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Biopeptide Hyperbranched Polyether Assembled from Lactic Acid, Glutamic Acid and Polyethylene Glycol Block Chains for Drug Loading

Biopeptide Hyperbranched Polyether Assembled from Lactic Acid, Glutamic Acid and Polyethylene... A drug loading system based on biopeptide hyperbranched polyether (BHPE) had been prepared. The biopeptide hyperbranched polymer (BHP) was composed of trimellitic anhydride, lactic acid and glutamic acid chains. The BHPE was assembled by the BHP and polyethylene glycol 400 (PEG400). The effects of pH, mass ratio of BHP and PEG400 and reaction time on particle size and distribution were studied. When the pH was 7, the mass ratio of BHP and PEG400 was 1:4 and the reaction time was 1.5 h, the BHPE formed the appropriate hollow vesicle structure which the particle size was smaller and particle size distribution was better. Also the sample of BHPE exhibited the excellent performances on swelling and in vitro degradation. The salicylic acid (SA) was used as drug model and the properties of SA-loaded BHPE system were tested by LPSA, UV-Vis and TEM. The SA-loaded BHPE system possessed obvious core-skin structure, and it demonstrated good in vitro released performance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Macromolecular Research Springer Journals

Biopeptide Hyperbranched Polyether Assembled from Lactic Acid, Glutamic Acid and Polyethylene Glycol Block Chains for Drug Loading

Zhang, Linya; Xue, Wei; Gu, Limin
Macromolecular Research , Volume 27 (11) – May 11, 2019
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References (36)

Publisher
Springer Journals
Copyright
Copyright © 2019 by The Polymer Society of Korea and Springer
Subject
Chemistry; Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Physical Chemistry; Characterization and Evaluation of Materials; Nanochemistry; Nanotechnology
ISSN
1598-5032
eISSN
2092-7673
DOI
10.1007/s13233-019-7146-9
Publisher site
See Article on Publisher Site

Abstract

A drug loading system based on biopeptide hyperbranched polyether (BHPE) had been prepared. The biopeptide hyperbranched polymer (BHP) was composed of trimellitic anhydride, lactic acid and glutamic acid chains. The BHPE was assembled by the BHP and polyethylene glycol 400 (PEG400). The effects of pH, mass ratio of BHP and PEG400 and reaction time on particle size and distribution were studied. When the pH was 7, the mass ratio of BHP and PEG400 was 1:4 and the reaction time was 1.5 h, the BHPE formed the appropriate hollow vesicle structure which the particle size was smaller and particle size distribution was better. Also the sample of BHPE exhibited the excellent performances on swelling and in vitro degradation. The salicylic acid (SA) was used as drug model and the properties of SA-loaded BHPE system were tested by LPSA, UV-Vis and TEM. The SA-loaded BHPE system possessed obvious core-skin structure, and it demonstrated good in vitro released performance.

Journal

Macromolecular Research – Springer Journals

Published: May 11, 2019

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