotypical usage of the well-entrenched adverse ingredients. In the proposed review, the efficiency of naturally occurring biocompatible carbohydrate polymers and osmolytes and their ‘dual-role’ is briefed. In addition, the information on the possible mechanisms of action of carbohydrate polymers in vaccines as adjuvants and stabilizers are also discussed.[graphic not available: see fulltext]

Journal

Macromolecular ResearchSpringer Journals

Published: Sep 1, 2022

Keywords: bio-molecules; carbohydrate polymers; osmolytes; mechanism of action; new-gen vaccines; vaccine excipients

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