Access the full text.
Sign up today, get DeepDyve free for 14 days.
G. Dhondalay, E. Rael, Swati Acharya, Wenming Zhang, V. Sampath, S. Galli, R. Tibshirani, S. Boyd, H. Maecker, K. Nadeau, Sandra Andorf (2018)
Food allergy and omics.The Journal of allergy and clinical immunology, 141 1
M. Gorelik, S. Narisety, A. Guerrerio, K. Chichester, C. Keet, A. Bieneman, R. Hamilton, R. Wood, J. Schroeder, P. Frischmeyer-Guerrerio (2015)
Suppression of the immunologic response to peanut during immunotherapy is often transient.The Journal of allergy and clinical immunology, 135 5
S. Sicherer, E. Morrow, H. Sampson (2000)
Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis.The Journal of allergy and clinical immunology, 105 3
M. Suárez-Fariñas, M. Suprun, Helena Chang, G. Giménez, G. Grishina, R. Getts, K. Nadeau, R. Wood, H. Sampson (2019)
Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope‐specific antibody binding profilesThe Journal of Allergy and Clinical Immunology, 143
M. Fernández-Rivas, S. Fernández, J. Nadal, M. Durana, B. García, E. González-Mancebo, S. Martín, D. Barber, P. Rico, A. Tabar (2009)
Randomized double‐blind, placebo‐controlled trial of sublingual immunotherapy with a Pru p 3 quantified peach extractAllergy, 64
G. Longo, I. Berti, A. Burks, B. Krauss, E. Barbi (2013)
IgE-mediated food allergy in childrenThe Lancet, 382
A. Thyagarajan, S. Jones, A. Calatroni, L. Pons, M. Kulis, C. Woo, M. Kamalakannan, B. Vickery, A. Scurlock, A. Burks, W. Shreffler (2012)
Evidence of pathway‐specific basophil anergy induced by peanut oral immunotherapy in peanut‐allergic childrenClinical & Experimental Allergy, 42
E. Crestani, J. Leirer, A. Motsinger-Reif, W. Phipatanakul, R. Kaddurah-Daouk, T. Chatila (2019)
Untargeted Metabolomic Profiling Identifies Disease‐Specific Pathways in Food Allergy and Asthma: 773The Journal of Allergy and Clinical Immunology, 143
P. Varshney, S. Jones, A. Scurlock, T. Perry, A. Kemper, Pamela Steele, Anne Hiegel, J. Kamilaris, S. Carlisle, Xiaohong Yue, M. Kulis, L. Pons, B. Vickery, A. Burks (2011)
A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response.The Journal of allergy and clinical immunology, 127 3
P. Eigenmann, H. Sampson (1998)
Interpreting skin prick tests in the evaluation of food allergy in childrenPediatric Allergy and Immunology, 9
E. Wambre, V. Bajzik, J. DeLong, Kimberly O’Brien, Quynh-Anh Nguyen, C. Speake, V. Gersuk, H. DeBerg, E. Whalen, Chester Ni, M. Farrington, D. Jeong, D. Robinson, P. Linsley, B. Vickery, W. Kwok (2017)
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disordersScience Translational Medicine, 9
L. Tordesillas, M. Berin, Hugh Sampson (2017)
Immunology of Food Allergy.Immunity, 47 1
S. Jones, L. Pons, Joseph Roberts, A. Scurlock, T. Perry, M. Kulis, W. Shreffler, Pamela Steele, K. Henry, M. Adair, J. Francis, S. Durham, B. Vickery, X. Zhong, A. Burks (2009)
Clinical efficacy and immune regulation with peanut oral immunotherapy.The Journal of allergy and clinical immunology, 124 2
A. Burks, S. Jones, Robert Wood, David Fleischer, S. Sicherer, R. Lindblad, Donald Stablein, A. Henning, B. Vickery, Andrew Liu, A. Scurlock, W. Shreffler, Marshall Plaut, H. Sampson (2012)
Oral Immunotherapy for Treatment of Egg Allergy in Children
H. Sampson, L. O’Mahony, A. Burks, M. Plaut, G. Lack, C. Akdis (2018)
Mechanisms of food allergy.The Journal of allergy and clinical immunology, 141 1
C. Keet, P. Frischmeyer-Guerrerio, A. Thyagarajan, J. Schroeder, R. Hamilton, S. Boden, Pamela Steele, S. Driggers, A. Burks, R. Wood (2012)
The safety and efficacy of sublingual and oral immunotherapy for milk allergy.The Journal of allergy and clinical immunology, 129 2
Julie Wang, Jing Lin, L. Bardina, M. Goldis, A. Nowak‐Wegrzyn, W. Shreffler, H. Sampson (2010)
Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy.The Journal of allergy and clinical immunology, 125 3
D. Fleischer, M. Greenhawt, G. Sussman, P. Bégin, A. Nowak‐Wegrzyn, D. Petroni, K. Beyer, T. Brown-Whitehorn, J. Hébert, J. Hourihane, D. Campbell, S. Leonard, R. Chinthrajah, J. Pongracic, S. Jones, L. Lange, H. Chong, Todd Green, Todd Green, R. Wood, A. Cheema, S. Prescott, Peter Smith, William Yang, E. Chan, A. Byrne, A. Assa'ad, J. Bird, Edwin Kim, L. Schneider, C. Davis, B. Lanser, R. Lambert, W. Shreffler (2019)
Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical TrialJAMA, 321
A. Flinterman, S. Pasmans, C. Jager, Maarten Hoekstra, C. Bruijnzeel-Koomen, Edward Knol, E. Hoffen (2010)
T cell responses to major peanut allergens in children with and without peanut allergyClinical & Experimental Allergy, 40
K. Kabashima, C. Nakashima, Y. Nonomura, A. Otsuka, Chiara Cardamone, R. Parente, G. Feo, M. Triggiani (2018)
Biomarkers for evaluation of mast cell and basophil activationImmunological Reviews, 282
B. Wright, B. Wright, M. Kulis, Kelly Orgel, A. Burks, P. Dawson, A. Henning, S. Jones, R. Wood, S. Sicherer, R. Lindblad, D. Stablein, D. Leung, B. Vickery, H. Sampson (2016)
Component‐resolved analysis of IgA, IgE, and IgG4 during egg OIT identifies markers associated with sustained unresponsivenessAllergy, 71
S. Jones, A. Burks, C. Keet, B. Vickery, A. Scurlock, R. Wood, A. Liu, S. Sicherer, A. Henning, R. Lindblad, P. Dawson, C. Berin, D. Fleischer, D. Leung, M. Plaut, H. Sampson (2016)
Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy.The Journal of allergy and clinical immunology, 137 4
Ruchi Gupta, C. Warren, Bridget Smith, Jialing Jiang, J. Blumenstock, Matthew Davis, R. Schleimer, K. Nadeau (2019)
Prevalence and Severity of Food Allergies Among US AdultsJAMA Network Open, 2
Debbi Stockhammer, C. Katelaris, T. Vanniasinkam, M. Simpson (2017)
Poster Session TPSAllergy, 72
K. Beyer, Lisa Ellman-Grunther, K. Järvinen, R. Wood, J. Hourihane, H. Sampson (2003)
Measurement of peptide-specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts.The Journal of allergy and clinical immunology, 112 1
M. Kulis, Xiaohong Yue, R. Guo, Huamei Zhang, Kelly Orgel, Ping Ye, Quefeng Li, Yutong Liu, Edwin Kim, A. Burks, B. Vickery (2018)
High‐ and low‐dose oral immunotherapy similarly suppress pro‐allergic cytokines and basophil activation in young childrenClinical & Experimental Allergy, 49
Lindsay Still, S. Jones (2014)
Sustained Unresponsiveness to Peanut in Subjects Who Have Completed Peanut Oral ImmunotherapyPediatrics, 134
W. Burks, H. Sampson, M. Plaut, G. Lack, C. Akdis (2018)
Treatment for food allergyThe Journal of Allergy and Clinical Immunology, 141
Ruchi Gupta, Elizabeth Springston, M. Warrier, Bridget Smith, R. Kumar, J. Pongracic, J. Holl (2011)
The Prevalence, Severity, and Distribution of Childhood Food Allergy in the United StatesPediatrics, 128
M. Kulis, Katie Saba, Edwin Kim, J. Bird, N. Kamilaris, B. Vickery, H. Staats, A. Burks (2012)
Increased peanut-specific IgA levels in saliva correlate with food challenge outcomes after peanut sublingual immunotherapy.The Journal of allergy and clinical immunology, 129 4
Taylor Feehley, C. Plunkett, R. Bao, Sung Hong, Elliot Culleen, P. Belda-Ferre, Evelyn Campbell, R. Aitoro, R. Nocerino, L. Paparo, J. Andrade, D. Antonopoulos, R. Canani, C. Nagler (2018)
Healthy infants harbor intestinal bacteria that protect against food allergyNature medicine, 25
Kelly Orgel, C. Burk, Johanna Smeekens, J. Suber, Lakeya Hardy, R. Guo, A. Burks, M. Kulis (2018)
Blocking antibodies induced by peanut oral and sublingual immunotherapy suppress basophil activation and are associated with sustained unresponsivenessClinical & Experimental Allergy, 49
B. Vickery, L. Pons, M. Kulis, Pamela Steele, S. Jones, A. Burks (2010)
Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 105 6
S. Jones, S. Sicherer, A. Burks, D. Leung, R. Lindblad, P. Dawson, A. Henning, M. Berin, David Chiang, B. Vickery, R. Pesek, C. Cho, F. Davidson, M. Plaut, H. Sampson, R. Wood
Food , drug , insect sting allergy , and anaphylaxis Epicutaneous immunotherapy for the treatment of peanut allergy in children and young adults
M. Rivas, O. Burton, Petra Wise, Yu-qian Zhang, S. Hobson, M. Lloret, C. Chehoud, Justin Kuczynski, T. DeSantis, J. Warrington, Embriette Hyde, J. Petrosino, G. Gerber, L. Bry, H. Oettgen, S. Mazmanian, T. Chatila (2013)
A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis.The Journal of allergy and clinical immunology, 131 1
S. Koppelman, A. Peillon, W. Agbotounou, H. Sampson, Laurent Martin (2019)
Epicutaneous immunotherapy for peanut allergy modifies IgG4 responses to major peanut allergens.The Journal of allergy and clinical immunology, 143 3
B. Rodriguez, Guénolée Prioult, Feriel Hacini-Rachinel, D. Moine, A. Bruttin, C. Ngom-Bru, Chantal Labellie, I. Nicolis, B. Berger, A. Mercenier, M. Butel, A. Waligora-Dupriet (2012)
Infant gut microbiota is protective against cow's milk allergy in mice despite immature ileal T-cell response.FEMS microbiology ecology, 79 1
D. MacGlashan (2010)
Expression of CD203c and CD63 in human basophils: relationship to differential regulation of piecemeal and anaphylactic degranulation processesClinical & Experimental Allergy, 40
B. Vickery, J. Berglund, C. Burk, J. Fine, Edwin Kim, Jung Kim, C. Keet, M. Kulis, Kelly Orgel, R. Guo, Pamela Steele, Yamini Virkud, Ping Ye, B. Wright, R. Wood, A. Burks (2016)
Food , drug , insect sting allergy , and anaphylaxis Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective
S. Narisety, P. Frischmeyer-Guerrerio, C. Keet, M. Gorelik, J. Schroeder, R. Hamilton, R. Wood (2012)
A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy.The Journal of allergy and clinical immunology, 135 5
A. Branum, Susan Lukacs (2008)
Food allergy among U.S. children: trends in prevalence and hospitalizations.NCHS data brief, 10
E. Wambre, E. James, W. Kwok (2012)
Characterization of CD4+ T cell subsets in allergy.Current opinion in immunology, 24 6
C. Burk, M. Kulis, Nicole Leung, Edwin Kim, A. Burks, B. Vickery (2016)
Utility of component analyses in subjects undergoing sublingual immunotherapy for peanut allergyClinical & Experimental Allergy, 46
R. Hamilton (2010)
Clinical laboratory assessment of immediate-type hypersensitivity.The Journal of allergy and clinical immunology, 125 2 Suppl 2
K. Anagnostou, Sabita Islam, Y. King, Loraine Foley, L. Pasea, S. Bond, C. Palmer, J. Deighton, P. Ewan, A. Clark (2014)
Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trialLancet (London, England), 383
H. Bühring, Martina Seiffert, Christina Giesert, A. Marxer, Lothar Kanz, Peter Valent, Kimihiko Sano (2001)
The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3.Blood, 97 10
T. Dang, K. Allen, David Martino, J. Koplin, P. Licciardi, M. Tang (2016)
Food‐allergic infants have impaired regulatory T‐cell responses following in vivo allergen exposurePediatric Allergy and Immunology, 27
Edward Knol, F. Mul, Hans Jansen, Jero Calafat, Dirk Roos (1991)
Monitoring human basophil activation via CD63 monoclonal antibody 435.The Journal of allergy and clinical immunology, 88 3 Pt 1
Aleena Syed, Marco Garcia, S. Lyu, Robert Bucayu, Arunima Kohli, S. Ishida, J. Berglund, M. Tsai, H. Maecker, G. O’Riordan, S. Galli, K. Nadeau (2014)
Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).The Journal of allergy and clinical immunology, 133 2
R. Ayuso, S. Sánchez-García, M. Pascal, Jing Lin, G. Grishina, Zhi-qin Fu, M. Ibáñez, J. Sastre, H. Sampson (2012)
Is epitope recognition of shrimp allergens useful to predict clinical reactivity?Clinical & Experimental Allergy, 42
Stephanie Leonard, S. Sicherer (2008)
A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy.The Journal of allergy and clinical immunology, 122 6
B. Vickery, A. Scurlock, M. Kulis, Pamela Steele, J. Kamilaris, J. Berglund, C. Burk, Anne Hiegel, S. Carlisle, L. Christie, T. Perry, R. Pesek, S. Sheikh, Yamini Virkud, P. Smith, M. Shamji, Stephen Durham, S. Jones, A. Burks (2014)
Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy.The Journal of allergy and clinical immunology, 133 2
E. Crestani, Hani Harb, L. Charbonnier, J. Leirer, A. Motsinger-Reif, R. Rachid, W. Phipatanakul, R. Kaddurah-Daouk, T. Chatila (2019)
Untargeted Metabolomic Profiling Identifies Disease-specific Signatures in Food Allergy and Asthma.The Journal of allergy and clinical immunology
Ruchi Gupta, Claudia Lau, R. Hamilton, Aaron Donnell, Kelly Newhall (2014)
Predicting outcomes of oral food challenges by using the allergen-specific IgE-total IgE ratio.The journal of allergy and clinical immunology. In practice, 2 3
Alexandra Santos, Natália Couto‐Francisco, N. Becares, M. Kwok, H. Bahnson, G. Lack (2018)
A novel human mast cell activation test for peanut allergyThe Journal of Allergy and Clinical Immunology, 142
Joshua Kong, Kenneth Chalcraft, Talveer Mandur, R. Jiménez‐Saiz, T. Walker, S. Goncharova, Melissa Gordon, L. Naji, Kristin Flader, M. Larché, D. Chu, S. Waserman, B. McCarry, M. Jordana (2015)
Comprehensive metabolomics identifies the alarmin uric acid as a critical signal for the induction of peanut allergyAllergy, 70
S. Bock, H. Sampson, F. Atkins, R. Zeiger, S. Lehrer, Martin Sachs, R. Bush, Dean Metcafe (1988)
Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual.The Journal of allergy and clinical immunology, 82 6
Edwin Kim, J. Bird, M. Kulis, S. Laubach, L. Pons, W. Shreffler, Pamela Steele, J. Kamilaris, B. Vickery, A. Burks (2011)
Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization.The Journal of allergy and clinical immunology, 127 3
S. Patil, Johanna Steinbrecher, A. Calatroni, Neal Smith, A. Ma, B. Ruiter, Yamini Virkud, Michael Schneider, W. Shreffler (2019)
Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy.The Journal of allergy and clinical immunology
Edwin Kim, Luanna Yang, Ping Ye, R. Guo, Quefeng Li, M. Kulis, A. Burks (2019)
Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization.The Journal of allergy and clinical immunology
J. Wisniewski, S. Commins, R. Agrawal, K. Hulse, M. Yu, J. Cronin, P. Heymann, A. Pomés, T. Platts-Mills, L. Workman, J. Woodfolk (2015)
Analysis of cytokine production by peanut‐reactive T cells identifies residual Th2 effectors in highly allergic children who received peanut oral immunotherapyClinical & Experimental Allergy, 45
Alexandra Santos, L. James, H. Bahnson, M. Shamji, Natália Couto‐Francisco, Sabita Islam, S. Houghton, A. Clark, A. Stephens, V. Turcanu, S. Durham, H. Gould, G. Lack (2015)
IgG4 inhibits peanut-induced basophil and mast cell activation in peanut-tolerant children sensitized to peanut major allergensThe Journal of Allergy and Clinical Immunology, 135
T. Dang, R. Peters, J. Koplin, S. Dharmage, L. Gurrin, A. Ponsonby, D. Martino, M. Neeland, M. Tang, K. Allen (2018)
Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNutsAllergy, 74
R. Peters, S. Dharmage, L. Gurrin, J. Koplin, A. Ponsonby, A. Lowe, M. Tang, D. Tey, M. Robinson, D. Hill, Helen Czech, L. Thiele, N. Osborne, K. Allen (2014)
The natural history and clinical predictors of egg allergy in the first 2 years of life: a prospective, population-based cohort study.The Journal of allergy and clinical immunology, 133 2
M. Berin, W. Shreffler (2016)
Mechanisms Underlying Induction of Tolerance to Foods.Immunology and allergy clinics of North America, 36 1
David Fleischer, A. Burks, B. Vickery, A. Scurlock, Robert Wood, S. Jones, S. Sicherer, Andrew Liu, Donald Stablein, A. Henning, Lloyd Mayer, R. Lindblad, M. Plaut, H. Sampson (2012)
Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multicenter trial.The Journal of allergy and clinical immunology, 131 1
E. Wambre, J. DeLong, E. James, R. LaFond, D. Robinson, W. Kwok (2012)
Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy.The Journal of allergy and clinical immunology, 129 2
D. Hill, R. Heine, C. Hosking (2004)
The diagnostic value of skin prick testing in children with food allergyPediatric Allergy and Immunology, 15
M. Shamji, J. Layhadi, G. Scadding, D. Cheung, M. Calderón, L. Turka, D. Phippard, S. Durham (2015)
Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response.The Journal of allergy and clinical immunology, 135 4
C. Watson, C. Watson, A. Cohain, R. Griffin, Yoojin Chun, Alexander Grishin, H. Hacyznska, G. Hoffman, N. Beckmann, H. Shah, P. Dawson, A. Henning, R. Wood, A. Burks, S. Jones, D. Leung, S. Sicherer, H. Sampson, A. Sharp, E. Schadt, S. Bunyavanich (2017)
Integrative transcriptomic analysis reveals key drivers of acute peanut allergic reactionsNature Communications, 8
T. Dang, R. Peters, K. Allen (2016)
Debates in allergy medicine: baked egg and milk do not accelerate tolerance to egg and milkThe World Allergy Organization Journal, 9
S. Sicherer, Robert Wood, B. Vickery, S. Jones, Andrew Liu, David Fleischer, P. Dawson, L. Mayer, A. Burks, Alexander Grishin, D. Stablein, H. Sampson (2013)
The natural history of egg allergy in an observational cohort.The Journal of allergy and clinical immunology, 133 2
R. Sporik, David Hill, C. Hosking (2000)
Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in childrenClinical & Experimental Allergy, 30
B. Vickery, Jing Lin, M. Kulis, Zhi-qin Fu, Pamela Steele, S. Jones, A. Scurlock, G. Giménez, L. Bardina, H. Sampson, A. Burks (2013)
Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens.The Journal of allergy and clinical immunology, 131 1
O. Burton, S. Logsdon, Joseph Zhou, J. Medina-Tamayo, A. Abdel-Gadir, M. Rivas, K. Koleoglou, T. Chatila, L. Schneider, R. Rachid, D. Umetsu, H. Oettgen (2014)
Oral immunotherapy induces IgG antibodies that act through FcγRIIb to suppress IgE-mediated hypersensitivity.The Journal of allergy and clinical immunology, 134 6
M. Shamji, C. Ljørring, J. Francis, M. Calderón, M. Larché, I. Kimber, A. Frew, H. Ipsen, K. Lund, P. Würtzen, S. Durham (2012)
Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapyAllergy, 67
N. Avery, R. King, S. Knight, J. Hourihane (2003)
Quality of life in children with peanut allergyThe Journal of Allergy and Clinical Immunology, 111
F. Hennersdorf, S. Florian, Andreas Jakob, Katharina Baumgärtner, K. Sonneck, A. Nordheim, T. Biedermann, P. Valent, H. Bühring (2005)
Identification of CD13, CD107a, and CD164 as novel basophil-activation markers and dissection of two response patterns in time kinetics of IgE-dependent upregulationCell Research, 15
Lubna Kouser, J. Kappen, Ross Walton, M. Shamji (2017)
Update on Biomarkers to Monitor Clinical Efficacy Response During and Post Treatment in Allergen ImmunotherapyCurrent Treatment Options in Allergy, 4
Bradley Chipps (2019)
AR101 Oral Immunotherapy for Peanut AllergyPediatrics, 144
J. Skripak, S. Nash, N. Brereton, Hannah Rowley, S. Oh, R. Hamilton, E. Matsui, A. Burks, R. Wood (2008)
A Randomized, Double-Blind, Placebo-Controlled (DBPC) Study of Milk Oral Immunotherapy (MOIT) for Cow's Milk Allergy (CMA)The Journal of Allergy and Clinical Immunology, 121
Sarita Patil, A. Ogunniyi, A. Calatroni, V. Tadigotla, B. Ruiter, A. Ma, J. Moon, J. Love, G. Shreffler (2015)
Food , drug , insect sting allergy , and anaphylaxis Peanut oral immunotherapy transiently expands circulating Ara h 2 – specific B cells with a homologous repertoire in unrelated subjects
Purpose of Review Investigational allergen immunotherapies (AITs) including oral immunotherapy (OIT), sublingual immuno- therapy (SLIT), and epicutaneous immunotherapy (EPIT) have proven to increase allergen thresholds required to elicit an allergic reaction in a majority of subjects. However, these studies lack consistent biomarkers to predict therapy outcomes. Here, we will review biomarkers that are currently being investigated for AIT. Recent Findings The mechanisms underlying the therapeutic benefit of AIT involve various cell types, including mast cells, basophils, T cells, and B cells. Skin prick and basophil activation tests assess effector cell sensitivity to allergen and are decreased in subjects on AIT. Allergen-specific IgE increases initially and decreases with continued therapy, while allergen-specific IgG and IgA increase throughout therapy. Allergen-induced regulatory T cells (Tregs) increase throughout therapy and were found to be associated with sustained unresponsiveness after OIT. Subjects on OIT and SLIT have decreased Th2 cytokine production during therapy. Summary Although trends have been reported, a common limitation of these biomarkers is that none are able to reproducibly predict prognosis during AIT. Further studies are needed to expand the currently available biomarker repertoire to provide personalized approaches to AIT. . . . . . . Keywords Food allergy Allergen Immunotherapy
Current Allergy and Asthma Reports – Springer Journals
Published: Dec 4, 2019
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.